The Effect of the Ideal Food Pyramid on Gut Microbiota in Rheumatoid Arthritis Patients
Background: The gut microbiota composition of rheumatoid arthritis (RA) patients differs from healthy people, and diet is among the powerful environmental determinants that can alter the microbiota. The purpose of this clinical research was to identify the effect of the Ideal Food Pyramid on gut mic...
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MDPI AG
2025-03-01
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| author | Ülger Kaçar Mutlutürk Betül Çiçek Gizem Cengiz |
| author_facet | Ülger Kaçar Mutlutürk Betül Çiçek Gizem Cengiz |
| author_sort | Ülger Kaçar Mutlutürk |
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| description | Background: The gut microbiota composition of rheumatoid arthritis (RA) patients differs from healthy people, and diet is among the powerful environmental determinants that can alter the microbiota. The purpose of this clinical research was to identify the effect of the Ideal Food Pyramid on gut microbiota in RA, as well as its impact on disease activity, biochemical findings and anthropometric measurements. Methods: Thirty patients diagnosed with RA that met the inclusion criteria were randomized into diet and control groups and followed for 12 weeks. The gut microbiota composition was indicated by 16SrRNA gene sequencing. Results: At the end of this study, Simpson, Shannon and Chao-1 indices were higher in the diet group (16) than in the control group (14), although not significantly (<i>p</i> > 0.05). In the diet group, at phylum levels, the abundance of <i>Bacteroides</i> decreased while the abundance of <i>Firmicutes</i> increased. At species level, <i>Prevotella copri</i>, <i>Bacteroides fragilis</i>, <i>Prevotella stercorea</i>, <i>Bacteroides uniformis</i> decreased, while <i>Faecalibacterium prausnitzii</i>, <i>Roseburia faecis</i>, <i>Bacteroides ovatus</i>, <i>Akkermansia muciniphila</i>, <i>Coprococcus eutactus</i>, <i>Gemmiger formicilis</i>, <i>Ruminococcus bromii</i>, and <i>Bifidobacterium longum</i> species increased in the diet group. Conclusions: The Ideal Food Pyramid has been determined to have many clinical benefits for RA patients, especially for the gut microbiota. |
| format | Article |
| id | doaj-art-e23a8dd501be46d28c4e576df9afceb9 |
| institution | DOAJ |
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| language | English |
| publishDate | 2025-03-01 |
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| spelling | doaj-art-e23a8dd501be46d28c4e576df9afceb92025-08-20T02:42:21ZengMDPI AGLife2075-17292025-03-0115346310.3390/life15030463The Effect of the Ideal Food Pyramid on Gut Microbiota in Rheumatoid Arthritis PatientsÜlger Kaçar Mutlutürk0Betül Çiçek1Gizem Cengiz2Department of Nutrition and Dietetics, Institute of Health Sciences, Erciyes University, Kayseri 38039, TürkiyeDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Erciyes University, Kayseri 38260, TürkiyeDivision of Rheumatology, Department of Physical Medicine and Rehabilitation, Medical Faculty Hospital, Erciyes University, Kayseri 38030, TürkiyeBackground: The gut microbiota composition of rheumatoid arthritis (RA) patients differs from healthy people, and diet is among the powerful environmental determinants that can alter the microbiota. The purpose of this clinical research was to identify the effect of the Ideal Food Pyramid on gut microbiota in RA, as well as its impact on disease activity, biochemical findings and anthropometric measurements. Methods: Thirty patients diagnosed with RA that met the inclusion criteria were randomized into diet and control groups and followed for 12 weeks. The gut microbiota composition was indicated by 16SrRNA gene sequencing. Results: At the end of this study, Simpson, Shannon and Chao-1 indices were higher in the diet group (16) than in the control group (14), although not significantly (<i>p</i> > 0.05). In the diet group, at phylum levels, the abundance of <i>Bacteroides</i> decreased while the abundance of <i>Firmicutes</i> increased. At species level, <i>Prevotella copri</i>, <i>Bacteroides fragilis</i>, <i>Prevotella stercorea</i>, <i>Bacteroides uniformis</i> decreased, while <i>Faecalibacterium prausnitzii</i>, <i>Roseburia faecis</i>, <i>Bacteroides ovatus</i>, <i>Akkermansia muciniphila</i>, <i>Coprococcus eutactus</i>, <i>Gemmiger formicilis</i>, <i>Ruminococcus bromii</i>, and <i>Bifidobacterium longum</i> species increased in the diet group. Conclusions: The Ideal Food Pyramid has been determined to have many clinical benefits for RA patients, especially for the gut microbiota.https://www.mdpi.com/2075-1729/15/3/463gut microbiotarheumatoid arthritisideal food pyramid |
| spellingShingle | Ülger Kaçar Mutlutürk Betül Çiçek Gizem Cengiz The Effect of the Ideal Food Pyramid on Gut Microbiota in Rheumatoid Arthritis Patients Life gut microbiota rheumatoid arthritis ideal food pyramid |
| title | The Effect of the Ideal Food Pyramid on Gut Microbiota in Rheumatoid Arthritis Patients |
| title_full | The Effect of the Ideal Food Pyramid on Gut Microbiota in Rheumatoid Arthritis Patients |
| title_fullStr | The Effect of the Ideal Food Pyramid on Gut Microbiota in Rheumatoid Arthritis Patients |
| title_full_unstemmed | The Effect of the Ideal Food Pyramid on Gut Microbiota in Rheumatoid Arthritis Patients |
| title_short | The Effect of the Ideal Food Pyramid on Gut Microbiota in Rheumatoid Arthritis Patients |
| title_sort | effect of the ideal food pyramid on gut microbiota in rheumatoid arthritis patients |
| topic | gut microbiota rheumatoid arthritis ideal food pyramid |
| url | https://www.mdpi.com/2075-1729/15/3/463 |
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