Association between triglyceride-to-HDL-cholesterol ratio and risk of gestational diabetes mellitus in the first trimester: a retrospective cohort study
This retrospective cohort study examined the association between first-trimester triglyceride-to-HDL cholesterol (TG/HDL-C) ratio and gestational diabetes mellitus (GDM) risk among 2,356 pregnant women from Shanghai General Hospital between October 2019, and June 2021. Using logistic regression and...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Gynecological Endocrinology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09513590.2025.2528817 |
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| author | Hao-Yi Jia Peng-Yuan He Jin Zhang Meng-Jie Zhou Xian-Ming Xu |
| author_facet | Hao-Yi Jia Peng-Yuan He Jin Zhang Meng-Jie Zhou Xian-Ming Xu |
| author_sort | Hao-Yi Jia |
| collection | DOAJ |
| description | This retrospective cohort study examined the association between first-trimester triglyceride-to-HDL cholesterol (TG/HDL-C) ratio and gestational diabetes mellitus (GDM) risk among 2,356 pregnant women from Shanghai General Hospital between October 2019, and June 2021. Using logistic regression and restricted cubic spline models, we found the TG/HDL-C ratio was an independent GDM predictor (OR:1.37, 95%CI:1.16-1.62, p<0.001), persisting after adjustment (aOR:1.65, 95%CI:1.27-2.13, p<0.001). Nonlinear dose-response relationships were observed (p-interaction<0.05), with stronger associations in women >35 years (OR:1.60, 95%CI:1.12-2.28) and those with BMI≥25kg/m² (OR:1.78, 95%CI:1.25-2.54). First-trimester TG/HDL-C ratio elevation significantly increases GDM risk, suggesting its potential for early risk stratification and targeted prevention. |
| format | Article |
| id | doaj-art-e1f0de53543843bb977256bcfe24ef94 |
| institution | Kabale University |
| issn | 0951-3590 1473-0766 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gynecological Endocrinology |
| spelling | doaj-art-e1f0de53543843bb977256bcfe24ef942025-08-20T03:33:31ZengTaylor & Francis GroupGynecological Endocrinology0951-35901473-07662025-12-0141110.1080/09513590.2025.2528817Association between triglyceride-to-HDL-cholesterol ratio and risk of gestational diabetes mellitus in the first trimester: a retrospective cohort studyHao-Yi Jia0Peng-Yuan He1Jin Zhang2Meng-Jie Zhou3Xian-Ming Xu4Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaThis retrospective cohort study examined the association between first-trimester triglyceride-to-HDL cholesterol (TG/HDL-C) ratio and gestational diabetes mellitus (GDM) risk among 2,356 pregnant women from Shanghai General Hospital between October 2019, and June 2021. Using logistic regression and restricted cubic spline models, we found the TG/HDL-C ratio was an independent GDM predictor (OR:1.37, 95%CI:1.16-1.62, p<0.001), persisting after adjustment (aOR:1.65, 95%CI:1.27-2.13, p<0.001). Nonlinear dose-response relationships were observed (p-interaction<0.05), with stronger associations in women >35 years (OR:1.60, 95%CI:1.12-2.28) and those with BMI≥25kg/m² (OR:1.78, 95%CI:1.25-2.54). First-trimester TG/HDL-C ratio elevation significantly increases GDM risk, suggesting its potential for early risk stratification and targeted prevention.https://www.tandfonline.com/doi/10.1080/09513590.2025.2528817Gestational diabetes mellitusmetabolic disorderrisk factorsserum lipid profileTG/HDL-C ratio |
| spellingShingle | Hao-Yi Jia Peng-Yuan He Jin Zhang Meng-Jie Zhou Xian-Ming Xu Association between triglyceride-to-HDL-cholesterol ratio and risk of gestational diabetes mellitus in the first trimester: a retrospective cohort study Gynecological Endocrinology Gestational diabetes mellitus metabolic disorder risk factors serum lipid profile TG/HDL-C ratio |
| title | Association between triglyceride-to-HDL-cholesterol ratio and risk of gestational diabetes mellitus in the first trimester: a retrospective cohort study |
| title_full | Association between triglyceride-to-HDL-cholesterol ratio and risk of gestational diabetes mellitus in the first trimester: a retrospective cohort study |
| title_fullStr | Association between triglyceride-to-HDL-cholesterol ratio and risk of gestational diabetes mellitus in the first trimester: a retrospective cohort study |
| title_full_unstemmed | Association between triglyceride-to-HDL-cholesterol ratio and risk of gestational diabetes mellitus in the first trimester: a retrospective cohort study |
| title_short | Association between triglyceride-to-HDL-cholesterol ratio and risk of gestational diabetes mellitus in the first trimester: a retrospective cohort study |
| title_sort | association between triglyceride to hdl cholesterol ratio and risk of gestational diabetes mellitus in the first trimester a retrospective cohort study |
| topic | Gestational diabetes mellitus metabolic disorder risk factors serum lipid profile TG/HDL-C ratio |
| url | https://www.tandfonline.com/doi/10.1080/09513590.2025.2528817 |
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