Assessing the topical application efficiency of two biological agents in managing chemotherapy-induced oral mucositis in children: A randomized clinical trial
Background: oral mucositis is one of the most annoying complications of chemotherapy. This randomized clinical trial aimed to assess the efficiency of Aloe Vera and Olive Oil in managing chemotherapy-induced oral mucositis. Methods: 36 children between 6 and 9 years and suffering from grade 3 or 4 o...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426821000452 |
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| author | Muaaz Alkhouli Mohannad Laflouf John C. Comisi |
| author_facet | Muaaz Alkhouli Mohannad Laflouf John C. Comisi |
| author_sort | Muaaz Alkhouli |
| collection | DOAJ |
| description | Background: oral mucositis is one of the most annoying complications of chemotherapy. This randomized clinical trial aimed to assess the efficiency of Aloe Vera and Olive Oil in managing chemotherapy-induced oral mucositis. Methods: 36 children between 6 and 9 years and suffering from grade 3 or 4 oral mucositis, according to the World Health Organization (W.H.O.) scale, were enrolled in this clinical trial. Participants were separated into three groups to treat their mucositis using Aloe Vera, Olive Oil, or sodium bicarbonate. Nurses administrated the agents four times daily with sponge sticks. Two blinded investigators examined the oral mucosa after ten days. Results: Both Aloe Vera and Olive Oil significant differences in the management of chemotherapy-induced oral mucositis compared to sodium bicarbonate treatments. Conclusions: Olive Oil is effective in managing CIOM. |
| format | Article |
| id | doaj-art-e24a8d5149e84defa4b26f2de6ffeb0c |
| institution | OA Journals |
| issn | 2212-4268 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-e24a8d5149e84defa4b26f2de6ffeb0c2025-08-20T02:01:56ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682021-07-0111337337810.1016/j.jobcr.2021.04.001Assessing the topical application efficiency of two biological agents in managing chemotherapy-induced oral mucositis in children: A randomized clinical trialMuaaz Alkhouli0Mohannad Laflouf1John C. Comisi2Department of Pediatric Dentistry, Faculty of Dentistry, Damascus University, PO Box 30621, Damascus, SyriaDepartment of Pediatric Dentistry, Faculty of Dentistry, Damascus University, PO Box 30621, Damascus, SyriaDepartment of Oral Rehabilitation, Medical University of South Carolina, James B. Edwards College of Dental Medicine, 173 Ashley Ave, BSB 548, MSC 507, Charleston, SC, 29425, USA; Corresponding author.Background: oral mucositis is one of the most annoying complications of chemotherapy. This randomized clinical trial aimed to assess the efficiency of Aloe Vera and Olive Oil in managing chemotherapy-induced oral mucositis. Methods: 36 children between 6 and 9 years and suffering from grade 3 or 4 oral mucositis, according to the World Health Organization (W.H.O.) scale, were enrolled in this clinical trial. Participants were separated into three groups to treat their mucositis using Aloe Vera, Olive Oil, or sodium bicarbonate. Nurses administrated the agents four times daily with sponge sticks. Two blinded investigators examined the oral mucosa after ten days. Results: Both Aloe Vera and Olive Oil significant differences in the management of chemotherapy-induced oral mucositis compared to sodium bicarbonate treatments. Conclusions: Olive Oil is effective in managing CIOM.http://www.sciencedirect.com/science/article/pii/S2212426821000452Aloe veraLeukemiaOlive oilOral mucositis |
| spellingShingle | Muaaz Alkhouli Mohannad Laflouf John C. Comisi Assessing the topical application efficiency of two biological agents in managing chemotherapy-induced oral mucositis in children: A randomized clinical trial Journal of Oral Biology and Craniofacial Research Aloe vera Leukemia Olive oil Oral mucositis |
| title | Assessing the topical application efficiency of two biological agents in managing chemotherapy-induced oral mucositis in children: A randomized clinical trial |
| title_full | Assessing the topical application efficiency of two biological agents in managing chemotherapy-induced oral mucositis in children: A randomized clinical trial |
| title_fullStr | Assessing the topical application efficiency of two biological agents in managing chemotherapy-induced oral mucositis in children: A randomized clinical trial |
| title_full_unstemmed | Assessing the topical application efficiency of two biological agents in managing chemotherapy-induced oral mucositis in children: A randomized clinical trial |
| title_short | Assessing the topical application efficiency of two biological agents in managing chemotherapy-induced oral mucositis in children: A randomized clinical trial |
| title_sort | assessing the topical application efficiency of two biological agents in managing chemotherapy induced oral mucositis in children a randomized clinical trial |
| topic | Aloe vera Leukemia Olive oil Oral mucositis |
| url | http://www.sciencedirect.com/science/article/pii/S2212426821000452 |
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