Genetic Association Between High‐Risk HPV (HPV16 and HPV18) Infection and Tumor Development: A Mendelian Randomization Analysis
ABSTRACT Background and Aims Observational and experimental studies have provided substantial evidence supporting a link between cervical cancer and human papillomavirus (HPV) infection. Nevertheless, there is uncertainty regarding the association of benign and malignant cancers with HPV infection....
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-04-01
|
| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.70704 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850205673067905024 |
|---|---|
| author | You Wu Haiyang Xia Feng Du Jian Zhang Xulin Jiang Jun Tang Zhihong Li |
| author_facet | You Wu Haiyang Xia Feng Du Jian Zhang Xulin Jiang Jun Tang Zhihong Li |
| author_sort | You Wu |
| collection | DOAJ |
| description | ABSTRACT Background and Aims Observational and experimental studies have provided substantial evidence supporting a link between cervical cancer and human papillomavirus (HPV) infection. Nevertheless, there is uncertainty regarding the association of benign and malignant cancers with HPV infection. Methods The study was divided into two approaches, Mendelian randomization (MR) and multivariate Mendelian randomization (MVMR), to investigate the link between HPV and both benign and malignant cancers. This study employed genetic variants as instrumental variables to mitigate potential biases arising from confounding factors and reverse causality. In 338 cases and 1000 controls in the European ancestry of Germany, independent genetic variations were identified as having a substantial correlation (p < 5 × 10−5) with exposure and HPV infection. The outcome variables data of various carcinomas were acquired from the Genome‐wide association summary data. Meanwhile, benign tumors from the FinnGen and UK Biobank (UKB) consortium were acquired as well. Results Following correction for multiple testing, the MVMR method was employed and the causal association was investigated between genetic liability to HPV infection and various malignancies, including bone and articular cartilage, bladder cancer, secondary malignant neoplasm of the liver, prostate cancer, as well as benign tumors including melanocytic naevi of the lip, brain, bronchus and lung, lip, mouth and pharynx, pancreas, and haemangioma and lymphangioma, and female genitalia. Conclusions From a genetic standpoint, HPV may contributes to the formation of benign and malignant tumors in female genital cancer as well as malignancies in other regions of the body, which should inform public health policy. |
| format | Article |
| id | doaj-art-e23536fc2ef84fc5a81e556d51885b44 |
| institution | OA Journals |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-e23536fc2ef84fc5a81e556d51885b442025-08-20T02:11:03ZengWileyHealth Science Reports2398-88352025-04-0184n/an/a10.1002/hsr2.70704Genetic Association Between High‐Risk HPV (HPV16 and HPV18) Infection and Tumor Development: A Mendelian Randomization AnalysisYou Wu0Haiyang Xia1Feng Du2Jian Zhang3Xulin Jiang4Jun Tang5Zhihong Li6Department of Gastrointestinal Surgery Ezhou Central Hospital, Affiliated to Hubei University of Science and Technology Ezhou Hubei People Republic of ChinaDepartment of Gastrointestinal Surgery Ezhou Central Hospital, Affiliated to Hubei University of Science and Technology Ezhou Hubei People Republic of ChinaDepartment of Gastrointestinal Surgery Ezhou Central Hospital, Affiliated to Hubei University of Science and Technology Ezhou Hubei People Republic of ChinaDepartment of Gastrointestinal Surgery Ezhou Central Hospital, Affiliated to Hubei University of Science and Technology Ezhou Hubei People Republic of ChinaDepartment of Gastrointestinal Surgery Ezhou Central Hospital, Affiliated to Hubei University of Science and Technology Ezhou Hubei People Republic of ChinaDepartment of Gastrointestinal Surgery Ezhou Central Hospital, Affiliated to Hubei University of Science and Technology Ezhou Hubei People Republic of ChinaDepartment of Gastrointestinal Surgery Ezhou Central Hospital, Affiliated