Clinical significance of serum glucose to lymphocyte ratio as a prognostic marker in peritoneal dialysis patients
Background The glucose-to-lymphocyte ratio (GLR), a glucose metabolism and systemic inflammatory response parameter, is associated with an adverse prognosis for various diseases. However, the association between serum GLR and prognosis in patients undergoing peritoneal dialysis (PD) is poorly unders...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2224893 |
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| author | Jiexin Chen Ruiying Tang Xiaojiang Zhan Jihong Deng Yanxia Zhang Haibo Long Fenfen Peng Na Tian Yueqiang Wen Xiaoyang Wang Xiaoran Feng Ning Su Xingming Tang Xianfeng Wu Qian Zhou Qingdong Xu |
| author_facet | Jiexin Chen Ruiying Tang Xiaojiang Zhan Jihong Deng Yanxia Zhang Haibo Long Fenfen Peng Na Tian Yueqiang Wen Xiaoyang Wang Xiaoran Feng Ning Su Xingming Tang Xianfeng Wu Qian Zhou Qingdong Xu |
| author_sort | Jiexin Chen |
| collection | DOAJ |
| description | Background The glucose-to-lymphocyte ratio (GLR), a glucose metabolism and systemic inflammatory response parameter, is associated with an adverse prognosis for various diseases. However, the association between serum GLR and prognosis in patients undergoing peritoneal dialysis (PD) is poorly understood.Methods In this multi-center cohort study, 3236 PD patients were consecutively enrolled between 1 January 2009 and 31 December 2018. Patients were divided into four groups according to the quartiles of baseline GLR levels (Q1: GLR ≤ 2.91, Q2:2.91 < GLR ≤ 3.91, Q3:3.91 < GLR < 5.59 and Q4: GLR ≥ 5.59). The primary endpoint was all-cause and cardiovascular disease (CVD) related mortality. The correlation between GLR and mortality was examined using Kaplan–Meier and multivariable Cox proportional analyses.Results During the follow-up period of 45.93 ± 29.01 months, 25.53% (826/3236) patients died, of whom 31% (254/826) were in Q4 (GLR ≥ 5.59). Multivariable analysis revealed that GLR was significantly associated with all-cause mortality (adjusted HR 1.02; CI 1.00 ∼ 1.04, p = .019) and CVD mortality (adjusted HR 1.02; CI 1.00 ∼ 1.04, p = .04). Compared with the Q1 (GLR ≤ 2.91), placement in Q4 was associated with an increased risk of all-cause mortality (adjusted HR: 1.26, 95% CI: 1.02 ∼ 1.56, p = .03) and CVD mortality (adjusted HR 1.76; CI 1.31 ∼ 2.38, p < .001). A nonlinear relationship was found between GLR and all-cause or CVD mortality in patients undergoing PD (p = .032).Conclusion A higher serum GLR level is an independent prognostic factor for all-cause and CVD mortality in patients undergoing PD, suggesting that more attention should be paid to GLR. |
| format | Article |
| id | doaj-art-e1d75678949b406e8090e1602f503e4e |
| institution | OA Journals |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-e1d75678949b406e8090e1602f503e4e2025-08-20T02:16:10ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2023.2224893Clinical significance of serum glucose to lymphocyte ratio as a prognostic marker in peritoneal dialysis patientsJiexin Chen0Ruiying Tang1Xiaojiang Zhan2Jihong Deng3Yanxia Zhang4Haibo Long5Fenfen Peng6Na Tian7Yueqiang Wen8Xiaoyang Wang9Xiaoran Feng10Ning Su11Xingming Tang12Xianfeng Wu13Qian Zhou14Qingdong Xu15Department of Nephrology, Jiangmen Central Hospital, Jiangmen, ChinaDepartment of Nephrology, Jiangmen Central Hospital, Jiangmen, ChinaDepartment of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Nephrology, Jiangmen Central Hospital, Jiangmen, ChinaDepartment of Nephrology, Jiangmen Central Hospital, Jiangmen, ChinaDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, ChinaDepartment of Nephrology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, ChinaDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Nephrology, Jiujiang