Hybrid fibres: a new path in tissue regeneration
Abstract Nowadays, various forms of organosilane materials are well established in the field of regenerative medicine, but interestingly, fibrous organosilanes have yet to be described. So far, technological obstacles prevent the preparation of such fibrous materials without any presence of spinnabi...
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| Format: | Article |
| Language: | English |
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Springer
2025-03-01
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| Series: | Journal of Materials Science: Materials in Medicine |
| Online Access: | https://doi.org/10.1007/s10856-025-06875-6 |
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| author | Johana Kulhánková Christopher J. Hobbs Barbora Nikendey Holubová Jakub Erben Miroslava Rysová Jana Musílková Lucie Svobodová Nataliya Romanyuk Veronika Máková |
| author_facet | Johana Kulhánková Christopher J. Hobbs Barbora Nikendey Holubová Jakub Erben Miroslava Rysová Jana Musílková Lucie Svobodová Nataliya Romanyuk Veronika Máková |
| author_sort | Johana Kulhánková |
| collection | DOAJ |
| description | Abstract Nowadays, various forms of organosilane materials are well established in the field of regenerative medicine, but interestingly, fibrous organosilanes have yet to be described. So far, technological obstacles prevent the preparation of such fibrous materials without any presence of spinnability-supporting organic polymers, various types of surfactants, or non-polar organic solvents, which are in many cases highly toxic and economically inconvenient. Recently, these obstacles were overcome by a complex, yet simple, technology combining different science perspectives from supramolecular chemistry through material science to tissue engineering. This paper suggests a synthesis of two biomedically promising monomeric organosilane precursors, N,N´-bis(3-(triethoxysilyl)propyl)terephthalamide (BTT) and N,N´-bis(3-(triethoxysilyl)propyl)pyridine-2,6-dicarboxamide (BTP), which are submitted to a sol-gel process combined with subsequent electrospinning technology. Such a unique procedure not only allows the preparation of toxic-free organosilane fibrous mats by suitable adjustment of sol-gel and electrospinning parameters but also simplifies material production via a one-pot synthesis approach further tuneable with appropriate organosilane precursors. The BTT and BTP fibrous materials prepared displayed not only a promising interface among the materials and 3T3 fibroblast cell lines but moreover, the interaction of nanofibrous materials with stem cells has yielded encouraging outcomes. Stem cell adhesion, proliferation, and differentiation were notably enhanced in the presence of these materials, suggesting a supportive microenvironment conducive to regenerative responses. The ability of the material to modulate the cellular behaviour of stem cells holds promising implications for the development of targeted and effective regenerative therapies. Graphical Abstract |
| format | Article |
| id | doaj-art-e1dfbbee6b1740ce99215ce4823a27c9 |
| institution | DOAJ |
| issn | 1573-4838 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Materials Science: Materials in Medicine |
| spelling | doaj-art-e1dfbbee6b1740ce99215ce4823a27c92025-08-20T02:49:29ZengSpringerJournal of Materials Science: Materials in Medicine1573-48382025-03-0136111510.1007/s10856-025-06875-6Hybrid fibres: a new path in tissue regenerationJohana Kulhánková0Christopher J. Hobbs1Barbora Nikendey Holubová2Jakub Erben3Miroslava Rysová4Jana Musílková5Lucie Svobodová6Nataliya Romanyuk7Veronika Máková8Faculty of Science, Humanities and Education, Technical University of LiberecDepartment of Nanochemistry, Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of LiberecDepartment of Nanochemistry, Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of LiberecDepartment of Nonwovens and Nanofibrous Materials, Faculty of Textile Engineering, Technical University of LiberecDepartment of Applied Biology, Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of LiberecInstitute of Physiology, Czech Academy of ScienceInstitute of Physiology, Czech Academy of ScienceDepartment of Neuroregeneration, Institute of Experimental Medicine, Czech Academy of ScienceDepartment of Nanochemistry, Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of LiberecAbstract Nowadays, various forms of organosilane materials are well established in the field of regenerative medicine, but interestingly, fibrous organosilanes have yet to be described. So far, technological obstacles prevent the preparation of such fibrous materials without any presence of spinnability-supporting organic polymers, various types of surfactants, or non-polar organic solvents, which are in many cases highly toxic and economically inconvenient. Recently, these obstacles were overcome by a complex, yet simple, technology combining different science perspectives from supramolecular chemistry through material science to tissue engineering. This paper suggests a synthesis of two biomedically promising monomeric organosilane precursors, N,N´-bis(3-(triethoxysilyl)propyl)terephthalamide (BTT) and N,N´-bis(3-(triethoxysilyl)propyl)pyridine-2,6-dicarboxamide (BTP), which are submitted to a sol-gel process combined with subsequent electrospinning technology. Such a unique procedure not only allows the preparation of toxic-free organosilane fibrous mats by suitable adjustment of sol-gel and electrospinning parameters but also simplifies material production via a one-pot synthesis approach further tuneable with appropriate organosilane precursors. The BTT and BTP fibrous materials prepared displayed not only a promising interface among the materials and 3T3 fibroblast cell lines but moreover, the interaction of nanofibrous materials with stem cells has yielded encouraging outcomes. Stem cell adhesion, proliferation, and differentiation were notably enhanced in the presence of these materials, suggesting a supportive microenvironment conducive to regenerative responses. The ability of the material to modulate the cellular behaviour of stem cells holds promising implications for the development of targeted and effective regenerative therapies. Graphical Abstracthttps://doi.org/10.1007/s10856-025-06875-6 |
| spellingShingle | Johana Kulhánková Christopher J. Hobbs Barbora Nikendey Holubová Jakub Erben Miroslava Rysová Jana Musílková Lucie Svobodová Nataliya Romanyuk Veronika Máková Hybrid fibres: a new path in tissue regeneration Journal of Materials Science: Materials in Medicine |
| title | Hybrid fibres: a new path in tissue regeneration |
| title_full | Hybrid fibres: a new path in tissue regeneration |
| title_fullStr | Hybrid fibres: a new path in tissue regeneration |
| title_full_unstemmed | Hybrid fibres: a new path in tissue regeneration |
| title_short | Hybrid fibres: a new path in tissue regeneration |
| title_sort | hybrid fibres a new path in tissue regeneration |
| url | https://doi.org/10.1007/s10856-025-06875-6 |
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