Decoding antibiotic resistance in Pseudomonas aeruginosa: Embracing innovative therapies beyond conventional antibiotics
Pseudomonas aeruginosa, an important Gram-negative opportunistic pathogen, is accountable for numerous acute and chronic infections, resulting in mortality rates of up to 40 % and significant morbidity. This opportunistic bacterial pathogen targets individuals with conditions like cystic fibrosis, b...
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Elsevier
2025-03-01
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| Series: | The Microbe |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950194625000019 |
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| author | Nomita Gupta Kanchan Chauhan Garima Singh Shobhi Chaudhary Jitendra Singh Rathore |
| author_facet | Nomita Gupta Kanchan Chauhan Garima Singh Shobhi Chaudhary Jitendra Singh Rathore |
| author_sort | Nomita Gupta |
| collection | DOAJ |
| description | Pseudomonas aeruginosa, an important Gram-negative opportunistic pathogen, is accountable for numerous acute and chronic infections, resulting in mortality rates of up to 40 % and significant morbidity. This opportunistic bacterial pathogen targets individuals with conditions like cystic fibrosis, burn wounds, chronic obstructive pulmonary disorder (COPD), immunodeficiency, cancer, and those experiencing severe infections requiring ventilation, such as in the case of COVID-19. Treatment with antibiotics is currently the only means of preventing P. aeruginosa infections. The pathogens acquired and adaptive mechanisms have led to a rise in the prevalence of multidrug-resistance, which poses a significant challenge in healthcare environments. The bacterial pathogen uses many strategies such as the formation of biofilms, multidrug resistance, and antibiotic tolerance, to spread and maintain infection. The mechanisms of intrinsic and adaptive resistance utilized by this microbe to empower its pathogenesis are covered in great detail in this review. The different antibiotics that are employed in clinical settings to treat P. aeruginosa infections are also discussed. Furthermore, various therapeutic strategies to treat P. aeruginosa infections such as phage therapy and CRISPR-Cas9, antimicrobial peptides, immunomodulators, use of nanotechnology, vaccine development, and the revolutionary concept of drug repurposing are well discussed. Coherently, we draw attention to the research on alternative as well as innovative methods to control P. aeruginosa infections replacing the need of traditionally available antibiotics. |
| format | Article |
| id | doaj-art-e237a064939c4657a8b4e90659d7778c |
| institution | Kabale University |
| issn | 2950-1946 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Microbe |
| spelling | doaj-art-e237a064939c4657a8b4e90659d7778c2025-08-20T03:42:55ZengElsevierThe Microbe2950-19462025-03-01610023310.1016/j.microb.2025.100233Decoding antibiotic resistance in Pseudomonas aeruginosa: Embracing innovative therapies beyond conventional antibioticsNomita Gupta0Kanchan Chauhan1Garima Singh2Shobhi Chaudhary3Jitendra Singh Rathore4Gautam Buddha University, School of Biotechnology, Yamuna Expressway, Greater Noida, Uttar Pradesh 201312, IndiaGautam Buddha University, School of Biotechnology, Yamuna Expressway, Greater Noida, Uttar Pradesh 201312, IndiaGautam Buddha University, School of Biotechnology, Yamuna Expressway, Greater Noida, Uttar Pradesh 201312, IndiaGautam Buddha University, School of Biotechnology, Yamuna Expressway, Greater Noida, Uttar Pradesh 201312, IndiaCorrespondence to: School of Biotechnology, Gautam Buddha University, Yamuna Expressway, Gautam Buddha Nagar, Greater Noida, Uttar Pradesh 201312, India.; Gautam Buddha University, School of Biotechnology, Yamuna Expressway, Greater Noida, Uttar Pradesh 201312, IndiaPseudomonas aeruginosa, an important Gram-negative opportunistic pathogen, is accountable for numerous acute and chronic infections, resulting in mortality rates of up to 40 % and significant morbidity. This opportunistic bacterial pathogen targets individuals with conditions like cystic fibrosis, burn wounds, chronic obstructive pulmonary disorder (COPD), immunodeficiency, cancer, and those experiencing severe infections requiring ventilation, such as in the case of COVID-19. Treatment with antibiotics is currently the only means of preventing P. aeruginosa infections. The pathogens acquired and adaptive mechanisms have led to a rise in the prevalence of multidrug-resistance, which poses a significant challenge in healthcare environments. The bacterial pathogen uses many strategies such as the formation of biofilms, multidrug resistance, and antibiotic tolerance, to spread and maintain infection. The mechanisms of intrinsic and adaptive resistance utilized by this microbe to empower its pathogenesis are covered in great detail in this review. The different antibiotics that are employed in clinical settings to treat P. aeruginosa infections are also discussed. Furthermore, various therapeutic strategies to treat P. aeruginosa infections such as phage therapy and CRISPR-Cas9, antimicrobial peptides, immunomodulators, use of nanotechnology, vaccine development, and the revolutionary concept of drug repurposing are well discussed. Coherently, we draw attention to the research on alternative as well as innovative methods to control P. aeruginosa infections replacing the need of traditionally available antibiotics.http://www.sciencedirect.com/science/article/pii/S2950194625000019P. aeruginosaAntibioticsResistanceTherapeuticsAntibiotic-free strategies |
| spellingShingle | Nomita Gupta Kanchan Chauhan Garima Singh Shobhi Chaudhary Jitendra Singh Rathore Decoding antibiotic resistance in Pseudomonas aeruginosa: Embracing innovative therapies beyond conventional antibiotics The Microbe P. aeruginosa Antibiotics Resistance Therapeutics Antibiotic-free strategies |
| title | Decoding antibiotic resistance in Pseudomonas aeruginosa: Embracing innovative therapies beyond conventional antibiotics |
| title_full | Decoding antibiotic resistance in Pseudomonas aeruginosa: Embracing innovative therapies beyond conventional antibiotics |
| title_fullStr | Decoding antibiotic resistance in Pseudomonas aeruginosa: Embracing innovative therapies beyond conventional antibiotics |
| title_full_unstemmed | Decoding antibiotic resistance in Pseudomonas aeruginosa: Embracing innovative therapies beyond conventional antibiotics |
| title_short | Decoding antibiotic resistance in Pseudomonas aeruginosa: Embracing innovative therapies beyond conventional antibiotics |
| title_sort | decoding antibiotic resistance in pseudomonas aeruginosa embracing innovative therapies beyond conventional antibiotics |
| topic | P. aeruginosa Antibiotics Resistance Therapeutics Antibiotic-free strategies |
| url | http://www.sciencedirect.com/science/article/pii/S2950194625000019 |
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