Adverse health effects after breast cancer up to 14 years after diagnosis
Background: The number of breast cancer survivors increases, but information about long-term adverse health effects in breast cancer survivors is sparse. We aimed to get an overview of the health effects for which survivors visit their general practitioner up to 14 years after diagnosis. Methods: We...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Breast |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977624001966 |
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| author | Marianne J. Heins Kelly M. de Ligt Janneke Verloop Sabine Siesling Joke C. Korevaar Annette Berendsen Daan Brandenbarg Anneriet Dassen Agnes Jager Jacqueline Hugtenburg Gerda van der Weele |
| author_facet | Marianne J. Heins Kelly M. de Ligt Janneke Verloop Sabine Siesling Joke C. Korevaar Annette Berendsen Daan Brandenbarg Anneriet Dassen Agnes Jager Jacqueline Hugtenburg Gerda van der Weele |
| author_sort | Marianne J. Heins |
| collection | DOAJ |
| description | Background: The number of breast cancer survivors increases, but information about long-term adverse health effects in breast cancer survivors is sparse. We aimed to get an overview of the health effects for which survivors visit their general practitioner up to 14 years after diagnosis. Methods: We retrieved data on 11,495 women diagnosed with breast cancer in 2000–2016 and 23,242 age and sex matched controls from the PSCCR-Breast Cancer, a database containing data about cancer diagnosis, treatment and primary healthcare. We built Cox regression models for 685 health effects, with time until the health effect as the outcome and survivor/control and cancer treatment as predictors. Models were built separately for four age groups (aged 18/44, 45/59, 60/74 and 75/89) and two follow-up periods (1/4 and 5/14 years after diagnosis). Results: 148 health effects occurred statistically significantly more often in survivors than in controls (p < 0.05). Health effects varied by age, time since diagnosis and treatment, but osteoporosis, coughing, fatigue, skin and urinary infections, were statistically significantly increased in breast cancer survivors. Osteoporosis and chest symptoms were associated with hormone therapy; osteoporosis and skin infections with chemotherapy and lymphedema and skin infections with axillary dissection. Conclusions: Breast cancer survivors may experience numerous adverse health effects up to 14 years after diagnosis. Insight in individual risks may assist healthcare professionals in managing patient expectations and improve monitoring, detection and treatment of adverse health effects. |
| format | Article |
| id | doaj-art-e23fba73d75c417f989f067975714599 |
| institution | Kabale University |
| issn | 1532-3080 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj-art-e23fba73d75c417f989f0679757145992025-02-12T05:30:36ZengElsevierBreast1532-30802025-02-0179103865Adverse health effects after breast cancer up to 14 years after diagnosisMarianne J. Heins0Kelly M. de Ligt1Janneke Verloop2Sabine Siesling3Joke C. Korevaar4Annette Berendsen5Daan Brandenbarg6Anneriet Dassen7Agnes Jager8Jacqueline Hugtenburg9Gerda van der Weele10Nivel, Netherlands Institute of Health Services Research, Utrecht, the Netherlands; Corresponding author. Netherlands Institute for Health Services Research (NIVEL), P.O Box 1568, 3500 BN, Utrecht, the Netherlands.Department of Research and Development, Netherlands Comprehensive Cancer Organisation, Utrecht, the Netherlands; Department of Health Technology and Services Research, Technical Medical Centre, University of Twente, Enschede, the NetherlandsDepartment of Research and Development, Netherlands Comprehensive Cancer Organisation, Utrecht, the NetherlandsDepartment of Research and Development, Netherlands Comprehensive Cancer Organisation, Utrecht, the Netherlands; Department of Health Technology and Services Research, Technical Medical Centre, University of Twente, Enschede, the NetherlandsNivel, Netherlands Institute of Health Services Research, Utrecht, the NetherlandsDepartment of General Practice, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of General Practice, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of Surgery, Medisch Spectrum Twente, Enschede, the NetherlandsDepartment of Medical Oncology, ErasmusMC, Rotterdam, the NetherlandsDepartment of Clinical Pharmacology and Pharmacy, AmsterdamUMC, Amsterdam, the NetherlandsDutch College of General Practitioners (NHG), Utrecht, the NetherlandsBackground: The number of breast cancer survivors increases, but information about long-term adverse health effects in breast cancer survivors is sparse. We aimed to get an overview of the health effects for which survivors visit their general practitioner up to 14 years after diagnosis. Methods: We retrieved data on 11,495 women diagnosed with breast cancer in 2000–2016 and 23,242 age and sex matched controls from the PSCCR-Breast Cancer, a database containing data about cancer diagnosis, treatment and primary healthcare. We built Cox regression models for 685 health effects, with time until the health effect as the outcome and survivor/control and cancer treatment as predictors. Models were built separately for four age groups (aged 18/44, 45/59, 60/74 and 75/89) and two follow-up periods (1/4 and 5/14 years after diagnosis). Results: 148 health effects occurred statistically significantly more often in survivors than in controls (p < 0.05). Health effects varied by age, time since diagnosis and treatment, but osteoporosis, coughing, fatigue, skin and urinary infections, were statistically significantly increased in breast cancer survivors. Osteoporosis and chest symptoms were associated with hormone therapy; osteoporosis and skin infections with chemotherapy and lymphedema and skin infections with axillary dissection. Conclusions: Breast cancer survivors may experience numerous adverse health effects up to 14 years after diagnosis. Insight in individual risks may assist healthcare professionals in managing patient expectations and improve monitoring, detection and treatment of adverse health effects.http://www.sciencedirect.com/science/article/pii/S0960977624001966 |
| spellingShingle | Marianne J. Heins Kelly M. de Ligt Janneke Verloop Sabine Siesling Joke C. Korevaar Annette Berendsen Daan Brandenbarg Anneriet Dassen Agnes Jager Jacqueline Hugtenburg Gerda van der Weele Adverse health effects after breast cancer up to 14 years after diagnosis Breast |
| title | Adverse health effects after breast cancer up to 14 years after diagnosis |
| title_full | Adverse health effects after breast cancer up to 14 years after diagnosis |
| title_fullStr | Adverse health effects after breast cancer up to 14 years after diagnosis |
| title_full_unstemmed | Adverse health effects after breast cancer up to 14 years after diagnosis |
| title_short | Adverse health effects after breast cancer up to 14 years after diagnosis |
| title_sort | adverse health effects after breast cancer up to 14 years after diagnosis |
| url | http://www.sciencedirect.com/science/article/pii/S0960977624001966 |
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