Circular RNA circIGF1R controls cardiac fibroblast proliferation through regulation of carbohydrate metabolism

Circular RNA circIGF1R controls cardiac fibroblast proliferation through regulation of carbohydrate metabolism

Abstract Excessive fibroblast proliferation and metabolic reprogramming are hallmarks of pathological cardiac remodeling, contributing significantly to impaired cardiac function. This study investigates the role of circular RNAs (circRNAs) in fibroblast metabolic reprogramming, an unexplored area wi...

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Bibliographic Details
Main Authors: Arne Schmidt, Kevin Schmidt, Sonja Groß, Dongchao Lu, Ke Xiao, Dimyana Neufeldt, Sarah Cushman, Nele Lehmann, Sabrina Thum, Angelika Pfanne, Annette Just, Andreas Pich, Alexander Heinz, Karsten Hiller, Hannah Jill Hunkler, Wilson Lek Wen Tan, Roger Foo, Christian Bär, Thomas Thum, Mira Jung
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Circular RNA
Cardiac fibrosis
Cardiac fibroblast
Cardiac metabolism
Glycolysis
Proliferation
Online Access:https://doi.org/10.1038/s41598-025-07167-3
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