Imaging of Acute Invasive Fungal Rhinosinusitis in a Patient with Gorlin Syndrome and Acute Lymphocytic Leukemia
Gorlin Syndrome (GS), also known as nevoid basal cell carcinoma syndrome, is a rare autosomal dominant condition characterized by developmental abnormalities and predisposition to certain neoplasms. Acute invasive fungal rhinosinusitis (AIFRS) is an uncommon clinical entity characterized by high mo...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Otolaryngology |
| Online Access: | http://dx.doi.org/10.1155/2013/272314 |
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| author | S. T. Donovan J. W. Thompson J. T. Sandlund E. E. Adderson E. K. Pivnick J. H. Harreld |
| author_facet | S. T. Donovan J. W. Thompson J. T. Sandlund E. E. Adderson E. K. Pivnick J. H. Harreld |
| author_sort | S. T. Donovan |
| collection | DOAJ |
| description | Gorlin Syndrome (GS), also known as nevoid basal cell carcinoma syndrome, is a rare autosomal dominant condition characterized by developmental abnormalities and predisposition to certain neoplasms. Acute invasive fungal rhinosinusitis (AIFRS) is an uncommon clinical entity characterized by high morbidity and mortality. In immunocompromised patients, computed tomography plays a critical role in screening for suspected AIFRS. However, due to the association between exposure to ionizing radiation and subsequent development of malignancies in patients with GS, patients with GS and suspected AIFRS present a unique and challenging clinical scenario. We present a case of a pediatric patient with GS and acute lymphocytic leukemia (ALL) diagnosed with AIFRS; to the best of our knowledge, it is the only case described in the literature. |
| format | Article |
| id | doaj-art-e24081a5deb54a7e83f952f129581f29 |
| institution | DOAJ |
| issn | 2090-6765 2090-6773 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Otolaryngology |
| spelling | doaj-art-e24081a5deb54a7e83f952f129581f292025-08-20T03:20:59ZengWileyCase Reports in Otolaryngology2090-67652090-67732013-01-01201310.1155/2013/272314272314Imaging of Acute Invasive Fungal Rhinosinusitis in a Patient with Gorlin Syndrome and Acute Lymphocytic LeukemiaS. T. Donovan0J. W. Thompson1J. T. Sandlund2E. E. Adderson3E. K. Pivnick4J. H. Harreld5Department of Otolaryngology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32608, USADepartment of Otolaryngology, University of Tennessee Health Sciences Center, 910 Madison Avenue, Memphis, TN 38163, USADepartment of Oncology, St. Jude Children’s Research Hospital, 262 Danny Thomas Boulevard, MS-260, Memphis, TN 38105, USADepartment of Infectious Diseases, St. Jude Children’s Research Hospital, 262 Danny Thomas Boulevard, MS-320, Memphis, TN 38105, USADepartments of Pediatrics and Ophthalmology, University of Tennessee Health Sciences Center, 711 Jefferson Avenue, Suite 523, Memphis, TN 38105, USADepartment of Radiological Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Boulevard, MS-220, Memphis, TN 38105, USAGorlin Syndrome (GS), also known as nevoid basal cell carcinoma syndrome, is a rare autosomal dominant condition characterized by developmental abnormalities and predisposition to certain neoplasms. Acute invasive fungal rhinosinusitis (AIFRS) is an uncommon clinical entity characterized by high morbidity and mortality. In immunocompromised patients, computed tomography plays a critical role in screening for suspected AIFRS. However, due to the association between exposure to ionizing radiation and subsequent development of malignancies in patients with GS, patients with GS and suspected AIFRS present a unique and challenging clinical scenario. We present a case of a pediatric patient with GS and acute lymphocytic leukemia (ALL) diagnosed with AIFRS; to the best of our knowledge, it is the only case described in the literature.http://dx.doi.org/10.1155/2013/272314 |
| spellingShingle | S. T. Donovan J. W. Thompson J. T. Sandlund E. E. Adderson E. K. Pivnick J. H. Harreld Imaging of Acute Invasive Fungal Rhinosinusitis in a Patient with Gorlin Syndrome and Acute Lymphocytic Leukemia Case Reports in Otolaryngology |
| title | Imaging of Acute Invasive Fungal Rhinosinusitis in a Patient with Gorlin Syndrome and Acute Lymphocytic Leukemia |
| title_full | Imaging of Acute Invasive Fungal Rhinosinusitis in a Patient with Gorlin Syndrome and Acute Lymphocytic Leukemia |
| title_fullStr | Imaging of Acute Invasive Fungal Rhinosinusitis in a Patient with Gorlin Syndrome and Acute Lymphocytic Leukemia |
| title_full_unstemmed | Imaging of Acute Invasive Fungal Rhinosinusitis in a Patient with Gorlin Syndrome and Acute Lymphocytic Leukemia |
| title_short | Imaging of Acute Invasive Fungal Rhinosinusitis in a Patient with Gorlin Syndrome and Acute Lymphocytic Leukemia |
| title_sort | imaging of acute invasive fungal rhinosinusitis in a patient with gorlin syndrome and acute lymphocytic leukemia |
| url | http://dx.doi.org/10.1155/2013/272314 |
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