Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects.
<h4>Background</h4>Brain-derived neurotrophic factor (BDNF) is an activity-dependent secreted protein that is critical to organization of neuronal networks and synaptic plasticity, especially in the hippocampus. We tested hypothesis that reduced CSF BDNF is associated with age-related co...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005424&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850240348074278912 |
|---|---|
| author | Ge Li Elaine R Peskind Steven P Millard Peter Chi Izabela Sokal Chang-En Yu Lynn M Bekris Murray A Raskind Douglas R Galasko Thomas J Montine |
| author_facet | Ge Li Elaine R Peskind Steven P Millard Peter Chi Izabela Sokal Chang-En Yu Lynn M Bekris Murray A Raskind Douglas R Galasko Thomas J Montine |
| author_sort | Ge Li |
| collection | DOAJ |
| description | <h4>Background</h4>Brain-derived neurotrophic factor (BDNF) is an activity-dependent secreted protein that is critical to organization of neuronal networks and synaptic plasticity, especially in the hippocampus. We tested hypothesis that reduced CSF BDNF is associated with age-related cognitive decline.<h4>Methodology/principal findings, and conclusions/significance</h4>CSF concentration of BDNF, Abeta(42) and total tau were measured in 128 cognitively normal adults (Normals), 21 patients with Alzheimer's disease (AD), and nine patients with Mild Cognitive Impairment. Apolipoprotein E and BDNF SNP rs6265 genotype were determined. Neuropsychological tests were performed at baseline for all subjects and at follow-up visits in 50 Normals. CSF BDNF level was lower in AD patients compared to age-matched Normals (p = 0.02). CSF BDNF concentration decreased with age among Normals and was higher in women than men (both p<0.001). After adjusting for age, gender, education, CSF Abeta(42) and total tau, and APOE and BDNF genotypes, lower CSF BDNF concentration was associated poorer immediate and delayed recall at baseline (both p<0.05) and in follow up of approximately 3 years duration (both p<0.01).<h4>Conclusions/significance</h4>Reduced CSF BDNF was associated with age-related cognitive decline, suggesting a potential mechanism that may contribute in part to cognitive decline in older individuals. |
| format | Article |
| id | doaj-art-e1e16a8637c14cfbb9fff254c63fddf7 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e1e16a8637c14cfbb9fff254c63fddf72025-08-20T02:00:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-01-0145e542410.1371/journal.pone.0005424Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects.Ge LiElaine R PeskindSteven P MillardPeter ChiIzabela SokalChang-En YuLynn M BekrisMurray A RaskindDouglas R GalaskoThomas J Montine<h4>Background</h4>Brain-derived neurotrophic factor (BDNF) is an activity-dependent secreted protein that is critical to organization of neuronal networks and synaptic plasticity, especially in the hippocampus. We tested hypothesis that reduced CSF BDNF is associated with age-related cognitive decline.<h4>Methodology/principal findings, and conclusions/significance</h4>CSF concentration of BDNF, Abeta(42) and total tau were measured in 128 cognitively normal adults (Normals), 21 patients with Alzheimer's disease (AD), and nine patients with Mild Cognitive Impairment. Apolipoprotein E and BDNF SNP rs6265 genotype were determined. Neuropsychological tests were performed at baseline for all subjects and at follow-up visits in 50 Normals. CSF BDNF level was lower in AD patients compared to age-matched Normals (p = 0.02). CSF BDNF concentration decreased with age among Normals and was higher in women than men (both p<0.001). After adjusting for age, gender, education, CSF Abeta(42) and total tau, and APOE and BDNF genotypes, lower CSF BDNF concentration was associated poorer immediate and delayed recall at baseline (both p<0.05) and in follow up of approximately 3 years duration (both p<0.01).<h4>Conclusions/significance</h4>Reduced CSF BDNF was associated with age-related cognitive decline, suggesting a potential mechanism that may contribute in part to cognitive decline in older individuals.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005424&type=printable |
| spellingShingle | Ge Li Elaine R Peskind Steven P Millard Peter Chi Izabela Sokal Chang-En Yu Lynn M Bekris Murray A Raskind Douglas R Galasko Thomas J Montine Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects. PLoS ONE |
| title | Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects. |
| title_full | Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects. |
| title_fullStr | Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects. |
| title_full_unstemmed | Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects. |
| title_short | Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects. |
| title_sort | cerebrospinal fluid concentration of brain derived neurotrophic factor and cognitive function in non demented subjects |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005424&type=printable |
| work_keys_str_mv | AT geli cerebrospinalfluidconcentrationofbrainderivedneurotrophicfactorandcognitivefunctioninnondementedsubjects AT elainerpeskind cerebrospinalfluidconcentrationofbrainderivedneurotrophicfactorandcognitivefunctioninnondementedsubjects AT stevenpmillard cerebrospinalfluidconcentrationofbrainderivedneurotrophicfactorandcognitivefunctioninnondementedsubjects AT peterchi cerebrospinalfluidconcentrationofbrainderivedneurotrophicfactorandcognitivefunctioninnondementedsubjects AT izabelasokal cerebrospinalfluidconcentrationofbrainderivedneurotrophicfactorandcognitivefunctioninnondementedsubjects AT changenyu cerebrospinalfluidconcentrationofbrainderivedneurotrophicfactorandcognitivefunctioninnondementedsubjects AT lynnmbekris cerebrospinalfluidconcentrationofbrainderivedneurotrophicfactorandcognitivefunctioninnondementedsubjects AT murrayaraskind cerebrospinalfluidconcentrationofbrainderivedneurotrophicfactorandcognitivefunctioninnondementedsubjects AT douglasrgalasko cerebrospinalfluidconcentrationofbrainderivedneurotrophicfactorandcognitivefunctioninnondementedsubjects AT thomasjmontine cerebrospinalfluidconcentrationofbrainderivedneurotrophicfactorandcognitivefunctioninnondementedsubjects |