Oral microbiome components predict response to neoadjuvant chemotherapy in triple-negative breast cancer patients
The oral microbiome has emerged as a critical biomarker and regulator in cancer development and treatment response, garnering increasing attention from researchers. However, its specific role in breast cancer, particularly in triple-negative breast cancer (TNBC), remains poorly understood. The influ...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1546044/full |
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| author | Xiaoyan Fu Xiaoyan Fu Ze Huang Ze Huang Zongyan Li Zongyan Li Zuxiao Chen Zuxiao Chen Zhijie Wu Zhijie Wu Qingyu Yang Qingyu Yang Haiyan Li Haiyan Li |
| author_facet | Xiaoyan Fu Xiaoyan Fu Ze Huang Ze Huang Zongyan Li Zongyan Li Zuxiao Chen Zuxiao Chen Zhijie Wu Zhijie Wu Qingyu Yang Qingyu Yang Haiyan Li Haiyan Li |
| author_sort | Xiaoyan Fu |
| collection | DOAJ |
| description | The oral microbiome has emerged as a critical biomarker and regulator in cancer development and treatment response, garnering increasing attention from researchers. However, its specific role in breast cancer, particularly in triple-negative breast cancer (TNBC), remains poorly understood. The influence of the oral microbiome on chemotherapy sensitivity in TNBC, along with the underlying molecular mechanisms, remains unclear. Further investigation is needed to assess its potential as a biomarker for predicting chemotherapy sensitivity in this patient population. In the present study, significant differences in the composition of the oral microbiome were observed among patients with varying chemotherapy sensitivities for TNBC patients. Additionally, notable changes in the oral microbiome were noted after chemotherapy in patients with favorable responses to treatment. Our analysis revealed that chemotherapy-sensitive patients had higher levels of Lactobacillus and Neisseria species, alongside lower levels of Clostridium species. Post-chemotherapy, patients with positive responses demonstrated an increase in Clostridium and Microbacterium species, along with a decrease in Streptococcus and Neisseria. In contrast, no significant changes were observed in the microbiota of patients with poor chemotherapy responses. A classifier based on these microbial biomarkers yielded an area under the curve (AUC) value of 77.3% (95% CI: 60.5%-94.2%), supporting the potential of the oral microbiome as a predictive tool for chemotherapy sensitivity in TNBC. Given its simplicity, non-invasiveness, and repeatability, the oral microbiome holds promise as a valuable biomarker for predicting neoadjuvant chemotherapy sensitivity in TNBC patients. |
| format | Article |
| id | doaj-art-e241f6077b4e44ae9c600ba4330a25b7 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-e241f6077b4e44ae9c600ba4330a25b72025-08-20T03:51:53ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-07-011510.3389/fonc.2025.15460441546044Oral microbiome components predict response to neoadjuvant chemotherapy in triple-negative breast cancer patientsXiaoyan Fu0Xiaoyan Fu1Ze Huang2Ze Huang3Zongyan Li4Zongyan Li5Zuxiao Chen6Zuxiao Chen7Zhijie Wu8Zhijie Wu9Qingyu Yang10Qingyu Yang11Haiyan Li12Haiyan Li13Department of General Surgery (Breast Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaBiomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of General Surgery (Breast Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaBiomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of General Surgery (Breast Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaBiomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of General Surgery (Breast Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaBiomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of General Surgery (Breast Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaBiomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of General Surgery (Breast Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaBiomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of General Surgery (Breast Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaBiomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaThe oral microbiome has emerged as a critical biomarker and regulator in cancer development and treatment response, garnering increasing attention from researchers. However, its specific role in breast cancer, particularly in triple-negative breast cancer (TNBC), remains poorly understood. The influence of the oral microbiome on chemotherapy sensitivity in TNBC, along with the underlying molecular mechanisms, remains unclear. Further investigation is needed to assess its potential as a biomarker for predicting chemotherapy sensitivity in this patient population. In the present study, significant differences in the composition of the oral microbiome were observed among patients with varying chemotherapy sensitivities for TNBC patients. Additionally, notable changes in the oral microbiome were noted after chemotherapy in patients with favorable responses to treatment. Our analysis revealed that chemotherapy-sensitive patients had higher levels of Lactobacillus and Neisseria species, alongside lower levels of Clostridium species. Post-chemotherapy, patients with positive responses demonstrated an increase in Clostridium and Microbacterium species, along with a decrease in Streptococcus and Neisseria. In contrast, no significant changes were observed in the microbiota of patients with poor chemotherapy responses. A classifier based on these microbial biomarkers yielded an area under the curve (AUC) value of 77.3% (95% CI: 60.5%-94.2%), supporting the potential of the oral microbiome as a predictive tool for chemotherapy sensitivity in TNBC. Given its simplicity, non-invasiveness, and repeatability, the oral microbiome holds promise as a valuable biomarker for predicting neoadjuvant chemotherapy sensitivity in TNBC patients.https://www.frontiersin.org/articles/10.3389/fonc.2025.1546044/fulloral microbiometriple-negative breast cancerneoadjuvant chemotherapy sensitivityresponse-prediction modelbiomarker |
| spellingShingle | Xiaoyan Fu Xiaoyan Fu Ze Huang Ze Huang Zongyan Li Zongyan Li Zuxiao Chen Zuxiao Chen Zhijie Wu Zhijie Wu Qingyu Yang Qingyu Yang Haiyan Li Haiyan Li Oral microbiome components predict response to neoadjuvant chemotherapy in triple-negative breast cancer patients Frontiers in Oncology oral microbiome triple-negative breast cancer neoadjuvant chemotherapy sensitivity response-prediction model biomarker |
| title | Oral microbiome components predict response to neoadjuvant chemotherapy in triple-negative breast cancer patients |
| title_full | Oral microbiome components predict response to neoadjuvant chemotherapy in triple-negative breast cancer patients |
| title_fullStr | Oral microbiome components predict response to neoadjuvant chemotherapy in triple-negative breast cancer patients |
| title_full_unstemmed | Oral microbiome components predict response to neoadjuvant chemotherapy in triple-negative breast cancer patients |
| title_short | Oral microbiome components predict response to neoadjuvant chemotherapy in triple-negative breast cancer patients |
| title_sort | oral microbiome components predict response to neoadjuvant chemotherapy in triple negative breast cancer patients |
| topic | oral microbiome triple-negative breast cancer neoadjuvant chemotherapy sensitivity response-prediction model biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1546044/full |
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