TNF-α Promotes the Recovery of Dorsal Root Ganglion Neurons from Cisplatin-Induced Injury Through an NGF-Independent Mechanism
Nerve injury caused by chemotherapy drugs is a common side effect. How to reduce this kind of nerve injury and promote neuron recovery is of great significance. In this study, we found that tumor necrosis factor-α (TNF-α) promoted the recovery of dorsal root ganglion (DRG) neuron from cisplatin-indu...
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MDPI AG
2025-06-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/47/7/482 |
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| author | Yiling Wei Xianlin Xu Pan Wu Xiang Chen Qingmei Mo Ming Zhuo |
| author_facet | Yiling Wei Xianlin Xu Pan Wu Xiang Chen Qingmei Mo Ming Zhuo |
| author_sort | Yiling Wei |
| collection | DOAJ |
| description | Nerve injury caused by chemotherapy drugs is a common side effect. How to reduce this kind of nerve injury and promote neuron recovery is of great significance. In this study, we found that tumor necrosis factor-α (TNF-α) promoted the recovery of dorsal root ganglion (DRG) neuron from cisplatin-induced injury. On DRG neurons cultured in vitro, we found that TNF-α promoted neurite regeneration after cisplatin injury. In addition, TNF-α accelerated the removal of DNA damage and promoted the regeneration of mitochondria on DRG neurons. Study of the mechanism showed that this effect of TNF-α was independent from the NGF signaling pathway and occurred mostly through the activation of TNFR2 receptors, together with nucleus translocation of p65 and upregulation of NF-κB expression. This study provides a new theoretical basis and therapeutic strategy for the treatment of nerve injury caused by chemotherapy drugs. |
| format | Article |
| id | doaj-art-e23f1714c6cf4c799d756c48b4bc1e3d |
| institution | DOAJ |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Current Issues in Molecular Biology |
| spelling | doaj-art-e23f1714c6cf4c799d756c48b4bc1e3d2025-08-20T02:45:34ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-06-0147748210.3390/cimb47070482TNF-α Promotes the Recovery of Dorsal Root Ganglion Neurons from Cisplatin-Induced Injury Through an NGF-Independent MechanismYiling Wei0Xianlin Xu1Pan Wu2Xiang Chen3Qingmei Mo4Ming Zhuo5Medical School, Guizhou University, Guiyang 550000, ChinaDepartment of Biochemistry, School of Preclinical Medicine, Zunyi Medical University, Zunyi 563100, ChinaMedical School, Guizhou University, Guiyang 550000, ChinaMedical School, Guizhou University, Guiyang 550000, ChinaMedical School, Guizhou University, Guiyang 550000, ChinaMedical School, Guizhou University, Guiyang 550000, ChinaNerve injury caused by chemotherapy drugs is a common side effect. How to reduce this kind of nerve injury and promote neuron recovery is of great significance. In this study, we found that tumor necrosis factor-α (TNF-α) promoted the recovery of dorsal root ganglion (DRG) neuron from cisplatin-induced injury. On DRG neurons cultured in vitro, we found that TNF-α promoted neurite regeneration after cisplatin injury. In addition, TNF-α accelerated the removal of DNA damage and promoted the regeneration of mitochondria on DRG neurons. Study of the mechanism showed that this effect of TNF-α was independent from the NGF signaling pathway and occurred mostly through the activation of TNFR2 receptors, together with nucleus translocation of p65 and upregulation of NF-κB expression. This study provides a new theoretical basis and therapeutic strategy for the treatment of nerve injury caused by chemotherapy drugs.https://www.mdpi.com/1467-3045/47/7/482CIPNDRGtumor necrosis factor αneurite regenerationDNA damagemitochondrial damage |
| spellingShingle | Yiling Wei Xianlin Xu Pan Wu Xiang Chen Qingmei Mo Ming Zhuo TNF-α Promotes the Recovery of Dorsal Root Ganglion Neurons from Cisplatin-Induced Injury Through an NGF-Independent Mechanism Current Issues in Molecular Biology CIPN DRG tumor necrosis factor α neurite regeneration DNA damage mitochondrial damage |
| title | TNF-α Promotes the Recovery of Dorsal Root Ganglion Neurons from Cisplatin-Induced Injury Through an NGF-Independent Mechanism |
| title_full | TNF-α Promotes the Recovery of Dorsal Root Ganglion Neurons from Cisplatin-Induced Injury Through an NGF-Independent Mechanism |
| title_fullStr | TNF-α Promotes the Recovery of Dorsal Root Ganglion Neurons from Cisplatin-Induced Injury Through an NGF-Independent Mechanism |
| title_full_unstemmed | TNF-α Promotes the Recovery of Dorsal Root Ganglion Neurons from Cisplatin-Induced Injury Through an NGF-Independent Mechanism |
| title_short | TNF-α Promotes the Recovery of Dorsal Root Ganglion Neurons from Cisplatin-Induced Injury Through an NGF-Independent Mechanism |
| title_sort | tnf α promotes the recovery of dorsal root ganglion neurons from cisplatin induced injury through an ngf independent mechanism |
| topic | CIPN DRG tumor necrosis factor α neurite regeneration DNA damage mitochondrial damage |
| url | https://www.mdpi.com/1467-3045/47/7/482 |
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