Construction of a ferroptosis and hypoxia-related gene signature in cervical cancer to assess tumour immune microenvironment and predict prognosis
Background This study aimed to investigate the potential role of ferroptosis/hypoxia-related genes in cervical cancer to improve early management and treatment of cervical cancer.Methods All data were downloaded from public databases. Ferroptosis/hypoxia-related genes associated with cervical cancer...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Obstetrics and Gynaecology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/01443615.2024.2321323 |
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| _version_ | 1841553187047211008 |
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| author | Haiyan Wu Yayun Fan Yuanyuan Bao Qing Zhou Lei Xu Yao Xu |
| author_facet | Haiyan Wu Yayun Fan Yuanyuan Bao Qing Zhou Lei Xu Yao Xu |
| author_sort | Haiyan Wu |
| collection | DOAJ |
| description | Background This study aimed to investigate the potential role of ferroptosis/hypoxia-related genes in cervical cancer to improve early management and treatment of cervical cancer.Methods All data were downloaded from public databases. Ferroptosis/hypoxia-related genes associated with cervical cancer prognosis were selected to construct a risk score model. The relationship between risk score and clinical features, immune microenvironment and prognosis were analysed.Results Risk score model was constructed based on eight signature genes. Drug prediction analysis showed that bevacizumab and cisplatin were related to vascular endothelial growth factor A. Risk score, as an independent prognostic factor of cervical cancer, had a good survival prediction effect. The two groups differed significantly in degree of immune cell infiltration, gene expression, tumour mutation burden and somatic variation.Conclusions We developed a novel prognostic gene signature combining ferroptosis/hypoxia-related genes, which provides new ideas for individual treatment of cervical cancer. |
| format | Article |
| id | doaj-art-e1fe8a87ccf54dddb4f51c9fb79bd119 |
| institution | Kabale University |
| issn | 0144-3615 1364-6893 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Obstetrics and Gynaecology |
| spelling | doaj-art-e1fe8a87ccf54dddb4f51c9fb79bd1192025-01-09T12:13:17ZengTaylor & Francis GroupJournal of Obstetrics and Gynaecology0144-36151364-68932024-12-0144110.1080/01443615.2024.2321323Construction of a ferroptosis and hypoxia-related gene signature in cervical cancer to assess tumour immune microenvironment and predict prognosisHaiyan Wu0Yayun Fan1Yuanyuan Bao2Qing Zhou3Lei Xu4Yao Xu5Department of Gynecology, Chengdu Second People’s Hospital, Chengdu, ChinaDepartment of Gynecology, Chengdu Second People’s Hospital, Chengdu, ChinaDepartment of Gynecology, Chengdu Second People’s Hospital, Chengdu, ChinaDepartment of Gynecology, Chengdu Second People’s Hospital, Chengdu, ChinaDepartment of Gynecology, The First Affiliated Hospital of Chengdu Medical College, Chengdu City, PR ChinaDepartment of Gynecology, The First Affiliated Hospital of Chengdu Medical College, Chengdu City, PR ChinaBackground This study aimed to investigate the potential role of ferroptosis/hypoxia-related genes in cervical cancer to improve early management and treatment of cervical cancer.Methods All data were downloaded from public databases. Ferroptosis/hypoxia-related genes associated with cervical cancer prognosis were selected to construct a risk score model. The relationship between risk score and clinical features, immune microenvironment and prognosis were analysed.Results Risk score model was constructed based on eight signature genes. Drug prediction analysis showed that bevacizumab and cisplatin were related to vascular endothelial growth factor A. Risk score, as an independent prognostic factor of cervical cancer, had a good survival prediction effect. The two groups differed significantly in degree of immune cell infiltration, gene expression, tumour mutation burden and somatic variation.Conclusions We developed a novel prognostic gene signature combining ferroptosis/hypoxia-related genes, which provides new ideas for individual treatment of cervical cancer.https://www.tandfonline.com/doi/10.1080/01443615.2024.2321323Cervical cancerferroptosishypoxiaprognosissignature gene |
| spellingShingle | Haiyan Wu Yayun Fan Yuanyuan Bao Qing Zhou Lei Xu Yao Xu Construction of a ferroptosis and hypoxia-related gene signature in cervical cancer to assess tumour immune microenvironment and predict prognosis Journal of Obstetrics and Gynaecology Cervical cancer ferroptosis hypoxia prognosis signature gene |
| title | Construction of a ferroptosis and hypoxia-related gene signature in cervical cancer to assess tumour immune microenvironment and predict prognosis |
| title_full | Construction of a ferroptosis and hypoxia-related gene signature in cervical cancer to assess tumour immune microenvironment and predict prognosis |
| title_fullStr | Construction of a ferroptosis and hypoxia-related gene signature in cervical cancer to assess tumour immune microenvironment and predict prognosis |
| title_full_unstemmed | Construction of a ferroptosis and hypoxia-related gene signature in cervical cancer to assess tumour immune microenvironment and predict prognosis |
| title_short | Construction of a ferroptosis and hypoxia-related gene signature in cervical cancer to assess tumour immune microenvironment and predict prognosis |
| title_sort | construction of a ferroptosis and hypoxia related gene signature in cervical cancer to assess tumour immune microenvironment and predict prognosis |
| topic | Cervical cancer ferroptosis hypoxia prognosis signature gene |
| url | https://www.tandfonline.com/doi/10.1080/01443615.2024.2321323 |
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