Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis
The effect of hyperbaric oxygen treatment (HBOT) was examined using MSG mice, which are an animal model of obesity, hyperlipidemia, diabetes, and nonalcoholic fatty liver disease. Nineteen MSG male mice were divided into HBOT treated and control groups at 12 weeks of ages. The HBOT group was treated...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2011/380236 |
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| author | Koichi Tsuneyama Yen-Chen Chen Makoto Fujimoto Yoshiyuki Sasaki Wataru Suzuki Tsutomu Shimada Seiichi Iizuka Mitsunobu Nagata Masaki Aburada Shao-Yuan Chen |
| author_facet | Koichi Tsuneyama Yen-Chen Chen Makoto Fujimoto Yoshiyuki Sasaki Wataru Suzuki Tsutomu Shimada Seiichi Iizuka Mitsunobu Nagata Masaki Aburada Shao-Yuan Chen |
| author_sort | Koichi Tsuneyama |
| collection | DOAJ |
| description | The effect of hyperbaric oxygen treatment (HBOT) was examined using MSG mice, which are an animal model of obesity, hyperlipidemia, diabetes, and nonalcoholic fatty liver disease. Nineteen MSG male mice were divided into HBOT treated and control groups at 12 weeks of ages. The HBOT group was treated with hyperbaric oxygen from 12 to 14 weeks (first phase) and then from 16 to 18 weeks (second phase). Interestingly, the body weight of the HBOT group was significantly lower (P<0.01) than that of the control group. In contrast, the serum lipid level did not show significant changes between the two groups. As for the effects of increasing oxidative stress, the liver histology of the HBOT group showed severer cellular damage and aberrant TNF-α expression. HBOT has the advantage of improving obesity in patients with metabolic syndrome, but the fault of causing organ damage by increasing oxidative stress. |
| format | Article |
| id | doaj-art-e1ff57c336f54aa6a9ec47a29b9f2e48 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e1ff57c336f54aa6a9ec47a29b9f2e482025-02-03T06:00:59ZengWileyThe Scientific World Journal1537-744X2011-01-01112124213510.1100/2011/380236380236Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and SteatohepatitisKoichi Tsuneyama0Yen-Chen Chen1Makoto Fujimoto2Yoshiyuki Sasaki3Wataru Suzuki4Tsutomu Shimada5Seiichi Iizuka6Mitsunobu Nagata7Masaki Aburada8Shao-Yuan Chen9Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanDepartment of Microbiology and Immunology, National Defense Medical Center, Taipei, TaiwanDepartment of Japanese Oriental Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanInstitute for Animal Reproduction, 1103 Fukaya, Kasumigaura-shi, Ibaraki 300-0134, JapanFaculty of Pharmacy, Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo 202-8585, JapanFaculty of Pharmacy, Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo 202-8585, JapanFaculty of Pharmacy, Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo 202-8585, JapanFaculty of Pharmacy, Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo 202-8585, JapanFaculty of Pharmacy, Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo 202-8585, JapanSchool of Medicine, Fu Jen Catholic University, New Taipei City, TaiwanThe effect of hyperbaric oxygen treatment (HBOT) was examined using MSG mice, which are an animal model of obesity, hyperlipidemia, diabetes, and nonalcoholic fatty liver disease. Nineteen MSG male mice were divided into HBOT treated and control groups at 12 weeks of ages. The HBOT group was treated with hyperbaric oxygen from 12 to 14 weeks (first phase) and then from 16 to 18 weeks (second phase). Interestingly, the body weight of the HBOT group was significantly lower (P<0.01) than that of the control group. In contrast, the serum lipid level did not show significant changes between the two groups. As for the effects of increasing oxidative stress, the liver histology of the HBOT group showed severer cellular damage and aberrant TNF-α expression. HBOT has the advantage of improving obesity in patients with metabolic syndrome, but the fault of causing organ damage by increasing oxidative stress.http://dx.doi.org/10.1100/2011/380236 |
| spellingShingle | Koichi Tsuneyama Yen-Chen Chen Makoto Fujimoto Yoshiyuki Sasaki Wataru Suzuki Tsutomu Shimada Seiichi Iizuka Mitsunobu Nagata Masaki Aburada Shao-Yuan Chen Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis The Scientific World Journal |
| title | Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis |
| title_full | Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis |
| title_fullStr | Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis |
| title_full_unstemmed | Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis |
| title_short | Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis |
| title_sort | advantages and disadvantages of hyperbaric oxygen treatment in mice with obesity hyperlipidemia and steatohepatitis |
| url | http://dx.doi.org/10.1100/2011/380236 |
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