Optimal Short-Time Acquisition Schemes in High Angular Resolution Diffusion-Weighted Imaging
This work investigates the possibilities of applying high-angular-resolution-diffusion-imaging- (HARDI-) based methods in a clinical setting by investigating the performance of non-Gaussian diffusion probability density function (PDF) estimation for a range of b-values and diffusion gradient directi...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2013/658583 |
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| author | V. Prčkovska H. C. Achterberg M. Bastiani P. Pullens E. Balmashnova B. M. ter Haar Romeny A. Vilanova A. Roebroeck |
| author_facet | V. Prčkovska H. C. Achterberg M. Bastiani P. Pullens E. Balmashnova B. M. ter Haar Romeny A. Vilanova A. Roebroeck |
| author_sort | V. Prčkovska |
| collection | DOAJ |
| description | This work investigates the possibilities of applying high-angular-resolution-diffusion-imaging- (HARDI-) based methods in a clinical setting by investigating the performance of non-Gaussian diffusion probability density function (PDF) estimation for a range of b-values and diffusion gradient direction tables. It does so at realistic SNR levels achievable in limited time on a high-performance 3T system for the whole human brain in vivo. We use both computational simulations and in vivo brain scans to quantify the angular resolution of two selected reconstruction methods: Q-ball imaging and the diffusion orientation transform. We propose a new analytical solution to the ODF derived from the DOT. Both techniques are analytical decomposition approaches that require identical acquisition and modest postprocessing times and, given the proposed modifications of the DOT, can be analyzed in a similar fashion. We find that an optimal HARDI protocol given a stringent time constraint (<10 min) combines a moderate b-value (around 2000 s/mm2) with a relatively low number of acquired directions (>48). Our findings generalize to other methods and additional improvements in MR acquisition techniques. |
| format | Article |
| id | doaj-art-e23b1c0bebd74396919ecec7ce177086 |
| institution | OA Journals |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-e23b1c0bebd74396919ecec7ce1770862025-08-20T02:21:16ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962013-01-01201310.1155/2013/658583658583Optimal Short-Time Acquisition Schemes in High Angular Resolution Diffusion-Weighted ImagingV. Prčkovska0H. C. Achterberg1M. Bastiani2P. Pullens3E. Balmashnova4B. M. ter Haar Romeny5A. Vilanova6A. Roebroeck7Department of BioMedical Engineering, Biomedical Image Analysis & Interpretation, Eindhoven University of Technology, Eindhoven, The NetherlandsDepartment of BioMedical Engineering, Biomedical Image Analysis & Interpretation, Eindhoven University of Technology, Eindhoven, The NetherlandsFaculty of Psychology & Neuroscience, Maastricht Brain Imaging Center, Maastricht University, Maastricht, The NetherlandsFaculty of Psychology & Neuroscience, Maastricht Brain Imaging Center, Maastricht University, Maastricht, The NetherlandsDepartment of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, The NetherlandsDepartment of BioMedical Engineering, Biomedical Image Analysis & Interpretation, Eindhoven University of Technology, Eindhoven, The NetherlandsDepartment of BioMedical Engineering, Biomedical Image Analysis & Interpretation, Eindhoven University of Technology, Eindhoven, The NetherlandsFaculty of Psychology & Neuroscience, Maastricht Brain Imaging Center, Maastricht University, Maastricht, The NetherlandsThis work investigates the possibilities of applying high-angular-resolution-diffusion-imaging- (HARDI-) based methods in a clinical setting by investigating the performance of non-Gaussian diffusion probability density function (PDF) estimation for a range of b-values and diffusion gradient direction tables. It does so at realistic SNR levels achievable in limited time on a high-performance 3T system for the whole human brain in vivo. We use both computational simulations and in vivo brain scans to quantify the angular resolution of two selected reconstruction methods: Q-ball imaging and the diffusion orientation transform. We propose a new analytical solution to the ODF derived from the DOT. Both techniques are analytical decomposition approaches that require identical acquisition and modest postprocessing times and, given the proposed modifications of the DOT, can be analyzed in a similar fashion. We find that an optimal HARDI protocol given a stringent time constraint (<10 min) combines a moderate b-value (around 2000 s/mm2) with a relatively low number of acquired directions (>48). Our findings generalize to other methods and additional improvements in MR acquisition techniques.http://dx.doi.org/10.1155/2013/658583 |
| spellingShingle | V. Prčkovska H. C. Achterberg M. Bastiani P. Pullens E. Balmashnova B. M. ter Haar Romeny A. Vilanova A. Roebroeck Optimal Short-Time Acquisition Schemes in High Angular Resolution Diffusion-Weighted Imaging International Journal of Biomedical Imaging |
| title | Optimal Short-Time Acquisition Schemes in High Angular Resolution Diffusion-Weighted Imaging |
| title_full | Optimal Short-Time Acquisition Schemes in High Angular Resolution Diffusion-Weighted Imaging |
| title_fullStr | Optimal Short-Time Acquisition Schemes in High Angular Resolution Diffusion-Weighted Imaging |
| title_full_unstemmed | Optimal Short-Time Acquisition Schemes in High Angular Resolution Diffusion-Weighted Imaging |
| title_short | Optimal Short-Time Acquisition Schemes in High Angular Resolution Diffusion-Weighted Imaging |
| title_sort | optimal short time acquisition schemes in high angular resolution diffusion weighted imaging |
| url | http://dx.doi.org/10.1155/2013/658583 |
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