Exogenous hydrogen sulphide sensitizes carbapenemase-producing Acinetobacter baumannii to gentamicin
Objective: Carbapenem-resistant Acinetobacter baumannii pose a major public health threat. These bacteria often display broad-spectrum antibiotic resistance, rendering them resistant to nearly all classes of antibiotics. Hydrogen sulphide (H2S), a compound naturally produced by many bacterial specie...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
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| Series: | Journal of Global Antimicrobial Resistance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716525000888 |
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| Summary: | Objective: Carbapenem-resistant Acinetobacter baumannii pose a major public health threat. These bacteria often display broad-spectrum antibiotic resistance, rendering them resistant to nearly all classes of antibiotics. Hydrogen sulphide (H2S), a compound naturally produced by many bacterial species, has been proposed to exert a protective effect against certain antibiotics. However, A. baumannii does not produced H2S. Methods: To investigate the effect of exogenous H2S on antibiotic resistance, several clinical isolates of carbapenemase-producing A. baumannii were cultured under various conditions, including the presence or absence of H2S and/or sub-inhibitory concentrations of gentamicin, azithromycin, ciprofloxacin, tetracycline, and meropenem. Bacterial growth was assessed at multiple time points to evaluate growth dynamics. Results: Exogenous H2S alone had a limited impact on bacterial growth. However, its addition reduced the minimum inhibitory concentration of gentamicin and sensitized the bacteria to sub-inhibitory concentrations of this antibiotic. Conclusions: This study highlights the potential of H2S as an antibiotic potentiator, suggesting that the use of this combination may be a promising strategy for treating pulmonary infections caused by A. baumannii or for preventing colonization on medical devices such as catheters. |
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| ISSN: | 2213-7165 |