Platycodon grandiflorus polysaccharides deeply participate in the anti-chronic bronchitis effects of platycodon grandiflorus decoction, a representative of “the lung and intestine are related”
Platycodon grandiflorus (Jacq.) A. DC. (PG) root is one of the most commonly used medicine-food materials for respiratory discomfort in Asia, usually in the form of a decoction or leaching solution. As everyone knows, both of decoction and leaching solution is a polyphase dispersion system, containi...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.927384/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850041239578083328 |
|---|---|
| author | Yang Liu Qingqing Chen Rongrong Ren Qingqing Zhang Guiming Yan Dengke Yin Dengke Yin Mingyan Zhang Ye Yang Ye Yang Ye Yang |
| author_facet | Yang Liu Qingqing Chen Rongrong Ren Qingqing Zhang Guiming Yan Dengke Yin Dengke Yin Mingyan Zhang Ye Yang Ye Yang Ye Yang |
| author_sort | Yang Liu |
| collection | DOAJ |
| description | Platycodon grandiflorus (Jacq.) A. DC. (PG) root is one of the most commonly used medicine-food materials for respiratory discomfort in Asia, usually in the form of a decoction or leaching solution. As everyone knows, both of decoction and leaching solution is a polyphase dispersion system, containing low-molecular-weight water-soluble active ingredients and hydrophilic macromolecules. This study aimed to discuss the synergistic effect of Platycodon grandiflorus polysaccharide (PGP) and platycodin D (PD) in PG decoction against chronic bronchitis (CB) and the mechanism underlying. A series of PGP, PD, and PGD + PD suspensions were administrated to CB model rats, on the levels of whole animal and in situ intestinal segment with or without mesenteric lymphatic vessels ligation. It exhibited that PGP exhibited synergistic effects with PD, on improving the histopathological abnormity, mucus secretion excess, and immunological imbalance in lung of CB model rat, closely associated with its modulations on the mucosal immunity status in small intestine. The polysaccharide macromolecules in PG decoction or leaching solution should be responsible for the modulation of pulmonary immune state, possibly through the common mucosal immune between small intestine and lung. These results might be a new perspective that illustrates the classical theory of “the lung and intestine are related” in traditional Chinese medicine. |
| format | Article |
| id | doaj-art-e243b8781a6146efad769d2d4df94cf3 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-e243b8781a6146efad769d2d4df94cf32025-08-20T02:55:49ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-09-011310.3389/fphar.2022.927384927384Platycodon grandiflorus polysaccharides deeply participate in the anti-chronic bronchitis effects of platycodon grandiflorus decoction, a representative of “the lung and intestine are related”Yang Liu0Qingqing Chen1Rongrong Ren2Qingqing Zhang3Guiming Yan4Dengke Yin5Dengke Yin6Mingyan Zhang7Ye Yang8Ye Yang9Ye Yang10School of Pharmacy, Anhui University of Chinese Medicine, Hefei, ChinaSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, ChinaSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, ChinaSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, ChinaSchool of Nursing, Anhui University of Chinese Medicine, Hefei, ChinaSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, ChinaAnhui Provincial Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei, ChinaSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, ChinaSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, ChinaSchool of Nursing, Anhui University of Chinese Medicine, Hefei, ChinaState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, ChinaPlatycodon grandiflorus (Jacq.) A. DC. (PG) root is one of the most commonly used medicine-food materials for respiratory discomfort in Asia, usually in the form of a decoction or leaching solution. As everyone knows, both of decoction and leaching solution is a polyphase dispersion system, containing low-molecular-weight water-soluble active ingredients and hydrophilic macromolecules. This study aimed to discuss the synergistic effect of Platycodon grandiflorus polysaccharide (PGP) and platycodin D (PD) in PG decoction against chronic bronchitis (CB) and the mechanism underlying. A series of PGP, PD, and PGD + PD suspensions were administrated to CB model rats, on the levels of whole animal and in situ intestinal segment with or without mesenteric lymphatic vessels ligation. It exhibited that PGP exhibited synergistic effects with PD, on improving the histopathological abnormity, mucus secretion excess, and immunological imbalance in lung of CB model rat, closely associated with its modulations on the mucosal immunity status in small intestine. The polysaccharide macromolecules in PG decoction or leaching solution should be responsible for the modulation of pulmonary immune state, possibly through the common mucosal immune between small intestine and lung. These results might be a new perspective that illustrates the classical theory of “the lung and intestine are related” in traditional Chinese medicine.https://www.frontiersin.org/articles/10.3389/fphar.2022.927384/fullPlatycodon grandiflorus polysaccharidechronic bronchitiscommon mucosal immunitymesenteric lymphatic vessel ligationTh1/Th2 balance |
