The Red Blood Cell as a Gender-Associated Biomarker in Metabolic Syndrome: A Pilot Study
In the present pilot study (56 patients), some red blood cell parameters in samples from patients with metabolic syndrome and subclinical atherosclerosis, but without any sign of coronary artery disease, have been analyzed. The main goal of this work was to determine, in this preclinical state, new...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2011/204157 |
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| author | Elisabetta Straface Lucrezia Gambardella Antonella Mattatelli Emanuele Canali Francesca Boccalini Luciano Agati Walter Malorni |
| author_facet | Elisabetta Straface Lucrezia Gambardella Antonella Mattatelli Emanuele Canali Francesca Boccalini Luciano Agati Walter Malorni |
| author_sort | Elisabetta Straface |
| collection | DOAJ |
| description | In the present pilot study (56 patients), some red blood cell parameters in samples from patients with metabolic syndrome and subclinical atherosclerosis, but without any sign of coronary artery disease, have been analyzed. The main goal of this work was to determine, in this preclinical state, new peripheral gender-associated bioindicators of possible diagnostic or prognostic value. In particular, three different “indicators” of red blood cell injury and aging have been evaluated: glycophorin A, CD47, and phosphatidylserine externalization. Interestingly, all these determinants appeared significantly modified and displayed gender differences. These findings could provide novel and useful hints in the research for gender-based real-time bioindicators in the progression of metabolic syndrome towards coronary artery disease. Further, more extensive studies are, however, necessary in order to validate these findings. |
| format | Article |
| id | doaj-art-e1cf393f6a124ad780be2b52273642b2 |
| institution | DOAJ |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-e1cf393f6a124ad780be2b52273642b22025-08-20T03:20:59ZengWileyInternational Journal of Cell Biology1687-88761687-88842011-01-01201110.1155/2011/204157204157The Red Blood Cell as a Gender-Associated Biomarker in Metabolic Syndrome: A Pilot StudyElisabetta Straface0Lucrezia Gambardella1Antonella Mattatelli2Emanuele Canali3Francesca Boccalini4Luciano Agati5Walter Malorni6Section of Cell Degeneration and Gender Medicine, Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, ItalySection of Cell Degeneration and Gender Medicine, Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, ItalyDepartment of Cardiology, “Sapienza” University, 00161, Rome, ItalyDepartment of Cardiology, “Sapienza” University, 00161, Rome, ItalyDepartment of Cardiology, “Sapienza” University, 00161, Rome, ItalyDepartment of Cardiology, “Sapienza” University, 00161, Rome, ItalySection of Cell Degeneration and Gender Medicine, Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, ItalyIn the present pilot study (56 patients), some red blood cell parameters in samples from patients with metabolic syndrome and subclinical atherosclerosis, but without any sign of coronary artery disease, have been analyzed. The main goal of this work was to determine, in this preclinical state, new peripheral gender-associated bioindicators of possible diagnostic or prognostic value. In particular, three different “indicators” of red blood cell injury and aging have been evaluated: glycophorin A, CD47, and phosphatidylserine externalization. Interestingly, all these determinants appeared significantly modified and displayed gender differences. These findings could provide novel and useful hints in the research for gender-based real-time bioindicators in the progression of metabolic syndrome towards coronary artery disease. Further, more extensive studies are, however, necessary in order to validate these findings.http://dx.doi.org/10.1155/2011/204157 |
| spellingShingle | Elisabetta Straface Lucrezia Gambardella Antonella Mattatelli Emanuele Canali Francesca Boccalini Luciano Agati Walter Malorni The Red Blood Cell as a Gender-Associated Biomarker in Metabolic Syndrome: A Pilot Study International Journal of Cell Biology |
| title | The Red Blood Cell as a Gender-Associated Biomarker in Metabolic Syndrome: A Pilot Study |
| title_full | The Red Blood Cell as a Gender-Associated Biomarker in Metabolic Syndrome: A Pilot Study |
| title_fullStr | The Red Blood Cell as a Gender-Associated Biomarker in Metabolic Syndrome: A Pilot Study |
| title_full_unstemmed | The Red Blood Cell as a Gender-Associated Biomarker in Metabolic Syndrome: A Pilot Study |
| title_short | The Red Blood Cell as a Gender-Associated Biomarker in Metabolic Syndrome: A Pilot Study |
| title_sort | red blood cell as a gender associated biomarker in metabolic syndrome a pilot study |
| url | http://dx.doi.org/10.1155/2011/204157 |
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