Nuclear p62/SQSTM1 facilitates ubiquitin-independent proteasomal degradation of BMAL1.

Nuclear p62/SQSTM1 facilitates ubiquitin-independent proteasomal degradation of BMAL1.

Brain and muscle arnt-like protein 1(BMAL1) is a critical regulator of circadian rhythm. Although transcriptional regulation of BMAL1 has been extensively studied, the mechanisms governing the stability of BMAL1 at the protein level remain unclear. p62/SQSTM1 is a crucial factor in proteostasis regu...

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Bibliographic Details
Main Authors: Chenliang Zhang, Quanyou Wu, Huan Zhang, Ruichen Liu, Liping Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011794
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