| spellingShingle | Yang Liu Qingqing Chen Rongrong Ren Qingqing Zhang Guiming Yan Dengke Yin Dengke Yin Mingyan Zhang Ye Yang Ye Yang Ye Yang Platycodon grandiflorus polysaccharides deeply participate in the anti-chronic bronchitis effects of platycodon grandiflorus decoction, a representative of “the lung and intestine are related” Frontiers in Pharmacology Platycodon grandiflorus polysaccharide chronic bronchitis common mucosal immunity mesenteric lymphatic vessel ligation Th1/Th2 balance |
| title | Platycodon grandiflorus polysaccharides deeply participate in the anti-chronic bronchitis effects of platycodon grandiflorus decoction, a representative of “the lung and intestine are related” |
| title_full | Platycodon grandiflorus polysaccharides deeply participate in the anti-chronic bronchitis effects of platycodon grandiflorus decoction, a representative of “the lung and intestine are related” |
| title_fullStr | Platycodon grandiflorus polysaccharides deeply participate in the anti-chronic bronchitis effects of platycodon grandiflorus decoction, a representative of “the lung and intestine are related” |
| title_full_unstemmed | Platycodon grandiflorus polysaccharides deeply participate in the anti-chronic bronchitis effects of platycodon grandiflorus decoction, a representative of “the lung and intestine are related” |
| title_short | Platycodon grandiflorus polysaccharides deeply participate in the anti-chronic bronchitis effects of platycodon grandiflorus decoction, a representative of “the lung and intestine are related” |
| title_sort | platycodon grandiflorus polysaccharides deeply participate in the anti chronic bronchitis effects of platycodon grandiflorus decoction a representative of the lung and intestine are related |
| topic | Platycodon grandiflorus polysaccharide chronic bronchitis common mucosal immunity mesenteric lymphatic vessel ligation Th1/Th2 balance |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.927384/full |
| work_keys_str_mv | AT yangliu platycodongrandifloruspolysaccharidesdeeplyparticipateintheantichronicbronchitiseffectsofplatycodongrandiflorusdecoctionarepresentativeofthelungandintestinearerelated AT qingqingchen platycodongrandifloruspolysaccharidesdeeplyparticipateintheantichronicbronchitiseffectsofplatycodongrandiflorusdecoctionarepresentativeofthelungandintestinearerelated AT rongrongren platycodongrandifloruspolysaccharidesdeeplyparticipateintheantichronicbronchitiseffectsofplatycodongrandiflorusdecoctionarepresentativeofthelungandintestinearerelated AT qingqingzhang platycodongrandifloruspolysaccharidesdeeplyparticipateintheantichronicbronchitiseffectsofplatycodongrandiflorusdecoctionarepresentativeofthelungandintestinearerelated AT guimingyan platycodongrandifloruspolysaccharidesdeeplyparticipateintheantichronicbronchitiseffectsofplatycodongrandiflorusdecoctionarepresentativeofthelungandintestinearerelated AT dengkeyin platycodongrandifloruspolysaccharidesdeeplyparticipateintheantichronicbronchitiseffectsofplatycodongrandiflorusdecoctionarepresentativeofthelungandintestinearerelated AT dengkeyin platycodongrandifloruspolysaccharidesdeeplyparticipateintheantichronicbronchitiseffectsofplatycodongrandiflorusdecoctionarepresentativeofthelungandintestinearerelated AT mingyanzhang platycodongrandifloruspolysaccharidesdeeplyparticipateintheantichronicbronchitiseffectsofplatycodongrandiflorusdecoctionarepresentativeofthelungandintestinearerelated AT yeyang platycodongrandifloruspolysaccharidesdeeplyparticipateintheantichronicbronchitiseffectsofplatycodongrandiflorusdecoctionarepresentativeofthelungandintestinearerelated AT yeyang platycodongrandifloruspolysaccharidesdeeplyparticipateintheantichronicbronchitiseffectsofplatycodongrandiflorusdecoctionarepresentativeofthelungandintestinearerelated AT yeyang platycodongrandifloruspolysaccharidesdeeplyparticipateintheantichronicbronchitiseffectsofplatycodongrandiflorusdecoctionarepresentativeofthelungandintestinearerelated |