Insulin Therapy with Personal Insulin Pumps and Early Angiopathy in Children with Type 1 Diabetes Mellitus
Objective. Assessment of the effect of a treatment method change from multiple daily insulin injection (MDI) to continuous subcutaneous insulin infusion (CSII) on the development of early angiopathy in children with T1DM with or without retinopathy. Methods. The study pump group involved 32 diabetic...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/791283 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550384474783744 |
|---|---|
| author | Joanna Tołwińska Barbara Głowińska-Olszewska Artur Bossowski |
| author_facet | Joanna Tołwińska Barbara Głowińska-Olszewska Artur Bossowski |
| author_sort | Joanna Tołwińska |
| collection | DOAJ |
| description | Objective. Assessment of the effect of a treatment method change from multiple daily insulin injection (MDI) to continuous subcutaneous insulin infusion (CSII) on the development of early angiopathy in children with T1DM with or without retinopathy. Methods. The study pump group involved 32 diabetic children aged 14.8, with the initial HbA1c level of 8.3%, previously treated by MDI. The patients were examined before pump insertion and after 3 and 6 months of CSII. We assessed HbA1c level, carotid artery intima-media thickness (c-IMT), and flow-mediated dilatation (FMD) of the brachial artery. The pump group was compared to a group of eight teenagers with diagnosed nonproliferative retinopathy, treated with MDI. Results. HbA1c in the entire group was found to improve in the second and in the third examination. During 6 months of CSII, FMD increased and IMT decreased. Retinopathic adolescents had significantly thicker IMT and lower FMD compared to baseline results of the pump group. Treatment intensification in the retinopathy-free children enhanced these differences. Conclusions. CSII is associated with lower IMT and higher FMD. Whether on the long-run CSII is superior to MDI to delay the occurrence of diabetes late complications remains to be explained. |
| format | Article |
| id | doaj-art-e1d6d38fa74a49c78865884e484039fd |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e1d6d38fa74a49c78865884e484039fd2025-02-03T06:06:59ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/791283791283Insulin Therapy with Personal Insulin Pumps and Early Angiopathy in Children with Type 1 Diabetes MellitusJoanna Tołwińska0Barbara Głowińska-Olszewska1Artur Bossowski2Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Białystok, Białystok University Children's Hospital, 17 Waszyngtona Street, 15-274 Bialystok, PolandDepartment of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Białystok, Białystok University Children's Hospital, 17 Waszyngtona Street, 15-274 Bialystok, PolandDepartment of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Białystok, Białystok University Children's Hospital, 17 Waszyngtona Street, 15-274 Bialystok, PolandObjective. Assessment of the effect of a treatment method change from multiple daily insulin injection (MDI) to continuous subcutaneous insulin infusion (CSII) on the development of early angiopathy in children with T1DM with or without retinopathy. Methods. The study pump group involved 32 diabetic children aged 14.8, with the initial HbA1c level of 8.3%, previously treated by MDI. The patients were examined before pump insertion and after 3 and 6 months of CSII. We assessed HbA1c level, carotid artery intima-media thickness (c-IMT), and flow-mediated dilatation (FMD) of the brachial artery. The pump group was compared to a group of eight teenagers with diagnosed nonproliferative retinopathy, treated with MDI. Results. HbA1c in the entire group was found to improve in the second and in the third examination. During 6 months of CSII, FMD increased and IMT decreased. Retinopathic adolescents had significantly thicker IMT and lower FMD compared to baseline results of the pump group. Treatment intensification in the retinopathy-free children enhanced these differences. Conclusions. CSII is associated with lower IMT and higher FMD. Whether on the long-run CSII is superior to MDI to delay the occurrence of diabetes late complications remains to be explained.http://dx.doi.org/10.1155/2013/791283 |
| spellingShingle | Joanna Tołwińska Barbara Głowińska-Olszewska Artur Bossowski Insulin Therapy with Personal Insulin Pumps and Early Angiopathy in Children with Type 1 Diabetes Mellitus Mediators of Inflammation |
| title | Insulin Therapy with Personal Insulin Pumps and Early Angiopathy in Children with Type 1 Diabetes Mellitus |
| title_full | Insulin Therapy with Personal Insulin Pumps and Early Angiopathy in Children with Type 1 Diabetes Mellitus |
| title_fullStr | Insulin Therapy with Personal Insulin Pumps and Early Angiopathy in Children with Type 1 Diabetes Mellitus |
| title_full_unstemmed | Insulin Therapy with Personal Insulin Pumps and Early Angiopathy in Children with Type 1 Diabetes Mellitus |
| title_short | Insulin Therapy with Personal Insulin Pumps and Early Angiopathy in Children with Type 1 Diabetes Mellitus |
| title_sort | insulin therapy with personal insulin pumps and early angiopathy in children with type 1 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2013/791283 |
| work_keys_str_mv | AT joannatołwinska insulintherapywithpersonalinsulinpumpsandearlyangiopathyinchildrenwithtype1diabetesmellitus AT barbaragłowinskaolszewska insulintherapywithpersonalinsulinpumpsandearlyangiopathyinchildrenwithtype1diabetesmellitus AT arturbossowski insulintherapywithpersonalinsulinpumpsandearlyangiopathyinchildrenwithtype1diabetesmellitus |