DOWNSTREAM PROCESS OF BIOPHARMACEUTICALS
The development of the biopharmaceuticals begins with the development of effective producers. But the more complex protein and its producer, the greater the amount of impurities is synthesized or accumulated during the upstream process. Among them are as follows: bacterial endotoxins, viruses, host...
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/294 |
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| _version_ | 1849696197864849408 |
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| author | D. A. Gusarov |
| author_facet | D. A. Gusarov |
| author_sort | D. A. Gusarov |
| collection | DOAJ |
| description | The development of the biopharmaceuticals begins with the development of effective producers. But the more complex protein and its producer, the greater the amount of impurities is synthesized or accumulated during the upstream process. Among them are as follows: bacterial endotoxins, viruses, host cell proteins, related impurities, aggregates and high molecular weight admixtures etc. This article describes approaches to the downstream process purification of biopharmaceutical proteins. We discuss the main chromatography and non-chromatographical methods. |
| format | Article |
| id | doaj-art-e209e0bed88642cd9d9619b57f44bda7 |
| institution | DOAJ |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-e209e0bed88642cd9d9619b57f44bda72025-08-20T03:19:32ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-01038899294DOWNSTREAM PROCESS OF BIOPHARMACEUTICALSD. A. Gusarov0R&D and Pilo Plant Biotechnological Platform «ExpertBIOTECH»The development of the biopharmaceuticals begins with the development of effective producers. But the more complex protein and its producer, the greater the amount of impurities is synthesized or accumulated during the upstream process. Among them are as follows: bacterial endotoxins, viruses, host cell proteins, related impurities, aggregates and high molecular weight admixtures etc. This article describes approaches to the downstream process purification of biopharmaceutical proteins. We discuss the main chromatography and non-chromatographical methods.https://www.pharmjournal.ru/jour/article/view/294downstream processpurificationimpurities |
| spellingShingle | D. A. Gusarov DOWNSTREAM PROCESS OF BIOPHARMACEUTICALS Разработка и регистрация лекарственных средств downstream process purification impurities |
| title | DOWNSTREAM PROCESS OF BIOPHARMACEUTICALS |
| title_full | DOWNSTREAM PROCESS OF BIOPHARMACEUTICALS |
| title_fullStr | DOWNSTREAM PROCESS OF BIOPHARMACEUTICALS |
| title_full_unstemmed | DOWNSTREAM PROCESS OF BIOPHARMACEUTICALS |
| title_short | DOWNSTREAM PROCESS OF BIOPHARMACEUTICALS |
| title_sort | downstream process of biopharmaceuticals |
| topic | downstream process purification impurities |
| url | https://www.pharmjournal.ru/jour/article/view/294 |
| work_keys_str_mv | AT dagusarov downstreamprocessofbiopharmaceuticals |