MIR-155 as a potential biomarker for disease severity in st-segment elevation myocardial infarction: insights from a university-affiliated cardiovascular center
Background: MiR-155 plays a role in inflammatory pathways and cardiovascular diseases, though its relationship with inflammation, atherosclerosis, and outcomes in ST-elevation myocardial infarction (STEMI) is not well established. Objective: To investigate associations between miR-155 levels, inflam...
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2025-01-01
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| Series: | Revista de Investigación Clínica |
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| author | Ailyn Morales-Rentería Amina Ruiz-Santos Luis M. Amezcua-Castillo Jazmín A. Guerra-López Kietseé A. Díaz-Domínguez José L. Sánchez-Gloria Héctor Gonzalez-Pacheco Luis M. Amezcua-Guerra |
| author_facet | Ailyn Morales-Rentería Amina Ruiz-Santos Luis M. Amezcua-Castillo Jazmín A. Guerra-López Kietseé A. Díaz-Domínguez José L. Sánchez-Gloria Héctor Gonzalez-Pacheco Luis M. Amezcua-Guerra |
| author_sort | Ailyn Morales-Rentería |
| collection | DOAJ |
| description | Background: MiR-155 plays a role in inflammatory pathways and cardiovascular diseases, though its relationship with inflammation, atherosclerosis, and outcomes in ST-elevation myocardial infarction (STEMI) is not well established. Objective: To investigate associations between miR-155 levels, inflammation, atherosclerotic burden, and major adverse cardiovascular events (MACE) in STEMI patients. Methods: Sixty-nine STEMI patients and 16 healthy controls were recruited from a specialized university-affiliated cardiovascular center. MiR-155 expression and serum interleukin (IL)-1β, IL-6, and tumor necrosis factor levels were measured. Patients were grouped into tertiles based on miR-155 expression. Clinical data, atherosclerotic burden (through cardiac catheterization), and in-hospital MACE were recorded. Results: MiR-155 levels were significantly lower in STEMI patients compared to controls (median 54.2, vs. 152.8 arbitrary units; p = 0.003). Higher miR-155 tertiles were associated with a greater prevalence of three-vessel occlusion (34% vs. 13% vs. 4%; p = 0.007) and increased incidence of pulmonary edema (13% vs. 0% vs. 0%; p = 0.030). No significant correlation was found between miR-155 and inflammatory or myocardial markers. Conclusion: Dysregulated miR-155 expression in STEMI patients may influence disease severity and MACE risk, independent of inflammation or myocardial damage markers. (REV INVEST CLIN. 2025;77(1):6-12)
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| format | Article |
| id | doaj-art-e20a5d03da66478d93805da2cabe02b3 |
| institution | DOAJ |
| issn | 0034-8376 2564-8896 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Permanyer |
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| series | Revista de Investigación Clínica |
| spelling | doaj-art-e20a5d03da66478d93805da2cabe02b32025-08-20T02:58:18ZengPermanyerRevista de Investigación Clínica0034-83762564-88962025-01-0177110.24875/RIC.24000189MIR-155 as a potential biomarker for disease severity in st-segment elevation myocardial infarction: insights from a university-affiliated cardiovascular centerAilyn Morales-Rentería0Amina Ruiz-Santos1Luis M. Amezcua-Castillo2Jazmín A. Guerra-López3Kietseé A. Díaz-Domínguez4José L. Sánchez-Gloria5Héctor Gonzalez-Pacheco6Luis M. Amezcua-Guerra7School of Medicine, Universidad Autónoma Metropolitana (UAM)-Xochimilco, Mexico City, MexicoSchool of Medicine, Universidad Autónoma Metropolitana (UAM)-Xochimilco, Mexico City, MexicoCoronary Care Unit, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Internal Medicine, Division of Nephrology, Rush University Medical Center, Chicago, IL, USACoronary Care Unit, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico; Department of Health Care, UAM-Xochimilco, Mexico City, MexicoBackground: MiR-155 plays a role in inflammatory pathways and cardiovascular diseases, though its relationship with inflammation, atherosclerosis, and outcomes in ST-elevation myocardial infarction (STEMI) is not well established. Objective: To investigate associations between miR-155 levels, inflammation, atherosclerotic burden, and major adverse cardiovascular events (MACE) in STEMI patients. Methods: Sixty-nine STEMI patients and 16 healthy controls were recruited from a specialized university-affiliated cardiovascular center. MiR-155 expression and serum interleukin (IL)-1β, IL-6, and tumor necrosis factor levels were measured. Patients were grouped into tertiles based on miR-155 expression. Clinical data, atherosclerotic burden (through cardiac catheterization), and in-hospital MACE were recorded. Results: MiR-155 levels were significantly lower in STEMI patients compared to controls (median 54.2, vs. 152.8 arbitrary units; p = 0.003). Higher miR-155 tertiles were associated with a greater prevalence of three-vessel occlusion (34% vs. 13% vs. 4%; p = 0.007) and increased incidence of pulmonary edema (13% vs. 0% vs. 0%; p = 0.030). No significant correlation was found between miR-155 and inflammatory or myocardial markers. Conclusion: Dysregulated miR-155 expression in STEMI patients may influence disease severity and MACE risk, independent of inflammation or myocardial damage markers. (REV INVEST CLIN. 2025;77(1):6-12) https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=521MiR-155. Myocardial infarction. Inflammation. |
| spellingShingle | Ailyn Morales-Rentería Amina Ruiz-Santos Luis M. Amezcua-Castillo Jazmín A. Guerra-López Kietseé A. Díaz-Domínguez José L. Sánchez-Gloria Héctor Gonzalez-Pacheco Luis M. Amezcua-Guerra MIR-155 as a potential biomarker for disease severity in st-segment elevation myocardial infarction: insights from a university-affiliated cardiovascular center Revista de Investigación Clínica MiR-155. Myocardial infarction. Inflammation. |
| title | MIR-155 as a potential biomarker for disease severity in st-segment elevation myocardial infarction: insights from a university-affiliated cardiovascular center |
| title_full | MIR-155 as a potential biomarker for disease severity in st-segment elevation myocardial infarction: insights from a university-affiliated cardiovascular center |
| title_fullStr | MIR-155 as a potential biomarker for disease severity in st-segment elevation myocardial infarction: insights from a university-affiliated cardiovascular center |
| title_full_unstemmed | MIR-155 as a potential biomarker for disease severity in st-segment elevation myocardial infarction: insights from a university-affiliated cardiovascular center |
| title_short | MIR-155 as a potential biomarker for disease severity in st-segment elevation myocardial infarction: insights from a university-affiliated cardiovascular center |
| title_sort | mir 155 as a potential biomarker for disease severity in st segment elevation myocardial infarction insights from a university affiliated cardiovascular center |
| topic | MiR-155. Myocardial infarction. Inflammation. |
| url | https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=521 |
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