Interleukin-35 inhibits NETs to ameliorate Th17/Treg immune imbalance during the exacerbation of cigarette smoke exposed-asthma via gp130/STAT3/ferroptosis axis

Interleukin-35 inhibits NETs to ameliorate Th17/Treg immune imbalance during the exacerbation of cigarette smoke exposed-asthma via gp130/STAT3/ferroptosis axis

Cigarette smoke (CS) exposure amplifies neutrophil accumulation. IL-35, a novel cytokine with anti-inflammatory properties, is involved in protection against asthma. However, the biological roles of neutrophils and the precise molecular mechanisms of IL-35 in CS exposed-asthma remain unclear. We sho...

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Bibliographic Details
Main Authors: Peizhi Tao, Beiting Su, Xueyan Mao, Yusen Lin, Li Zheng, Xiaoling Zou, Hailing Yang, Jing Liu, Hongtao Li
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Redox Biology
Subjects:
Interleukin-35
Neutrophil extracellular traps
Th17 cell
Treg cell
Cigarette smoke exposed-asthma
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001077
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