Gene frequencies and polymorphism of the MNS blood group system in the Han population of voluntary blood donors in Suzhou
[Objective] To investigate the antigen and gene frequency distribution of the MNS blood group system in the Han population of voluntary blood donors in Suzhou, and to explore the polymorphism of rare MNS blood group genes, in order to improve the construction of the local rare blood group database....
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2025-03-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.03.014&lang=en |
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| author | XU Zihao FU Xiaoyan LIU Zhen JIANG Jia JIN Yiming |
| author_facet | XU Zihao FU Xiaoyan LIU Zhen JIANG Jia JIN Yiming |
| author_sort | XU Zihao |
| collection | DOAJ |
| description | [Objective] To investigate the antigen and gene frequency distribution of the MNS blood group system in the Han population of voluntary blood donors in Suzhou, and to explore the polymorphism of rare MNS blood group genes, in order to improve the construction of the local rare blood group database. [Methods] A total of 8 034 whole blood samples were randomly collected from Han blood donors at our station from October 2023 to June 2024. The MNS blood group phenotypes were identified using serological methods. Gene frequencies were analyzed and compared with those of ethnic populations in other regions. Rare MNS phenotype samples were subjected to gene sequencing. [Results] The distribution of MNS blood group system phenotypes within the population was as follows: the MM, NN, and MN phenotypes accounted for 23.00%, 27.12%, and 49.88% respectively; the SS, ss, and Ss phenotypes accounted for 0.30%, 90.99%, and 8.70% respectively. The gene frequencies of M, N, S, and s were 0.4794, 0.5206, 0.0465, and 0.9534 respectively. Chi-squared tests confirmed adherence to Hardy-Weinberg equilibrium with P-values of 0.997 and 0.349, showing statistical significance compared to some other regional ethnic populations (P<0.05). Additionally, one rare serological phenotype, S-s-, with a frequency of 0.01%, was identified. [Conclusion] The MNS blood group system in the Han population of voluntary blood donors in Suzhou exhibits polymorphism and regional distribution characteristics. Gene frequencies differ from those observed in other regions of China. It is essential to enhance the establishment of a rare blood type database in Suzhou to provide data support for precise clinical transfusion. |
| format | Article |
| id | doaj-art-e23749becb25461d8ea99b6024007e34 |
| institution | OA Journals |
| issn | 1004-549X |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-e23749becb25461d8ea99b6024007e342025-08-20T01:51:28ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2025-03-0138339740110.13303/j.cjbt.issn.1004-549x.2025.03.0141004-549X(2025)3-0397-06Gene frequencies and polymorphism of the MNS blood group system in the Han population of voluntary blood donors in SuzhouXU Zihao0FU Xiaoyan1LIU Zhen2JIANG Jia3JIN Yiming4Suzhou Blood Center, Suzhou 215000, ChinaTai Cang Blood Branch Station, Taicang 215400, ChinaSuzhou Blood Center, Suzhou 215000, ChinaSuzhou Blood Center, Suzhou 215000, ChinaSuzhou Blood Center, Suzhou 215000, China[Objective] To investigate the antigen and gene frequency distribution of the MNS blood group system in the Han population of voluntary blood donors in Suzhou, and to explore the polymorphism of rare MNS blood group genes, in order to improve the construction of the local rare blood group database. [Methods] A total of 8 034 whole blood samples were randomly collected from Han blood donors at our station from October 2023 to June 2024. The MNS blood group phenotypes were identified using serological methods. Gene frequencies were analyzed and compared with those of ethnic populations in other regions. Rare MNS phenotype samples were subjected to gene sequencing. [Results] The distribution of MNS blood group system phenotypes within the population was as follows: the MM, NN, and MN phenotypes accounted for 23.00%, 27.12%, and 49.88% respectively; the SS, ss, and Ss phenotypes accounted for 0.30%, 90.99%, and 8.70% respectively. The gene frequencies of M, N, S, and s were 0.4794, 0.5206, 0.0465, and 0.9534 respectively. Chi-squared tests confirmed adherence to Hardy-Weinberg equilibrium with P-values of 0.997 and 0.349, showing statistical significance compared to some other regional ethnic populations (P<0.05). Additionally, one rare serological phenotype, S-s-, with a frequency of 0.01%, was identified. [Conclusion] The MNS blood group system in the Han population of voluntary blood donors in Suzhou exhibits polymorphism and regional distribution characteristics. Gene frequencies differ from those observed in other regions of China. It is essential to enhance the establishment of a rare blood type database in Suzhou to provide data support for precise clinical transfusion.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.03.014&lang=enmns blood group systemrare blood groupgene frequencygene polymorphism |
| spellingShingle | XU Zihao FU Xiaoyan LIU Zhen JIANG Jia JIN Yiming Gene frequencies and polymorphism of the MNS blood group system in the Han population of voluntary blood donors in Suzhou Zhongguo shuxue zazhi mns blood group system rare blood group gene frequency gene polymorphism |
| title | Gene frequencies and polymorphism of the MNS blood group system in the Han population of voluntary blood donors in Suzhou |
| title_full | Gene frequencies and polymorphism of the MNS blood group system in the Han population of voluntary blood donors in Suzhou |
| title_fullStr | Gene frequencies and polymorphism of the MNS blood group system in the Han population of voluntary blood donors in Suzhou |
| title_full_unstemmed | Gene frequencies and polymorphism of the MNS blood group system in the Han population of voluntary blood donors in Suzhou |
| title_short | Gene frequencies and polymorphism of the MNS blood group system in the Han population of voluntary blood donors in Suzhou |
| title_sort | gene frequencies and polymorphism of the mns blood group system in the han population of voluntary blood donors in suzhou |
| topic | mns blood group system rare blood group gene frequency gene polymorphism |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.03.014&lang=en |
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