Mechanisms and potential of mesenchymal stem cell-derived exosomes for treating radiation-induced intestinal injury
Radiation-induced intestinal injury (RIII) is a prevalent complication of radiotherapy for abdominal and pelvic tumors, characterized by acute and chronic damage to intestinal tissues. Current treatments are primarily symptomatic, lacking effective targeted therapies. Mesenchymal stem cells (MSCs),...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Extracellular Vesicle |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773041725000149 |
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| author | Tong An Daqin Li Ning Wang Feifei Ma Tuo Li Ningning He Huijuan Song Qiang Liu |
| author_facet | Tong An Daqin Li Ning Wang Feifei Ma Tuo Li Ningning He Huijuan Song Qiang Liu |
| author_sort | Tong An |
| collection | DOAJ |
| description | Radiation-induced intestinal injury (RIII) is a prevalent complication of radiotherapy for abdominal and pelvic tumors, characterized by acute and chronic damage to intestinal tissues. Current treatments are primarily symptomatic, lacking effective targeted therapies. Mesenchymal stem cells (MSCs), due to their immunomodulatory and regenerative properties, and their derived exosomes, have emerged as promising therapeutic options for RIII. MSC-derived exosomes exhibit anti-inflammatory, antioxidant, and tissue-repairing properties, modulating immune responses and promoting intestinal barrier restoration. Engineering of exosomes further enhances their targeting and therapeutic efficiency. This review discusses the mechanisms and therapeutic potential of MSC-derived and engineered exosomes for RIII, emphasizing their role in reducing inflammation, promoting tissue repair, and maintaining microbial balance, while addressing future challenges and prospects for clinical translation. |
| format | Article |
| id | doaj-art-e2422806e6b1487a84afc9962a0b7271 |
| institution | OA Journals |
| issn | 2773-0417 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Extracellular Vesicle |
| spelling | doaj-art-e2422806e6b1487a84afc9962a0b72712025-08-20T02:06:12ZengElsevierExtracellular Vesicle2773-04172025-06-01510007810.1016/j.vesic.2025.100078Mechanisms and potential of mesenchymal stem cell-derived exosomes for treating radiation-induced intestinal injuryTong An0Daqin Li1Ning Wang2Feifei Ma3Tuo Li4Ningning He5Huijuan Song6Qiang Liu7State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, ChinaState Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, ChinaSchool of Basic Medicine, Shandong Second Medical University, Weifang, 261053, ChinaSchool of Basic Medicine, Shandong Second Medical University, Weifang, 261053, ChinaSchool of Basic Medicine, Shandong Second Medical University, Weifang, 261053, ChinaState Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China; Corresponding author. Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin, 300192, China.State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China; Corresponding author. Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin, 300192, China.State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China; Corresponding author. Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin, 300192, China.Radiation-induced intestinal injury (RIII) is a prevalent complication of radiotherapy for abdominal and pelvic tumors, characterized by acute and chronic damage to intestinal tissues. Current treatments are primarily symptomatic, lacking effective targeted therapies. Mesenchymal stem cells (MSCs), due to their immunomodulatory and regenerative properties, and their derived exosomes, have emerged as promising therapeutic options for RIII. MSC-derived exosomes exhibit anti-inflammatory, antioxidant, and tissue-repairing properties, modulating immune responses and promoting intestinal barrier restoration. Engineering of exosomes further enhances their targeting and therapeutic efficiency. This review discusses the mechanisms and therapeutic potential of MSC-derived and engineered exosomes for RIII, emphasizing their role in reducing inflammation, promoting tissue repair, and maintaining microbial balance, while addressing future challenges and prospects for clinical translation.http://www.sciencedirect.com/science/article/pii/S2773041725000149Mesenchymal stem cellsExosomeExtracellular vesiclesRadiationIntestinal injury |
| spellingShingle | Tong An Daqin Li Ning Wang Feifei Ma Tuo Li Ningning He Huijuan Song Qiang Liu Mechanisms and potential of mesenchymal stem cell-derived exosomes for treating radiation-induced intestinal injury Extracellular Vesicle Mesenchymal stem cells Exosome Extracellular vesicles Radiation Intestinal injury |
| title | Mechanisms and potential of mesenchymal stem cell-derived exosomes for treating radiation-induced intestinal injury |
| title_full | Mechanisms and potential of mesenchymal stem cell-derived exosomes for treating radiation-induced intestinal injury |
| title_fullStr | Mechanisms and potential of mesenchymal stem cell-derived exosomes for treating radiation-induced intestinal injury |
| title_full_unstemmed | Mechanisms and potential of mesenchymal stem cell-derived exosomes for treating radiation-induced intestinal injury |
| title_short | Mechanisms and potential of mesenchymal stem cell-derived exosomes for treating radiation-induced intestinal injury |
| title_sort | mechanisms and potential of mesenchymal stem cell derived exosomes for treating radiation induced intestinal injury |
| topic | Mesenchymal stem cells Exosome Extracellular vesicles Radiation Intestinal injury |
| url | http://www.sciencedirect.com/science/article/pii/S2773041725000149 |
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