Antifungal resistance and clinical significance in small animals
Fungal diseases have risen in conjunction with the increasing number of immunosuppressive diseases in human and animal populations. Despite the introduction of new antifungal agents in recent years, the incidence of fungal infections continues to increase, and subsequently, the prevalence of resista...
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| Format: | Article |
| Language: | English |
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German Multidisciplinary Publishing Center (GMPC)
2022-01-01
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| Series: | German Journal of Veterinary Research |
| Online Access: | https://doi.org/10.51585/gjvr.2022.2.0034 |
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| author | Yasemin Kaya Banu Dokuzeylül Utku Bakırel Mehmet Or |
| author_facet | Yasemin Kaya Banu Dokuzeylül Utku Bakırel Mehmet Or |
| author_sort | Yasemin Kaya |
| collection | DOAJ |
| description | Fungal diseases have risen in conjunction with the increasing number of immunosuppressive diseases in human and animal populations. Despite the introduction of new antifungal agents in recent years, the incidence of fungal infections continues to increase, and subsequently, the prevalence of resistance to these drugs is remarkably increased, posing significant health concerns. While antifungal drug resistance is of great importance in human medicine, especially against Candida spp., there are few studies about antifungal resistance in veterinary medicine. Indeed, several fungal infections include blastomycosis, candidiasis, coccidiomycosis, cryptococcosis, dermatophytosis, histoplasmosis, and Malassezia spp. infections have been reported in dogs and cats. Several antifungal drugs such as polyenes, azoles, pyrimidines, echinocandins, and allylamines have been encountered in feline and canine medicine. However, the desired success could not be obtained from the treatments applied in various cases in recent years due to antifungal resistance. This review aimed to emphasize the main common fungal infections in dogs and cats and the role of developing resistance against antifungal agents on treatment failures. Additionally, we discussed the mode of action of antifungal drugs, mechanisms of resistance, and factors that contribute to the emergence of resistance. In this context, monitoring of antifungal resistance in veterinary clinics and animal facilities by veterinarians and other animal health authorities is recommended. |
| format | Article |
| id | doaj-art-e1f80582f0724c4abbfa8acd96e5f45b |
| institution | DOAJ |
| issn | 2703-1322 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | German Multidisciplinary Publishing Center (GMPC) |
| record_format | Article |
| series | German Journal of Veterinary Research |
| spelling | doaj-art-e1f80582f0724c4abbfa8acd96e5f45b2025-08-20T03:20:58ZengGerman Multidisciplinary Publishing Center (GMPC)German Journal of Veterinary Research2703-13222022-01-01283810.51585/gjvr.2022.2.0034Antifungal resistance and clinical significance in small animalsYasemin KayaBanu DokuzeylülUtku BakırelMehmet OrFungal diseases have risen in conjunction with the increasing number of immunosuppressive diseases in human and animal populations. Despite the introduction of new antifungal agents in recent years, the incidence of fungal infections continues to increase, and subsequently, the prevalence of resistance to these drugs is remarkably increased, posing significant health concerns. While antifungal drug resistance is of great importance in human medicine, especially against Candida spp., there are few studies about antifungal resistance in veterinary medicine. Indeed, several fungal infections include blastomycosis, candidiasis, coccidiomycosis, cryptococcosis, dermatophytosis, histoplasmosis, and Malassezia spp. infections have been reported in dogs and cats. Several antifungal drugs such as polyenes, azoles, pyrimidines, echinocandins, and allylamines have been encountered in feline and canine medicine. However, the desired success could not be obtained from the treatments applied in various cases in recent years due to antifungal resistance. This review aimed to emphasize the main common fungal infections in dogs and cats and the role of developing resistance against antifungal agents on treatment failures. Additionally, we discussed the mode of action of antifungal drugs, mechanisms of resistance, and factors that contribute to the emergence of resistance. In this context, monitoring of antifungal resistance in veterinary clinics and animal facilities by veterinarians and other animal health authorities is recommended.https://doi.org/10.51585/gjvr.2022.2.0034 |
| spellingShingle | Yasemin Kaya Banu Dokuzeylül Utku Bakırel Mehmet Or Antifungal resistance and clinical significance in small animals German Journal of Veterinary Research |
| title | Antifungal resistance and clinical significance in small animals |
| title_full | Antifungal resistance and clinical significance in small animals |
| title_fullStr | Antifungal resistance and clinical significance in small animals |
| title_full_unstemmed | Antifungal resistance and clinical significance in small animals |
| title_short | Antifungal resistance and clinical significance in small animals |
| title_sort | antifungal resistance and clinical significance in small animals |
| url | https://doi.org/10.51585/gjvr.2022.2.0034 |
| work_keys_str_mv | AT yaseminkaya antifungalresistanceandclinicalsignificanceinsmallanimals AT banudokuzeylul antifungalresistanceandclinicalsignificanceinsmallanimals AT utkubakırel antifungalresistanceandclinicalsignificanceinsmallanimals AT mehmetor antifungalresistanceandclinicalsignificanceinsmallanimals |