Novel Strategies for the Improvement of Stem Cells’ Transplantation in Degenerative Retinal Diseases
Currently, there is no cure for the permanent vision loss caused by degenerative retinal diseases. One of the novel therapeutic strategies aims at the development of stem cells (SCs) based neuroprotective and regenerative medicine. The main sources of SCs for the treatment of retinal diseases are th...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/1236721 |
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| author | Simona Delia Nicoară Sergiu Șușman Oana Tudoran Otilia Bărbos Gabriela Cherecheș Simion Aștilean Monica Potara Olga Sorițău |
| author_facet | Simona Delia Nicoară Sergiu Șușman Oana Tudoran Otilia Bărbos Gabriela Cherecheș Simion Aștilean Monica Potara Olga Sorițău |
| author_sort | Simona Delia Nicoară |
| collection | DOAJ |
| description | Currently, there is no cure for the permanent vision loss caused by degenerative retinal diseases. One of the novel therapeutic strategies aims at the development of stem cells (SCs) based neuroprotective and regenerative medicine. The main sources of SCs for the treatment of retinal diseases are the embryo, the bone marrow, the region of neuronal genesis, and the eye. The success of transplantation depends on the origin of cells, the route of administration, the local microenvironment, and the proper combinative formula of growth factors. The feasibility of SCs based therapies for degenerative retinal diseases was proved in the preclinical setting. However, their translation into the clinical realm is limited by various factors: the immunogenicity of the cells, the stability of the cell phenotype, the predilection of SCs to form tumors in situ, the abnormality of the microenvironment, and the association of a synaptic rewiring. To improve SCs based therapies, nanotechnology offers a smart delivery system for biomolecules, such as growth factors for SCs implantation and differentiation into retinal progenitors. This review explores the main advances in the field of retinal transplantology and applications of nanotechnology in the treatment of retinal diseases, discusses the challenges, and suggests new therapeutic approaches in retinal transplantation. |
| format | Article |
| id | doaj-art-e214d6a6678246c785a9f7ad76780d53 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-e214d6a6678246c785a9f7ad76780d532025-02-03T01:00:51ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/12367211236721Novel Strategies for the Improvement of Stem Cells’ Transplantation in Degenerative Retinal DiseasesSimona Delia Nicoară0Sergiu Șușman1Oana Tudoran2Otilia Bărbos3Gabriela Cherecheș4Simion Aștilean5Monica Potara6Olga Sorițău7Department of Ophthalmology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, RomaniaDepartment of Histology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania“Ion Chiricuță” Institute of Oncology, Laboratory of Cell Biology and Radiobiology, 34-36 Ion Creangă Street, 400010 Cluj-Napoca, Romania“Ion Chiricuță” Institute of Oncology, Laboratory of Cell Biology and Radiobiology, 34-36 Ion Creangă Street, 400010 Cluj-Napoca, Romania“Ion Chiricuță” Institute of Oncology, Laboratory of Cell Biology and Radiobiology, 34-36 Ion Creangă Street, 400010 Cluj-Napoca, RomaniaNanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babeș-Bolyai University, 42 Treboniu Laurian Street, 400271 Cluj-Napoca, RomaniaNanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babeș-Bolyai University, 42 Treboniu Laurian Street, 400271 Cluj-Napoca, Romania“Ion Chiricuță” Institute of Oncology, Laboratory of Cell Biology and Radiobiology, 34-36 Ion Creangă Street, 400010 Cluj-Napoca, RomaniaCurrently, there is no cure for the permanent vision loss caused by degenerative retinal diseases. One of the novel therapeutic strategies aims at the development of stem cells (SCs) based neuroprotective and regenerative medicine. The main sources of SCs for the treatment of retinal diseases are the embryo, the bone marrow, the region of neuronal genesis, and the eye. The success of transplantation depends on the origin of cells, the route of administration, the local microenvironment, and the proper combinative formula of growth factors. The feasibility of SCs based therapies for degenerative retinal diseases was proved in the preclinical setting. However, their translation into the clinical realm is limited by various factors: the immunogenicity of the cells, the stability of the cell phenotype, the predilection of SCs to form tumors in situ, the abnormality of the microenvironment, and the association of a synaptic rewiring. To improve SCs based therapies, nanotechnology offers a smart delivery system for biomolecules, such as growth factors for SCs implantation and differentiation into retinal progenitors. This review explores the main advances in the field of retinal transplantology and applications of nanotechnology in the treatment of retinal diseases, discusses the challenges, and suggests new therapeutic approaches in retinal transplantation.http://dx.doi.org/10.1155/2016/1236721 |
| spellingShingle | Simona Delia Nicoară Sergiu Șușman Oana Tudoran Otilia Bărbos Gabriela Cherecheș Simion Aștilean Monica Potara Olga Sorițău Novel Strategies for the Improvement of Stem Cells’ Transplantation in Degenerative Retinal Diseases Stem Cells International |
| title | Novel Strategies for the Improvement of Stem Cells’ Transplantation in Degenerative Retinal Diseases |
| title_full | Novel Strategies for the Improvement of Stem Cells’ Transplantation in Degenerative Retinal Diseases |
| title_fullStr | Novel Strategies for the Improvement of Stem Cells’ Transplantation in Degenerative Retinal Diseases |
| title_full_unstemmed | Novel Strategies for the Improvement of Stem Cells’ Transplantation in Degenerative Retinal Diseases |
| title_short | Novel Strategies for the Improvement of Stem Cells’ Transplantation in Degenerative Retinal Diseases |
| title_sort | novel strategies for the improvement of stem cells transplantation in degenerative retinal diseases |
| url | http://dx.doi.org/10.1155/2016/1236721 |
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