Prognostic value of peripheral blood neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with gastric cancer
<b>Objective</b> To determine the predictive value of peripheral blood neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) in the prognosis of patients with gastric cancer. <b>Methods</b> A retrospective analysis was conducted on the medical reco...
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The Editorial Department of Chinese Journal of Clinical Research
2025-01-01
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| Series: | Zhongguo linchuang yanjiu |
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| author | ZHANG Le, LI Wei, HUANG Zeping, WANG Wenjie, CHEN Xiao |
| author_facet | ZHANG Le, LI Wei, HUANG Zeping, WANG Wenjie, CHEN Xiao |
| author_sort | ZHANG Le, LI Wei, HUANG Zeping, WANG Wenjie, CHEN Xiao |
| collection | DOAJ |
| description | <b>Objective</b> To determine the predictive value of peripheral blood neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) in the prognosis of patients with gastric cancer.
<b>Methods</b> A retrospective analysis was conducted on the medical records of 272 gastric cancer patients who met the criteria and were treated at the Second Hospital of Lanzhou University from January 1, 2016, to December 31, 2017. The optimal diagnostic cut-off values for NLR and PLR were determined using X-tile software, according to which patients were divided into high and low NLR groups, high and low PLR groups, respectively, and the clinical data were compared and analyzed. The Cox proportional-hazards model was used to evaluate risk factors for overall survival (OS) and progression-free survival (PFS). Kaplan-Meier method was used to conduct survival analysis, while log-rank test was used to evaluated the differences.
<b>Results</b> The optimal diagnostic cutoff values for NLR and PLR were found to be 2.01 and 121.91, respectively. Based on these cutoff values, patients were classified into a low NLR group (≤2.01,n= 120) and a high NLR group (＞2.01,n= 152), as well as a low PLR group (≤121.91,n= 115) and a high PLR group (＞121.91,n= 157). The low NLR group showed statistically significant differences in body mass index (BMI), tumor stage, white blood cell count (WBC), lymphocyte count (LYM), neutrophil count (NE), and carcinoembryonic antigen (CEA) compared to the high NLR group (P ＜0.05). The low PLR group exhibited significant differences in gender, maximum tumor diameter, tumor stage, hemoglobin (Hb), red blood cell count (RBC), platelet count (PLT), LYM, NE, and carbohydrate antigen 125 (CA125) compared to the high PLR group (P ＜0.05). Both univariate and multivariate Cox analyses indicated that high NLR and high PLR were risk factors affecting OS and PFS in gastric cancer patients (P ＜0.05). Kaplan-Meier survival analysis demonstrated that the high NLR group had lower OS (68 months vs 71 months,HR= 3.163， 95% CI：1.971-5.075， P ＜0.01) and PFS (67 months vs69.5 months,HR= 3.078， 95% CI：1.917-4.941，P ＜0.01)compared to the low NLR group, and similarly, the high PLR group had lower OS (67 months vs74 months,HR= 2.707，95% CI：1.685-4.350 ，P ＜0.01) and PFS (65 months vs73 months,HR= 2.718， 95% CI：1.691-4.367，P ＜0.01) compared to the low PLR group.
