Clinical case of combined malignant neoplasm of the cervix: neuroendocrine carcinoma and squamous cell cancer
Neuroendocrine carcinomas are rare and aggressive types of cervical tumors. Available literature contains limited descriptions of mixed carcinomas, and knowledge about this type of mixed carcinoma remains limited. Morphological diagnosis of this carcinoma type can be difficult due to the fact that n...
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| Format: | Article |
| Language: | Russian |
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Private institution educational organization of higher education "Medical University "ReaViz"
2025-08-01
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| Series: | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
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| Online Access: | https://vestnik.reaviz.ru/jour/article/view/1272 |
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| author | T. A. Garkusha A. N. Zagrebel'nikova V. N. Shelepova F. V. Alyab'ev N. V. Khludneva |
| author_facet | T. A. Garkusha A. N. Zagrebel'nikova V. N. Shelepova F. V. Alyab'ev N. V. Khludneva |
| author_sort | T. A. Garkusha |
| collection | DOAJ |
| description | Neuroendocrine carcinomas are rare and aggressive types of cervical tumors. Available literature contains limited descriptions of mixed carcinomas, and knowledge about this type of mixed carcinoma remains limited. Morphological diagnosis of this carcinoma type can be difficult due to the fact that neuroendocrine carcinoma cells can resemble squamous cell carcinoma. Additional complications can be caused by the lack of expression of some specific neuroendocrine markers. Incorrect diagnosis of this carcinoma can lead to incorrect patient management tactics or treatment delays. This article presents a clinical observation of a 45-year-old female patient who was diagnosed with mixed neuroendocrine and squamous cell carcinoma of the cervix, HPV-associated, with multiple metastases. This case is of particular interest due to the rarity of this pathology and diagnostics challenges it presents. |
| format | Article |
| id | doaj-art-e22b4243beb8440e9269c7a42d2d3c5a |
| institution | Kabale University |
| issn | 2226-762X 2782-1579 |
| language | Russian |
| publishDate | 2025-08-01 |
| publisher | Private institution educational organization of higher education "Medical University "ReaViz" |
| record_format | Article |
| series | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| spelling | doaj-art-e22b4243beb8440e9269c7a42d2d3c5a2025-08-20T03:59:21ZrusPrivate institution educational organization of higher education "Medical University "ReaViz"Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье2226-762X2782-15792025-08-0115315115510.20340/vmi-rvz.2025.3.MORPH.2773Clinical case of combined malignant neoplasm of the cervix: neuroendocrine carcinoma and squamous cell cancerT. A. Garkusha0A. N. Zagrebel'nikova1V. N. Shelepova2F. V. Alyab'ev3N. V. Khludneva4Krasnoyarsk State Medical University named after Professor V. F. Voyno-Yasenetsky; Krasnoyarsk Regional Pathological Anatomy BureauKrasnoyarsk State Medical University named after Professor V. F. Voyno-YasenetskyKrasnoyarsk State Medical University named after Professor V. F. Voyno-YasenetskyKrasnoyarsk State Medical University named after Professor V. F. Voyno-YasenetskyKrasnoyarsk State Medical University named after Professor V. F. Voyno-YasenetskyNeuroendocrine carcinomas are rare and aggressive types of cervical tumors. Available literature contains limited descriptions of mixed carcinomas, and knowledge about this type of mixed carcinoma remains limited. Morphological diagnosis of this carcinoma type can be difficult due to the fact that neuroendocrine carcinoma cells can resemble squamous cell carcinoma. Additional complications can be caused by the lack of expression of some specific neuroendocrine markers. Incorrect diagnosis of this carcinoma can lead to incorrect patient management tactics or treatment delays. This article presents a clinical observation of a 45-year-old female patient who was diagnosed with mixed neuroendocrine and squamous cell carcinoma of the cervix, HPV-associated, with multiple metastases. This case is of particular interest due to the rarity of this pathology and diagnostics challenges it presents.https://vestnik.reaviz.ru/jour/article/view/1272malignant neoplasm / neoplasmsmalignant [c04.557]mixed carcinoma / carcinoma [c04.557.470.200.025]cervical carcinoma / uterine cervical neoplasms [c04.588.322.894]neuroendocrine carcinoma / carcinomaneuroendocrine [c04.557.470.200.025.330]squamous cell carcinoma / carcinomasquamous cell [c04.557.470.200.025.700]human papillomavirus / papillomavirus infections [c02.256.743]metastases / neoplasm metastasis [c04.697.645]immunohistochemistry [e01.370.225.500.384.100]morphological diagnosis / pathologyclinical [h02.403.670]clinical case / case reports [v02.600.300.200] |
| spellingShingle | T. A. Garkusha A. N. Zagrebel'nikova V. N. Shelepova F. V. Alyab'ev N. V. Khludneva Clinical case of combined malignant neoplasm of the cervix: neuroendocrine carcinoma and squamous cell cancer Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье malignant neoplasm / neoplasms malignant [c04.557] mixed carcinoma / carcinoma [c04.557.470.200.025] cervical carcinoma / uterine cervical neoplasms [c04.588.322.894] neuroendocrine carcinoma / carcinoma neuroendocrine [c04.557.470.200.025.330] squamous cell carcinoma / carcinoma squamous cell [c04.557.470.200.025.700] human papillomavirus / papillomavirus infections [c02.256.743] metastases / neoplasm metastasis [c04.697.645] immunohistochemistry [e01.370.225.500.384.100] morphological diagnosis / pathology clinical [h02.403.670] clinical case / case reports [v02.600.300.200] |
| title | Clinical case of combined malignant neoplasm of the cervix: neuroendocrine carcinoma and squamous cell cancer |
| title_full | Clinical case of combined malignant neoplasm of the cervix: neuroendocrine carcinoma and squamous cell cancer |
| title_fullStr | Clinical case of combined malignant neoplasm of the cervix: neuroendocrine carcinoma and squamous cell cancer |
| title_full_unstemmed | Clinical case of combined malignant neoplasm of the cervix: neuroendocrine carcinoma and squamous cell cancer |
| title_short | Clinical case of combined malignant neoplasm of the cervix: neuroendocrine carcinoma and squamous cell cancer |
| title_sort | clinical case of combined malignant neoplasm of the cervix neuroendocrine carcinoma and squamous cell cancer |
| topic | malignant neoplasm / neoplasms malignant [c04.557] mixed carcinoma / carcinoma [c04.557.470.200.025] cervical carcinoma / uterine cervical neoplasms [c04.588.322.894] neuroendocrine carcinoma / carcinoma neuroendocrine [c04.557.470.200.025.330] squamous cell carcinoma / carcinoma squamous cell [c04.557.470.200.025.700] human papillomavirus / papillomavirus infections [c02.256.743] metastases / neoplasm metastasis [c04.697.645] immunohistochemistry [e01.370.225.500.384.100] morphological diagnosis / pathology clinical [h02.403.670] clinical case / case reports [v02.600.300.200] |
| url | https://vestnik.reaviz.ru/jour/article/view/1272 |
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