Inhibition of BRD4 prevents peribronchial fibrosis in mice with cutaneous lewisite exposure

Inhibition of BRD4 prevents peribronchial fibrosis in mice with cutaneous lewisite exposure

IntroductionArsenicals like lewisite are highly toxic vesicant chemical warfare agents that cause severe skin damage and systemic inflammation. Exposure activates cytokine release, leading to pulmonary injury, including edema, hemorrhage, and in severe cases, Bronchiolitis Obliterans Syndrome (BOS),...

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Bibliographic Details
Main Authors: Huaxiu Zeng, Pooja Singh, Rajesh Sinha, Crystal T. Stephens, Aftab Ahmad, Mohammad Athar, Veena B. Antony
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
arsenical
BRD4 inhibitor
CPI-0610
lewisite
pulmonary fibrosis
fibrotic
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1644792/full
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