Association of genetic risk of Alzheimer’s disease and cognitive function in two European populations

Association of genetic risk of Alzheimer’s disease and cognitive function in two European populations

Abstract Although there is some evidence of an association between Alzheimer’s disease polygenic risk score (AD PRS) and cognitive function, limited validations have been performed in large populations. We investigated the relationship between AD PRS and cognitive function in the UK Biobank in over...

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Bibliographic Details
Main Authors: Biqi Wang, Lori B. Chibnik, Seung Hoan Choi, Deborah Blacker, Anita L. DeStefano, Honghuang Lin
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Alzheimer’s disease
Polygenic risk score
Cognitive test
Cohort
Online Access:https://doi.org/10.1038/s41598-025-90277-9
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