NO.1 people’s Hospital, Jiujiang, ChinaDepartment of Hematology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Nephrology, DongGuan SongShan Lake Tungwah Hospital, DongGuan, ChinaDepartment of Nephrology, Affiliated Sixth People’s Hospital, Shanghai Jiao Tong Univeristy, Shanghai, ChinaDepartment of Medical Statistics, Clinical Trials Unit, The First Affiliated Hospital, Sun Yat-sen Univeristy, Guangzhou, ChinaDepartment of Nephrology, Jiangmen Central Hospital, Jiangmen, ChinaBackground The glucose-to-lymphocyte ratio (GLR), a glucose metabolism and systemic inflammatory response parameter, is associated with an adverse prognosis for various diseases. However, the association between serum GLR and prognosis in patients undergoing peritoneal dialysis (PD) is poorly understood.Methods In this multi-center cohort study, 3236 PD patients were consecutively enrolled between 1 January 2009 and 31 December 2018. Patients were divided into four groups according to the quartiles of baseline GLR levels (Q1: GLR ≤ 2.91, Q2:2.91 < GLR ≤ 3.91, Q3:3.91 < GLR < 5.59 and Q4: GLR ≥ 5.59). The primary endpoint was all-cause and cardiovascular disease (CVD) related mortality. The correlation between GLR and mortality was examined using Kaplan–Meier and multivariable Cox proportional analyses.Results During the follow-up period of 45.93 ± 29.01 months, 25.53% (826/3236) patients died, of whom 31% (254/826) were in Q4 (GLR ≥ 5.59). Multivariable analysis revealed that GLR was significantly associated with all-cause mortality (adjusted HR 1.02; CI 1.00 ∼ 1.04, p = .019) and CVD mortality (adjusted HR 1.02; CI 1.00 ∼ 1.04, p = .04). Compared with the Q1 (GLR ≤ 2.91), placement in Q4 was associated with an increased risk of all-cause mortality (adjusted HR: 1.26, 95% CI: 1.02 ∼ 1.56, p = .03) and CVD mortality (adjusted HR 1.76; CI 1.31 ∼ 2.38, p < .001). A nonlinear relationship was found between GLR and all-cause or CVD mortality in patients undergoing PD (p = .032).Conclusion A higher serum GLR level is an independent prognostic factor for all-cause and CVD mortality in patients undergoing PD, suggesting that more attention should be paid to GLR.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2224893Peritoneal dialysisglucose to lymphocyte ratioall-cause mortalitycardiovascular mortality |
| spellingShingle | Jiexin Chen Ruiying Tang Xiaojiang Zhan Jihong Deng Yanxia Zhang Haibo Long Fenfen Peng Na Tian Yueqiang Wen Xiaoyang Wang Xiaoran Feng Ning Su Xingming Tang Xianfeng Wu Qian Zhou Qingdong Xu Clinical significance of serum glucose to lymphocyte ratio as a prognostic marker in peritoneal dialysis patients Renal Failure Peritoneal dialysis glucose to lymphocyte ratio all-cause mortality cardiovascular mortality |
| title | Clinical significance of serum glucose to lymphocyte ratio as a prognostic marker in peritoneal dialysis patients |
| title_full | Clinical significance of serum glucose to lymphocyte ratio as a prognostic marker in peritoneal dialysis patients |
| title_fullStr | Clinical significance of serum glucose to lymphocyte ratio as a prognostic marker in peritoneal dialysis patients |
| title_full_unstemmed | Clinical significance of serum glucose to lymphocyte ratio as a prognostic marker in peritoneal dialysis patients |
| title_short | Clinical significance of serum glucose to lymphocyte ratio as a prognostic marker in peritoneal dialysis patients |
| title_sort | clinical significance of serum glucose to lymphocyte ratio as a prognostic marker in peritoneal dialysis patients |
| topic | Peritoneal dialysis glucose to lymphocyte ratio all-cause mortality cardiovascular mortality |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2224893 |
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