Adipose Tissue-Derived Therapies for Osteoarthritis: Multifaceted Mechanisms and Clinical Prospects
Osteoarthritis (OA) is a degenerative joint disease that significantly impacts quality of life and poses a growing economic burden. Adipose tissue-derived therapies, including both cell-based and cell-free products, have shown promising potential in promoting cartilage repair, modulating inflammatio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/9/669 |
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| _version_ | 1850137655674667008 |
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| author | Hanwen Zhang Oliver Felthaus Lukas Prantl |
| author_facet | Hanwen Zhang Oliver Felthaus Lukas Prantl |
| author_sort | Hanwen Zhang |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a degenerative joint disease that significantly impacts quality of life and poses a growing economic burden. Adipose tissue-derived therapies, including both cell-based and cell-free products, have shown promising potential in promoting cartilage repair, modulating inflammation, and improving joint function. Recent studies and clinical trials have demonstrated their regenerative effects, highlighting their feasibility as a novel treatment approach for OA. This review summarises the therapeutic mechanisms and latest advancements in adipose tissue-derived therapies, providing insights into their clinical applications and future prospects. |
| format | Article |
| id | doaj-art-e2451098d2984694a1e24ac7af84cac8 |
| institution | OA Journals |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-e2451098d2984694a1e24ac7af84cac82025-08-20T02:30:46ZengMDPI AGCells2073-44092025-05-0114966910.3390/cells14090669Adipose Tissue-Derived Therapies for Osteoarthritis: Multifaceted Mechanisms and Clinical ProspectsHanwen Zhang0Oliver Felthaus1Lukas Prantl2Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053 Regensburg, GermanyDepartment of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053 Regensburg, GermanyDepartment of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053 Regensburg, GermanyOsteoarthritis (OA) is a degenerative joint disease that significantly impacts quality of life and poses a growing economic burden. Adipose tissue-derived therapies, including both cell-based and cell-free products, have shown promising potential in promoting cartilage repair, modulating inflammation, and improving joint function. Recent studies and clinical trials have demonstrated their regenerative effects, highlighting their feasibility as a novel treatment approach for OA. This review summarises the therapeutic mechanisms and latest advancements in adipose tissue-derived therapies, providing insights into their clinical applications and future prospects.https://www.mdpi.com/2073-4409/14/9/669adipose tissueosteoarthritisclinical therapy |
| spellingShingle | Hanwen Zhang Oliver Felthaus Lukas Prantl Adipose Tissue-Derived Therapies for Osteoarthritis: Multifaceted Mechanisms and Clinical Prospects Cells adipose tissue osteoarthritis clinical therapy |
| title | Adipose Tissue-Derived Therapies for Osteoarthritis: Multifaceted Mechanisms and Clinical Prospects |
| title_full | Adipose Tissue-Derived Therapies for Osteoarthritis: Multifaceted Mechanisms and Clinical Prospects |
| title_fullStr | Adipose Tissue-Derived Therapies for Osteoarthritis: Multifaceted Mechanisms and Clinical Prospects |
| title_full_unstemmed | Adipose Tissue-Derived Therapies for Osteoarthritis: Multifaceted Mechanisms and Clinical Prospects |
| title_short | Adipose Tissue-Derived Therapies for Osteoarthritis: Multifaceted Mechanisms and Clinical Prospects |
| title_sort | adipose tissue derived therapies for osteoarthritis multifaceted mechanisms and clinical prospects |
| topic | adipose tissue osteoarthritis clinical therapy |
| url | https://www.mdpi.com/2073-4409/14/9/669 |
| work_keys_str_mv | AT hanwenzhang adiposetissuederivedtherapiesforosteoarthritismultifacetedmechanismsandclinicalprospects AT oliverfelthaus adiposetissuederivedtherapiesforosteoarthritismultifacetedmechanismsandclinicalprospects AT lukasprantl adiposetissuederivedtherapiesforosteoarthritismultifacetedmechanismsandclinicalprospects |