High leafy and root vegetables and high rice dietary patterns were associated with primary and secondary bile acid levels in the feces

Abstract Colorectal cancer has the second highest mortality among cancer sites worldwide, with increasing morbidity, high recurrence rates, and even poorer postoperative quality of life. Therefore, preventive strategies for colorectal cancer should be established. This study aimed to cross-sectional...

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Main Authors: Yosuke Saito, Toyoaki Sagae
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-025-86273-8
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author Yosuke Saito
Toyoaki Sagae
author_facet Yosuke Saito
Toyoaki Sagae
author_sort Yosuke Saito
collection DOAJ
description Abstract Colorectal cancer has the second highest mortality among cancer sites worldwide, with increasing morbidity, high recurrence rates, and even poorer postoperative quality of life. Therefore, preventive strategies for colorectal cancer should be established. This study aimed to cross-sectionally explore dietary patterns affecting the intestinal metabolism of bile acids (BAs), a risk factor for colorectal cancer, in young Japanese women. We collected fecal samples for intestinal microbiota and BA analysis. We used the Bristol scale to determine 1-week defecation status. Moreover, the brief-type self-administered diet history questionnaire was used for habitual dietary intake status. Reduced-rank regression analysis revealed dietary patterns related to fecal BA levels. The relationship between dietary patterns and fecal BA levels was adjusted for defecation status and intestinal microbiota variables using analysis of covariance. Reduced-rank regression analysis generated two dietary pattern scores related to fecal BA levels. First, the score was associated with a greater intake of leafy and root vegetables, and higher values were associated with greater fecal cholic and chenodeoxycholic acid levels and lower deoxycholic and lithocholic acid levels. Second, the score was associated with greater rice intake and lower Western sweets, pork, beef, and egg intake, and higher values were associated with lower deoxycholic and lithocholic acid levels. These relationships remained after adjusting for intestinal microbiota and defecation status variables.
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spelling doaj-art-e2201001c22f4d2b84178a0fb4a1e8e82025-01-19T12:17:46ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-025-86273-8High leafy and root vegetables and high rice dietary patterns were associated with primary and secondary bile acid levels in the fecesYosuke Saito0Toyoaki Sagae1Department of Clinical Nutrition, Faculty of Health and Wellness Sciences, Hiroshima International UniversityDepartment of Health and Nutrition, Yamagata Prefectural Yonezawa University of Nutrition SciencesAbstract Colorectal cancer has the second highest mortality among cancer sites worldwide, with increasing morbidity, high recurrence rates, and even poorer postoperative quality of life. Therefore, preventive strategies for colorectal cancer should be established. This study aimed to cross-sectionally explore dietary patterns affecting the intestinal metabolism of bile acids (BAs), a risk factor for colorectal cancer, in young Japanese women. We collected fecal samples for intestinal microbiota and BA analysis. We used the Bristol scale to determine 1-week defecation status. Moreover, the brief-type self-administered diet history questionnaire was used for habitual dietary intake status. Reduced-rank regression analysis revealed dietary patterns related to fecal BA levels. The relationship between dietary patterns and fecal BA levels was adjusted for defecation status and intestinal microbiota variables using analysis of covariance. Reduced-rank regression analysis generated two dietary pattern scores related to fecal BA levels. First, the score was associated with a greater intake of leafy and root vegetables, and higher values were associated with greater fecal cholic and chenodeoxycholic acid levels and lower deoxycholic and lithocholic acid levels. Second, the score was associated with greater rice intake and lower Western sweets, pork, beef, and egg intake, and higher values were associated with lower deoxycholic and lithocholic acid levels. These relationships remained after adjusting for intestinal microbiota and defecation status variables.https://doi.org/10.1038/s41598-025-86273-8Colorectal cancer preventionFecal bile acidsDietary patternsReduced-rank regressionRiceVegetable
spellingShingle Yosuke Saito
Toyoaki Sagae
High leafy and root vegetables and high rice dietary patterns were associated with primary and secondary bile acid levels in the feces
Scientific Reports
Colorectal cancer prevention
Fecal bile acids
Dietary patterns
Reduced-rank regression
Rice
Vegetable
title High leafy and root vegetables and high rice dietary patterns were associated with primary and secondary bile acid levels in the feces
title_full High leafy and root vegetables and high rice dietary patterns were associated with primary and secondary bile acid levels in the feces
title_fullStr High leafy and root vegetables and high rice dietary patterns were associated with primary and secondary bile acid levels in the feces
title_full_unstemmed High leafy and root vegetables and high rice dietary patterns were associated with primary and secondary bile acid levels in the feces
title_short High leafy and root vegetables and high rice dietary patterns were associated with primary and secondary bile acid levels in the feces
title_sort high leafy and root vegetables and high rice dietary patterns were associated with primary and secondary bile acid levels in the feces
topic Colorectal cancer prevention
Fecal bile acids
Dietary patterns
Reduced-rank regression
Rice
Vegetable
url https://doi.org/10.1038/s41598-025-86273-8
work_keys_str_mv AT yosukesaito highleafyandrootvegetablesandhighricedietarypatternswereassociatedwithprimaryandsecondarybileacidlevelsinthefeces
AT toyoakisagae highleafyandrootvegetablesandhighricedietarypatternswereassociatedwithprimaryandsecondarybileacidlevelsinthefeces