to Hubei University of Science and Technology Ezhou Hubei People Republic of ChinaABSTRACT Background and Aims Observational and experimental studies have provided substantial evidence supporting a link between cervical cancer and human papillomavirus (HPV) infection. Nevertheless, there is uncertainty regarding the association of benign and malignant cancers with HPV infection. Methods The study was divided into two approaches, Mendelian randomization (MR) and multivariate Mendelian randomization (MVMR), to investigate the link between HPV and both benign and malignant cancers. This study employed genetic variants as instrumental variables to mitigate potential biases arising from confounding factors and reverse causality. In 338 cases and 1000 controls in the European ancestry of Germany, independent genetic variations were identified as having a substantial correlation (p < 5 × 10−5) with exposure and HPV infection. The outcome variables data of various carcinomas were acquired from the Genome‐wide association summary data. Meanwhile, benign tumors from the FinnGen and UK Biobank (UKB) consortium were acquired as well. Results Following correction for multiple testing, the MVMR method was employed and the causal association was investigated between genetic liability to HPV infection and various malignancies, including bone and articular cartilage, bladder cancer, secondary malignant neoplasm of the liver, prostate cancer, as well as benign tumors including melanocytic naevi of the lip, brain, bronchus and lung, lip, mouth and pharynx, pancreas, and haemangioma and lymphangioma, and female genitalia. Conclusions From a genetic standpoint, HPV may contributes to the formation of benign and malignant tumors in female genital cancer as well as malignancies in other regions of the body, which should inform public health policy.https://doi.org/10.1002/hsr2.70704cancersHPVhuman papillomavirusMendelian randomizationneoplasms |
| spellingShingle | You Wu Haiyang Xia Feng Du Jian Zhang Xulin Jiang Jun Tang Zhihong Li Genetic Association Between High‐Risk HPV (HPV16 and HPV18) Infection and Tumor Development: A Mendelian Randomization Analysis Health Science Reports cancers HPV human papillomavirus Mendelian randomization neoplasms |
| title | Genetic Association Between High‐Risk HPV (HPV16 and HPV18) Infection and Tumor Development: A Mendelian Randomization Analysis |
| title_full | Genetic Association Between High‐Risk HPV (HPV16 and HPV18) Infection and Tumor Development: A Mendelian Randomization Analysis |
| title_fullStr | Genetic Association Between High‐Risk HPV (HPV16 and HPV18) Infection and Tumor Development: A Mendelian Randomization Analysis |
| title_full_unstemmed | Genetic Association Between High‐Risk HPV (HPV16 and HPV18) Infection and Tumor Development: A Mendelian Randomization Analysis |
| title_short | Genetic Association Between High‐Risk HPV (HPV16 and HPV18) Infection and Tumor Development: A Mendelian Randomization Analysis |
| title_sort | genetic association between high risk hpv hpv16 and hpv18 infection and tumor development a mendelian randomization analysis |
| topic | cancers HPV human papillomavirus Mendelian randomization neoplasms |
| url | https://doi.org/10.1002/hsr2.70704 |
| work_keys_str_mv | AT youwu geneticassociationbetweenhighriskhpvhpv16andhpv18infectionandtumordevelopmentamendelianrandomizationanalysis AT haiyangxia geneticassociationbetweenhighriskhpvhpv16andhpv18infectionandtumordevelopmentamendelianrandomizationanalysis AT fengdu geneticassociationbetweenhighriskhpvhpv16andhpv18infectionandtumordevelopmentamendelianrandomizationanalysis AT jianzhang geneticassociationbetweenhighriskhpvhpv16andhpv18infectionandtumordevelopmentamendelianrandomizationanalysis AT xulinjiang geneticassociationbetweenhighriskhpvhpv16andhpv18infectionandtumordevelopmentamendelianrandomizationanalysis AT juntang geneticassociationbetweenhighriskhpvhpv16andhpv18infectionandtumordevelopmentamendelianrandomizationanalysis AT zhihongli geneticassociationbetweenhighriskhpvhpv16andhpv18infectionandtumordevelopmentamendelianrandomizationanalysis |