<b>Conclusion</b> High NLR (＞2.01) and high PLR (＞121.91) indicate poor prognosis in gastric cancer patients and can serve as prognostic indicators for gastric cancer. |
| format | Article |
| id | doaj-art-e24a09257d9240e9bdfd2338f953108b |
| institution | DOAJ |
| issn | 1674-8182 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | The Editorial Department of Chinese Journal of Clinical Research |
| record_format | Article |
| series | Zhongguo linchuang yanjiu |
| spelling | doaj-art-e24a09257d9240e9bdfd2338f953108b2025-08-20T03:11:24ZzhoThe Editorial Department of Chinese Journal of Clinical ResearchZhongguo linchuang yanjiu1674-81822025-01-013815761,6610.13429/j.cnki.cjcr.2025.01.012Prognostic value of peripheral blood neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with gastric cancerZHANG Le, LI Wei, HUANG Zeping, WANG Wenjie, CHEN Xiao0Department of General Surgery, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730000, China<b>Objective</b> To determine the predictive value of peripheral blood neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) in the prognosis of patients with gastric cancer. <b>Methods</b> A retrospective analysis was conducted on the medical records of 272 gastric cancer patients who met the criteria and were treated at the Second Hospital of Lanzhou University from January 1, 2016, to December 31, 2017. The optimal diagnostic cut-off values for NLR and PLR were determined using X-tile software, according to which patients were divided into high and low NLR groups, high and low PLR groups, respectively, and the clinical data were compared and analyzed. The Cox proportional-hazards model was used to evaluate risk factors for overall survival (OS) and progression-free survival (PFS). Kaplan-Meier method was used to conduct survival analysis, while log-rank test was used to evaluated the differences. <b>Results</b> The optimal diagnostic cutoff values for NLR and PLR were found to be 2.01 and 121.91, respectively. Based on these cutoff values, patients were classified into a low NLR group (≤2.01,n= 120) and a high NLR group (＞2.01,n= 152), as well as a low PLR group (≤121.91,n= 115) and a high PLR group (＞121.91,n= 157). The low NLR group showed statistically significant differences in body mass index (BMI), tumor stage, white blood cell count (WBC), lymphocyte count (LYM), neutrophil count (NE), and carcinoembryonic antigen (CEA) compared to the high NLR group (P ＜0.05). The low PLR group exhibited significant differences in gender, maximum tumor diameter, tumor stage, hemoglobin (Hb), red blood cell count (RBC), platelet count (PLT), LYM, NE, and carbohydrate antigen 125 (CA125) compared to the high PLR group (P ＜0.05). Both univariate and multivariate Cox analyses indicated that high NLR and high PLR were risk factors affecting OS and PFS in gastric cancer patients (P ＜0.05). Kaplan-Meier survival analysis demonstrated that the high NLR group had lower OS (68 months vs 71 months,HR= 3.163， 95% CI：1.971-5.075， P ＜0.01) and PFS (67 months vs69.5 months,HR= 3.078， 95% CI：1.917-4.941，P ＜0.01)compared to the low NLR group, and similarly, the high PLR group had lower OS (67 months vs74 months,HR= 2.707，95% CI：1.685-4.350 ，P ＜0.01) and PFS (65 months vs73 months,HR= 2.718， 95% CI：1.691-4.367，P ＜0.01) compared to the low PLR group. <b>Conclusion</b> High NLR (＞2.01) and high PLR (＞121.91) indicate poor prognosis in gastric cancer patients and can serve as prognostic indicators for gastric cancer.http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20250112&year_id=2025&quarter_id=1&falg=1gastric cancerprognosisneutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratiooverall survivalprogression-free survival |
| spellingShingle | ZHANG Le, LI Wei, HUANG Zeping, WANG Wenjie, CHEN Xiao Prognostic value of peripheral blood neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with gastric cancer Zhongguo linchuang yanjiu gastric cancer prognosis neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio overall survival progression-free survival |
| title | Prognostic value of peripheral blood neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with gastric cancer |
| title_full | Prognostic value of peripheral blood neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with gastric cancer |
| title_fullStr | Prognostic value of peripheral blood neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with gastric cancer |
| title_full_unstemmed | Prognostic value of peripheral blood neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with gastric cancer |
| title_short | Prognostic value of peripheral blood neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with gastric cancer |
| title_sort | prognostic value of peripheral blood neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with gastric cancer |
| topic | gastric cancer prognosis neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio overall survival progression-free survival |
| url | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20250112&year_id=2025&quarter_id=1&falg=1 |
| work_keys_str_mv | AT zhangleliweihuangzepingwangwenjiechenxiao prognosticvalueofperipheralbloodneutrophiltolymphocyteratioandplatelettolymphocyteratioinpatientswithgastriccancer |