TRIM65 as a key regulator of ferroptosis and glycolysis in lactate-driven renal tubular injury and diabetic kidney disease

TRIM65 as a key regulator of ferroptosis and glycolysis in lactate-driven renal tubular injury and diabetic kidney disease

Summary: Recent studies have highlighted the critical role of renal tubular epithelial cell (TEC) damage in the progression of diabetic kidney disease (DKD), where lactate accumulation is closely associated with TEC injury despite unclear mechanisms. This study demonstrates that TRIM65 knockout exac...

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Bibliographic Details
Main Authors: Guangyan Yang, Xiaomai Liu, Yanchun Li, Lixing Li, Jiaqing Xiang, Zhen Liang, Meixiu Jiang, Shu Yang
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725008629
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