Non-perinatal hypoxic ischemic encephalopathy – Long term outcome and clinico-radiological correlation
Objective: To study the long-term outcome of non-perinatal Hypoxic Ischemic Encephalopathy (HIE) and to co-relate clinical outcomes with neuroimaging findings. Materials and Methods: Retrospective chart review and telephonic follow up study.Family members of 72 patients, out of 101 screened patients...
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Elsevier
2025-06-01
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| Series: | Brain Disorders |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266645932500037X |
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| author | Saraswathi Ramanathan Prince Thakkar Harshad Vanjare Raji Thomas George Tharion Bijesh Yadav |
| author_facet | Saraswathi Ramanathan Prince Thakkar Harshad Vanjare Raji Thomas George Tharion Bijesh Yadav |
| author_sort | Saraswathi Ramanathan |
| collection | DOAJ |
| description | Objective: To study the long-term outcome of non-perinatal Hypoxic Ischemic Encephalopathy (HIE) and to co-relate clinical outcomes with neuroimaging findings. Materials and Methods: Retrospective chart review and telephonic follow up study.Family members of 72 patients, out of 101 screened patients (admitted to an inpatient rehabilitation facility with diagnosis of “HIE” within 6 months of hypoxic insult) were contactable and current telephonic modified Rankin Scale (mRS) was documented. mRS of 0–3 was considered as favorable clinical outcome and mRS of 4–6 as poor outcome. Neuroimaging (CT and MRI) were reviewed by a neuro-radiologist. Results: The mean (SD) age was 34.06 (18.33) years. One year survival rate was 84.7 % (61/72 patients), with severe disability (mRS 5) in 78.6 % (n = 48) of survivors. At follow up, 60 patients (83.3 %) had poor outcome (mRS 6, 38.9 %, n = 28; mRS 5, 31.9 %, n = 23; mRS 4, 12.5 %, n = 9) and 12 patients (16.7 %) had favorable clinical outcome (mRS 2 and 3). Patients with favorable outcomes had normal imaging or subcortical involvement without diffusion restriction. Diffuse cortical and deep grey involvement, diffuse cortical white matter involvement, cerebellar involvement and brain stem involvement had worse prognosis. Conclusion: HIE has an overall poor outcome in 83.3 % of the patients. Focal findings on MRI may have a slightly better prognosis than diffuse findings. |
| format | Article |
| id | doaj-art-e243c3dd606d42739246f2fd9124f26f |
| institution | Kabale University |
| issn | 2666-4593 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Disorders |
| spelling | doaj-art-e243c3dd606d42739246f2fd9124f26f2025-08-20T03:26:20ZengElsevierBrain Disorders2666-45932025-06-011810021710.1016/j.dscb.2025.100217Non-perinatal hypoxic ischemic encephalopathy – Long term outcome and clinico-radiological correlationSaraswathi Ramanathan0Prince Thakkar1Harshad Vanjare2Raji Thomas3George Tharion4Bijesh Yadav5Department of PM&R, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of PM&R, Christian Medical College, Vellore, Tamil Nadu, India; Corresponding author: Department of PM&R, Christian Medical College, Vellore, Tamil Nadu, India,.Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of PM&R, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of PM&R, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, IndiaObjective: To study the long-term outcome of non-perinatal Hypoxic Ischemic Encephalopathy (HIE) and to co-relate clinical outcomes with neuroimaging findings. Materials and Methods: Retrospective chart review and telephonic follow up study.Family members of 72 patients, out of 101 screened patients (admitted to an inpatient rehabilitation facility with diagnosis of “HIE” within 6 months of hypoxic insult) were contactable and current telephonic modified Rankin Scale (mRS) was documented. mRS of 0–3 was considered as favorable clinical outcome and mRS of 4–6 as poor outcome. Neuroimaging (CT and MRI) were reviewed by a neuro-radiologist. Results: The mean (SD) age was 34.06 (18.33) years. One year survival rate was 84.7 % (61/72 patients), with severe disability (mRS 5) in 78.6 % (n = 48) of survivors. At follow up, 60 patients (83.3 %) had poor outcome (mRS 6, 38.9 %, n = 28; mRS 5, 31.9 %, n = 23; mRS 4, 12.5 %, n = 9) and 12 patients (16.7 %) had favorable clinical outcome (mRS 2 and 3). Patients with favorable outcomes had normal imaging or subcortical involvement without diffusion restriction. Diffuse cortical and deep grey involvement, diffuse cortical white matter involvement, cerebellar involvement and brain stem involvement had worse prognosis. Conclusion: HIE has an overall poor outcome in 83.3 % of the patients. Focal findings on MRI may have a slightly better prognosis than diffuse findings.http://www.sciencedirect.com/science/article/pii/S266645932500037XHypoxic ischemic encephalopathyLong term outcomeClinico-radiological correlation |
| spellingShingle | Saraswathi Ramanathan Prince Thakkar Harshad Vanjare Raji Thomas George Tharion Bijesh Yadav Non-perinatal hypoxic ischemic encephalopathy – Long term outcome and clinico-radiological correlation Brain Disorders Hypoxic ischemic encephalopathy Long term outcome Clinico-radiological correlation |
| title | Non-perinatal hypoxic ischemic encephalopathy – Long term outcome and clinico-radiological correlation |
| title_full | Non-perinatal hypoxic ischemic encephalopathy – Long term outcome and clinico-radiological correlation |
| title_fullStr | Non-perinatal hypoxic ischemic encephalopathy – Long term outcome and clinico-radiological correlation |
| title_full_unstemmed | Non-perinatal hypoxic ischemic encephalopathy – Long term outcome and clinico-radiological correlation |
| title_short | Non-perinatal hypoxic ischemic encephalopathy – Long term outcome and clinico-radiological correlation |
| title_sort | non perinatal hypoxic ischemic encephalopathy long term outcome and clinico radiological correlation |
| topic | Hypoxic ischemic encephalopathy Long term outcome Clinico-radiological correlation |
| url | http://www.sciencedirect.com/science/article/pii/S266645932500037X |
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