Epidemiology and clinical course of COVID-19 in Shanghai, China
Background: Novel coronavirus pneumonia (COVID-19) is prevalent around the world. We aimed to describe epidemiological features and clinical course in Shanghai.Methods: We retrospectively analysed 325 cases admitted at Shanghai Public Health Clinical Center, between January 20 and February 29, 2020....
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2020.1787103 |
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| author | Yinzhong Shen Fang Zheng Danfeng Sun Yun Ling Jun Chen Feng Li Tao Li Zhiping Qian Yuyi Zhang Qingnian Xu Li Liu Qin Huang Fei Shan Lie Xu Jun Wu Zhaoqin Zhu Zhigang Song Shenyang Li Yuxin Shi Jianliang Zhang Xueyun Wu Joshua B. Mendelsohn Tongyu Zhu Hongzhou Lu |
| author_facet | Yinzhong Shen Fang Zheng Danfeng Sun Yun Ling Jun Chen Feng Li Tao Li Zhiping Qian Yuyi Zhang Qingnian Xu Li Liu Qin Huang Fei Shan Lie Xu Jun Wu Zhaoqin Zhu Zhigang Song Shenyang Li Yuxin Shi Jianliang Zhang Xueyun Wu Joshua B. Mendelsohn Tongyu Zhu Hongzhou Lu |
| author_sort | Yinzhong Shen |
| collection | DOAJ |
| description | Background: Novel coronavirus pneumonia (COVID-19) is prevalent around the world. We aimed to describe epidemiological features and clinical course in Shanghai.Methods: We retrospectively analysed 325 cases admitted at Shanghai Public Health Clinical Center, between January 20 and February 29, 2020.Results: 47.4% (154/325) had visited Wuhan within 2 weeks of illness onset. 57.2% occurred in 67 clusters; 40% were situated within 53 family clusters. 83.7% developed fever during the disease course. Median times from onset to first medical care, hospitalization and negative detection of nucleic acid by nasopharyngeal swab were 1, 4 and 8 days. Patients with mild disease using glucocorticoid tended to have longer viral shedding in blood and feces. At admission, 69.8% presented with lymphopenia and 38.8% had elevated D-dimers. Pneumonia was identified in 97.5% (314/322) of cases by chest CT scan. Severe-critical patients were 8% with a median time from onset to critical disease of 10.5 days. Half required oxygen therapy and 7.1% high-flow nasal oxygen. The case fatality rate was 0.92% with median time from onset to death of 16 days.Conclusion: COVID-19 cases in Shanghai were imported. Rapid identification, and effective control measures helped to contain the outbreak and prevent community transmission. |
| format | Article |
| id | doaj-art-e1ebc195ca694044a882d6559149ce32 |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-e1ebc195ca694044a882d6559149ce322025-08-20T02:26:30ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512020-01-01911537154510.1080/22221751.2020.1787103Epidemiology and clinical course of COVID-19 in Shanghai, ChinaYinzhong Shen0Fang Zheng1Danfeng Sun2Yun Ling3Jun Chen4Feng Li5Tao Li6Zhiping Qian7Yuyi Zhang8Qingnian Xu9Li Liu10Qin Huang11Fei Shan12Lie Xu13Jun Wu14Zhaoqin Zhu15Zhigang Song16Shenyang Li17Yuxin Shi18Jianliang Zhang19Xueyun Wu20Joshua B. Mendelsohn21Tongyu Zhu22Hongzhou Lu23Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Medical Affairs, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Medical Affairs, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Respiratory Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Tuberculosis, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Severe Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, ChinaDepartment of Severe Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, ChinaDepartment of Traditional Chinese Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Medical Affairs, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Medical Affairs, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaClinical Laboratory, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaP3 Laboratory, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaData Management Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Gastroenterology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaCollege of Health Professions, Pace University, New York, NY, USADepartment of Urology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaBackground: Novel coronavirus pneumonia (COVID-19) is prevalent around the world. We aimed to describe epidemiological features and clinical course in Shanghai.Methods: We retrospectively analysed 325 cases admitted at Shanghai Public Health Clinical Center, between January 20 and February 29, 2020.Results: 47.4% (154/325) had visited Wuhan within 2 weeks of illness onset. 57.2% occurred in 67 clusters; 40% were situated within 53 family clusters. 83.7% developed fever during the disease course. Median times from onset to first medical care, hospitalization and negative detection of nucleic acid by nasopharyngeal swab were 1, 4 and 8 days. Patients with mild disease using glucocorticoid tended to have longer viral shedding in blood and feces. At admission, 69.8% presented with lymphopenia and 38.8% had elevated D-dimers. Pneumonia was identified in 97.5% (314/322) of cases by chest CT scan. Severe-critical patients were 8% with a median time from onset to critical disease of 10.5 days. Half required oxygen therapy and 7.1% high-flow nasal oxygen. The case fatality rate was 0.92% with median time from onset to death of 16 days.Conclusion: COVID-19 cases in Shanghai were imported. Rapid identification, and effective control measures helped to contain the outbreak and prevent community transmission.https://www.tandfonline.com/doi/10.1080/22221751.2020.1787103COVID-19epidemiologyclinical characteristicsclinical courseviral shedding |
| spellingShingle | Yinzhong Shen Fang Zheng Danfeng Sun Yun Ling Jun Chen Feng Li Tao Li Zhiping Qian Yuyi Zhang Qingnian Xu Li Liu Qin Huang Fei Shan Lie Xu Jun Wu Zhaoqin Zhu Zhigang Song Shenyang Li Yuxin Shi Jianliang Zhang Xueyun Wu Joshua B. Mendelsohn Tongyu Zhu Hongzhou Lu Epidemiology and clinical course of COVID-19 in Shanghai, China Emerging Microbes and Infections COVID-19 epidemiology clinical characteristics clinical course viral shedding |
| title | Epidemiology and clinical course of COVID-19 in Shanghai, China |
| title_full | Epidemiology and clinical course of COVID-19 in Shanghai, China |
| title_fullStr | Epidemiology and clinical course of COVID-19 in Shanghai, China |
| title_full_unstemmed | Epidemiology and clinical course of COVID-19 in Shanghai, China |
| title_short | Epidemiology and clinical course of COVID-19 in Shanghai, China |
| title_sort | epidemiology and clinical course of covid 19 in shanghai china |
| topic | COVID-19 epidemiology clinical characteristics clinical course viral shedding |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2020.1787103 |
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