Colorectal cancer progression to metastasis is associated with dynamic genome-wide biphasic 5-hydroxymethylcytosine accumulation

Colorectal cancer progression to metastasis is associated with dynamic genome-wide biphasic 5-hydroxymethylcytosine accumulation

Abstract Background Colorectal cancer (CRC) progression from adenoma to adenocarcinoma is associated with global reduction in 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). DNA hypomethylation continues upon liver metastasis. Here we examine 5hmC changes upon progression to liver metasta...

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Main Authors: Ben Murcott, Floris Honig, Dominic Oliver Halliwell, Yuan Tian, James Lawrence Robson, Piotr Manasterski, Jennifer Pinnell, Thérèse Dix-Peek, Santiago Uribe-Lewis, Ashraf E. K. Ibrahim, Julia Sero, David Gurevich, Nikolas Nikolaou, Adele Murrell
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Biology
Subjects:
5-Hydroxymethylcytosine
Colorectal cancer progression to metastasis
Ten-eleven-translocation (TET)
Epigenetics
Zebrafish assay
Online Access:https://doi.org/10.1186/s12915-025-02205-y
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