TET1 mitigates prenatal fluoride-induced cognition impairment by modulating Bcl2 DNA hydroxymethylation level

TET1 mitigates prenatal fluoride-induced cognition impairment by modulating Bcl2 DNA hydroxymethylation level

Abstract Fluoride exposure during pregnancy commonly compromises fetal neurodevelopment and largely results in a broad spectrum of cognitive deficiencies in the adult offspring. However, the precise mechanisms underlying these effects remain to be fully elucidated. Herein, we investigate the impacts...

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Bibliographic Details
Main Authors: Yongle Cai, Xingdong Zeng, Mengyan Wu, Haonan Chen, Miao Sun, Hao Yang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Medicine
Subjects:
Fluoride
Cognition deficits
Neuron apoptosis
TET1
Bcl2
Hydroxymethylation
Online Access:https://doi.org/10.1186/s10020-025-01174-w
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