Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives
Regulated necrosis is defined as cell death characterized by loss of the cell membrane integrity and release of the cytoplasmic content. It contributes to the development and progression of some diseases, including ischemic stroke injury, liver diseases, hypertension, and cancer. Various forms of re...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2022/2695212 |
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| _version_ | 1832565477284511744 |
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| author | Wanying Lin Minting Chen Yacouba Cissé Xiaofeng Chen Lang Bai |
| author_facet | Wanying Lin Minting Chen Yacouba Cissé Xiaofeng Chen Lang Bai |
| author_sort | Wanying Lin |
| collection | DOAJ |
| description | Regulated necrosis is defined as cell death characterized by loss of the cell membrane integrity and release of the cytoplasmic content. It contributes to the development and progression of some diseases, including ischemic stroke injury, liver diseases, hypertension, and cancer. Various forms of regulated necrosis, particularly pyroptosis, necroptosis, and ferroptosis, have been implicated in the pathogenesis of corneal disease. Regulated necrosis of corneal cells enhances inflammatory reactions in the adjacent corneal tissues, leading to recurrence and aggravation of corneal disease. In this review, we summarize the molecular mechanisms of pyroptosis, necroptosis, and ferroptosis in corneal diseases and discuss the roles of regulated necrosis in inflammation regulation, tissue repair, and corneal disease outcomes. |
| format | Article |
| id | doaj-art-e231be6eb8864d318049fa81fc217924 |
| institution | Kabale University |
| issn | 2090-0058 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-e231be6eb8864d318049fa81fc2179242025-02-03T01:07:36ZengWileyJournal of Ophthalmology2090-00582022-01-01202210.1155/2022/2695212Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and PerspectivesWanying Lin0Minting Chen1Yacouba Cissé2Xiaofeng Chen3Lang Bai4Department of OphthalmologyDepartment of OphthalmologyDepartment of OphthalmologyDepartment of OphthalmologyDepartment of OphthalmologyRegulated necrosis is defined as cell death characterized by loss of the cell membrane integrity and release of the cytoplasmic content. It contributes to the development and progression of some diseases, including ischemic stroke injury, liver diseases, hypertension, and cancer. Various forms of regulated necrosis, particularly pyroptosis, necroptosis, and ferroptosis, have been implicated in the pathogenesis of corneal disease. Regulated necrosis of corneal cells enhances inflammatory reactions in the adjacent corneal tissues, leading to recurrence and aggravation of corneal disease. In this review, we summarize the molecular mechanisms of pyroptosis, necroptosis, and ferroptosis in corneal diseases and discuss the roles of regulated necrosis in inflammation regulation, tissue repair, and corneal disease outcomes.http://dx.doi.org/10.1155/2022/2695212 |
| spellingShingle | Wanying Lin Minting Chen Yacouba Cissé Xiaofeng Chen Lang Bai Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives Journal of Ophthalmology |
| title | Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives |
| title_full | Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives |
| title_fullStr | Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives |
| title_full_unstemmed | Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives |
| title_short | Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives |
| title_sort | roles and mechanisms of regulated necrosis in corneal diseases progress and perspectives |
| url | http://dx.doi.org/10.1155/2022/2695212 |
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