Investigations of amination reactions on an antimalarial 1,2,4-triazolo[4,3-a]pyrazine scaffold

1,2,4-Triazolo[4,3-a]pyrazines have previously been explored by the Open Source Malaria project as potent in vitro and in vivo antimalarial drug leads. With a view to generating a library of unique antimalarial 1,2,4-triazolo[4,3-a]pyrazines and exploring regiochemical preference for nucleophilic am...

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Bibliographic Details
Main Authors: Henry S. T. Smith, Ben Giuliani, Kanchana Wijesekera, Kah Yean Lum, Sandra Duffy, Aaron Lock, Jonathan M. White, Vicky M. Avery, Rohan A. Davis
Format: Article
Language:English
Published: Beilstein-Institut 2025-06-01
Series:Beilstein Journal of Organic Chemistry
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Online Access:https://doi.org/10.3762/bjoc.21.90
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