Innovative Atherosclerosis Models: Advancing Pathophysiology and Translational Research
Atherosclerosis (AS) is a chronic inflammatory condition influenced by glucose and lipid disorders, oxidative stress, and thrombosis, reflecting the complexity of its pathological process. The development of accurate experimental models that simulate human AS is essential for understanding its initi...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2025-01-01
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| Series: | Research |
| Online Access: | https://spj.science.org/doi/10.34133/research.0617 |
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| author | Huiting Jiang Yukun Liao Mengliang Zhu Luksika Jiramonai Hongyun Wu Yixin Zhong Zulong Xie Xing-Jie Liang |
| author_facet | Huiting Jiang Yukun Liao Mengliang Zhu Luksika Jiramonai Hongyun Wu Yixin Zhong Zulong Xie Xing-Jie Liang |
| author_sort | Huiting Jiang |
| collection | DOAJ |
| description | Atherosclerosis (AS) is a chronic inflammatory condition influenced by glucose and lipid disorders, oxidative stress, and thrombosis, reflecting the complexity of its pathological process. The development of accurate experimental models that simulate human AS is essential for understanding its initiation and progression. This review summarizes the current AS research models and analyzes their specific application scenarios. We discuss tissue-engineered blood vessels (TEBVs) and vessels-on-a-chip (VoCs), which leverage tissue engineering and precise microenvironmental control to construct in vitro models that closely resemble the structure and function of human AS. Isolated vessel segments from live animals provide a valuable tool for investigating human AS due to their physiological similarity, controllability, and reproducibility. The review further outlines the construction of AS animal models through high-fat diets and gene-editing techniques, highlighting how immune-inflammatory responses, mechanical arterial injury, and hemodynamic changes accelerate model development. This comprehensive analysis highlights the potential of AS models to revolutionize theranostic applications in clinical translational research, paving the way for more personalized and effective treatments for AS in the near future. |
| format | Article |
| id | doaj-art-e20df56678144bf1b633d0f6210727e5 |
| institution | DOAJ |
| issn | 2639-5274 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Research |
| spelling | doaj-art-e20df56678144bf1b633d0f6210727e52025-08-20T03:12:20ZengAmerican Association for the Advancement of Science (AAAS)Research2639-52742025-01-01810.34133/research.0617Innovative Atherosclerosis Models: Advancing Pathophysiology and Translational ResearchHuiting Jiang0Yukun Liao1Mengliang Zhu2Luksika Jiramonai3Hongyun Wu4Yixin Zhong5Zulong Xie6Xing-Jie Liang7Department of Cardiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.Department of Nuclear, Affiliated People’s Hospital of Chongqing University, Chongqing 401121, China.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China.Department of Radiology, Second Affiliated Hospital of Chongqing Medical, Chongqing 400010, China.Department of Radiology, Second Affiliated Hospital of Chongqing Medical, Chongqing 400010, China.Department of Cardiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China.Atherosclerosis (AS) is a chronic inflammatory condition influenced by glucose and lipid disorders, oxidative stress, and thrombosis, reflecting the complexity of its pathological process. The development of accurate experimental models that simulate human AS is essential for understanding its initiation and progression. This review summarizes the current AS research models and analyzes their specific application scenarios. We discuss tissue-engineered blood vessels (TEBVs) and vessels-on-a-chip (VoCs), which leverage tissue engineering and precise microenvironmental control to construct in vitro models that closely resemble the structure and function of human AS. Isolated vessel segments from live animals provide a valuable tool for investigating human AS due to their physiological similarity, controllability, and reproducibility. The review further outlines the construction of AS animal models through high-fat diets and gene-editing techniques, highlighting how immune-inflammatory responses, mechanical arterial injury, and hemodynamic changes accelerate model development. This comprehensive analysis highlights the potential of AS models to revolutionize theranostic applications in clinical translational research, paving the way for more personalized and effective treatments for AS in the near future.https://spj.science.org/doi/10.34133/research.0617 |
| spellingShingle | Huiting Jiang Yukun Liao Mengliang Zhu Luksika Jiramonai Hongyun Wu Yixin Zhong Zulong Xie Xing-Jie Liang Innovative Atherosclerosis Models: Advancing Pathophysiology and Translational Research Research |
| title | Innovative Atherosclerosis Models: Advancing Pathophysiology and Translational Research |
| title_full | Innovative Atherosclerosis Models: Advancing Pathophysiology and Translational Research |
| title_fullStr | Innovative Atherosclerosis Models: Advancing Pathophysiology and Translational Research |
| title_full_unstemmed | Innovative Atherosclerosis Models: Advancing Pathophysiology and Translational Research |
| title_short | Innovative Atherosclerosis Models: Advancing Pathophysiology and Translational Research |
| title_sort | innovative atherosclerosis models advancing pathophysiology and translational research |
| url | https://spj.science.org/doi/10.34133/research.0617 |
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