Sex-specific associations of fat and lean indices with vertebral fractures
Abstract The relationship between body composition and fracture sites is complex. Previous studies have reported that a site-dependent relationship between body mass index (BMI) and fractures in postmenopausal women and older men. This study aimed to investigate sex-specific associations of fat and...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-07552-y |
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| author | Yen-Huai Lin Michael Mu Huo Teng |
| author_facet | Yen-Huai Lin Michael Mu Huo Teng |
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| description | Abstract The relationship between body composition and fracture sites is complex. Previous studies have reported that a site-dependent relationship between body mass index (BMI) and fractures in postmenopausal women and older men. This study aimed to investigate sex-specific associations of fat and lean indices with vertebral fractures. This cross-sectional study included 1,479 participants, with body composition assessed using dual-energy X-ray absorptiometry. Fat indices included BMI, body fat percentage, and waist circumference, whereas the lean index was represented by appendicular lean mass (ALM)/height². Prevalent vertebral fractures were identified through radiographic confirmation. When both fat and lean indices simultaneously were considered, BMI (odds ratio [OR], 1.15; 95% confidence interval [CI] 1.08–1.22), body fat percentage (OR, 1.06; 95% CI 1.02–1.10), and waist circumference (OR, 1.06; 95% CI, 1.03–1.08) were significantly associated with vertebral fractures in postmenopausal women, whereas ALM/height² did not show such an association. In contrast, for men aged ≥ 50 years, ALM/height² was significantly associated with vertebral fractures, whereas fat indices showed no such an association. Furthermore, a significant interaction between ALM/height² and sex was observed. Fat indices were predominantly associated with vertebral fractures in women, whereas the lean index was more strongly associated with vertebral fractures in men. These findings highlight a sex-specific association between body composition and vertebral fractures. |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-07-01 |
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| spelling | doaj-art-e1f901442b41465eaf8dc82f6f3b10d02025-08-20T03:38:15ZengNature PortfolioScientific Reports2045-23222025-07-011511610.1038/s41598-025-07552-ySex-specific associations of fat and lean indices with vertebral fracturesYen-Huai Lin0Michael Mu Huo Teng1Department of Medical Imaging, Cheng Hsin General HospitalDepartment of Medical Imaging, Cheng Hsin General HospitalAbstract The relationship between body composition and fracture sites is complex. Previous studies have reported that a site-dependent relationship between body mass index (BMI) and fractures in postmenopausal women and older men. This study aimed to investigate sex-specific associations of fat and lean indices with vertebral fractures. This cross-sectional study included 1,479 participants, with body composition assessed using dual-energy X-ray absorptiometry. Fat indices included BMI, body fat percentage, and waist circumference, whereas the lean index was represented by appendicular lean mass (ALM)/height². Prevalent vertebral fractures were identified through radiographic confirmation. When both fat and lean indices simultaneously were considered, BMI (odds ratio [OR], 1.15; 95% confidence interval [CI] 1.08–1.22), body fat percentage (OR, 1.06; 95% CI 1.02–1.10), and waist circumference (OR, 1.06; 95% CI, 1.03–1.08) were significantly associated with vertebral fractures in postmenopausal women, whereas ALM/height² did not show such an association. In contrast, for men aged ≥ 50 years, ALM/height² was significantly associated with vertebral fractures, whereas fat indices showed no such an association. Furthermore, a significant interaction between ALM/height² and sex was observed. Fat indices were predominantly associated with vertebral fractures in women, whereas the lean index was more strongly associated with vertebral fractures in men. These findings highlight a sex-specific association between body composition and vertebral fractures.https://doi.org/10.1038/s41598-025-07552-yAppendicular lean massBody fat percentageBody mass indexSexVertebral fracturesWaist circumference |
| spellingShingle | Yen-Huai Lin Michael Mu Huo Teng Sex-specific associations of fat and lean indices with vertebral fractures Scientific Reports Appendicular lean mass Body fat percentage Body mass index Sex Vertebral fractures Waist circumference |
| title | Sex-specific associations of fat and lean indices with vertebral fractures |
| title_full | Sex-specific associations of fat and lean indices with vertebral fractures |
| title_fullStr | Sex-specific associations of fat and lean indices with vertebral fractures |
| title_full_unstemmed | Sex-specific associations of fat and lean indices with vertebral fractures |
| title_short | Sex-specific associations of fat and lean indices with vertebral fractures |
| title_sort | sex specific associations of fat and lean indices with vertebral fractures |
| topic | Appendicular lean mass Body fat percentage Body mass index Sex Vertebral fractures Waist circumference |
| url | https://doi.org/10.1038/s41598-025-07552-y |
| work_keys_str_mv | AT yenhuailin sexspecificassociationsoffatandleanindiceswithvertebralfractures AT michaelmuhuoteng sexspecificassociationsoffatandleanindiceswithvertebralfractures |