Impact of CYP3A4 functional variability on ziprasidone metabolism

Impact of CYP3A4 functional variability on ziprasidone metabolism

IntroductionZiprasidone is primarily metabolized by CYP3A4, an enzyme with genetic variability and susceptibility to inhibition or induction. This study explored the functional variability of CYP3A4 in ziprasidone metabolism, focusing on drug interactions and genetic polymorphisms.MethodsThe metabol...

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Bibliographic Details
Main Authors: Qi Zhou, Yameng Wu, Zhize Ye, Zheyan Zhang, Kai Zheng, Jianchang Qian, Zhongxiang Xiao, Yang Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
ziprasidone
quercetin
drug-drug interaction
CYP3A4
LC-MS/MS
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1585040/full
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