The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Background. Acute exacerbation of IPF (AE-IPF) is associated with high mortality. We studied changes in pathogen involvement during AE-IPF and explored a possible role of infection in AE-IPF. Objectives. Our purpose is to investigate the role of infection in AE-IPF. Methods. Overall, we recruited 17...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/5160694 |
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| author | Dong Weng Xian-Qiu Chen Hui Qiu Yuan Zhang Qiu-Hong Li Meng-Meng Zhao Qin Wu Tao Chen Yang Hu Liu-Sheng Wang Ya-Ru Wei Yu-Kui Du Shan-Shan Chen Ying Zhou Fen Zhang Li Shen Yi-Liang Su Martin Kolb Hui-Ping Li |
| author_facet | Dong Weng Xian-Qiu Chen Hui Qiu Yuan Zhang Qiu-Hong Li Meng-Meng Zhao Qin Wu Tao Chen Yang Hu Liu-Sheng Wang Ya-Ru Wei Yu-Kui Du Shan-Shan Chen Ying Zhou Fen Zhang Li Shen Yi-Liang Su Martin Kolb Hui-Ping Li |
| author_sort | Dong Weng |
| collection | DOAJ |
| description | Background. Acute exacerbation of IPF (AE-IPF) is associated with high mortality. We studied changes in pathogen involvement during AE-IPF and explored a possible role of infection in AE-IPF. Objectives. Our purpose is to investigate the role of infection in AE-IPF. Methods. Overall, we recruited 170 IPF patients (48 AE-IPF, 122 stable) and 70 controls at Shanghai Pulmonary Hospital. Specific IgM against microbial pathogens and pathogens in sputum were assessed. RNA sequences of pathogens in nasopharyngeal swab of IPF patients were detected by PathChip. A panel of serum parameters reflecting immune function were assessed. Results. Antiviral/bacterial IgM was higher in IPF vs. controls and in AE-IPF vs. stable IPF. Thirty-eight different bacterial strains were detected in IPF patient sputum. Bacteria-positive results were found in 9/48 (18.8%) of AE-IPF and in 26/122 (21.3%) stable IPF. Fifty-seven different viruses were detected in nasopharyngeal swabs of IPF patients. Virus-positive nasopharyngeal swabs were found in 18/30 (60%) of tested AE-IPF and in 13/30 (43.3%) of stable IPF. AE-IPF showed increased inflammatory cytokines (IL-6, IFN-γ, MIG, IL-17, and IL-9) vs. stable IPF and controls. Mortality of AE-IPF in one year (39.5%) was higher compared to stable IPF (28.7%).Conclusions. IPF patients had different colonization with pathogens in sputum and nasopharyngeal swabs; they also displayed abnormally activated immune response, which was exacerbated during AE-IPF. |
| format | Article |
| id | doaj-art-e1e3f606b273437f9c970789c9f472de |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e1e3f606b273437f9c970789c9f472de2025-08-20T02:21:38ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/51606945160694The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary FibrosisDong Weng0Xian-Qiu Chen1Hui Qiu2Yuan Zhang3Qiu-Hong Li4Meng-Meng Zhao5Qin Wu6Tao Chen7Yang Hu8Liu-Sheng Wang9Ya-Ru Wei10Yu-Kui Du11Shan-Shan Chen12Ying Zhou13Fen Zhang14Li Shen15Yi-Liang Su16Martin Kolb17Hui-Ping Li18Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaSchool of Medicine, Suzhou University, Suzhou, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaMcMaster University Hamilton, Department of Medicine and Pathology/Molecular Medicine, ON, CanadaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaBackground. Acute exacerbation of IPF (AE-IPF) is associated with high mortality. We studied changes in pathogen involvement during AE-IPF and explored a possible role of infection in AE-IPF. Objectives. Our purpose is to investigate the role of infection in AE-IPF. Methods. Overall, we recruited 170 IPF patients (48 AE-IPF, 122 stable) and 70 controls at Shanghai Pulmonary Hospital. Specific IgM against microbial pathogens and pathogens in sputum were assessed. RNA sequences of pathogens in nasopharyngeal swab of IPF patients were detected by PathChip. A panel of serum parameters reflecting immune function were assessed. Results. Antiviral/bacterial IgM was higher in IPF vs. controls and in AE-IPF vs. stable IPF. Thirty-eight different bacterial strains were detected in IPF patient sputum. Bacteria-positive results were found in 9/48 (18.8%) of AE-IPF and in 26/122 (21.3%) stable IPF. Fifty-seven different viruses were detected in nasopharyngeal swabs of IPF patients. Virus-positive nasopharyngeal swabs were found in 18/30 (60%) of tested AE-IPF and in 13/30 (43.3%) of stable IPF. AE-IPF showed increased inflammatory cytokines (IL-6, IFN-γ, MIG, IL-17, and IL-9) vs. stable IPF and controls. Mortality of AE-IPF in one year (39.5%) was higher compared to stable IPF (28.7%).Conclusions. IPF patients had different colonization with pathogens in sputum and nasopharyngeal swabs; they also displayed abnormally activated immune response, which was exacerbated during AE-IPF.http://dx.doi.org/10.1155/2019/5160694 |
| spellingShingle | Dong Weng Xian-Qiu Chen Hui Qiu Yuan Zhang Qiu-Hong Li Meng-Meng Zhao Qin Wu Tao Chen Yang Hu Liu-Sheng Wang Ya-Ru Wei Yu-Kui Du Shan-Shan Chen Ying Zhou Fen Zhang Li Shen Yi-Liang Su Martin Kolb Hui-Ping Li The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis Mediators of Inflammation |
| title | The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
| title_full | The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
| title_fullStr | The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
| title_full_unstemmed | The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
| title_short | The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
| title_sort | role of infection in acute exacerbation of idiopathic pulmonary fibrosis |
| url | http://dx.doi.org/10.1155/2019/5160694 |
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