Reduced Verbal Fluency following Subthalamic Deep Brain Stimulation: A Frontal-Related Cognitive Deficit?
<h4>Objective</h4>The decrease in verbal fluency in patients with Parkinson's disease (PD) undergoing subthalamic nucleus deep brain stimulation (STN-DBS) is usually assumed to reflect a frontal lobe-related cognitive dysfunction, although evidence for this is lacking.<h4>Meth...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0140083&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849723588657020928 |
|---|---|
| author | Jean-François Houvenaghel Florence Le Jeune Thibaut Dondaine Aurore Esquevin Gabriel Hadrien Robert Julie Péron Claire Haegelen Sophie Drapier Pierre Jannin Clément Lozachmeur Soizic Argaud Joan Duprez Dominique Drapier Marc Vérin Paul Sauleau |
| author_facet | Jean-François Houvenaghel Florence Le Jeune Thibaut Dondaine Aurore Esquevin Gabriel Hadrien Robert Julie Péron Claire Haegelen Sophie Drapier Pierre Jannin Clément Lozachmeur Soizic Argaud Joan Duprez Dominique Drapier Marc Vérin Paul Sauleau |
| author_sort | Jean-François Houvenaghel |
| collection | DOAJ |
| description | <h4>Objective</h4>The decrease in verbal fluency in patients with Parkinson's disease (PD) undergoing subthalamic nucleus deep brain stimulation (STN-DBS) is usually assumed to reflect a frontal lobe-related cognitive dysfunction, although evidence for this is lacking.<h4>Methods</h4>To explore its underlying mechanisms, we combined neuropsychological, psychiatric and motor assessments with an examination of brain metabolism using F-18 fluorodeoxyglucose positron emission tomography, in 26 patients with PD, 3 months before and after surgery. We divided these patients into two groups, depending on whether or not they exhibited a postoperative deterioration in either phonemic (10 patients) or semantic (8 patients) fluency. We then compared the STN-DBS groups with and without verbal deterioration on changes in clinical measures and brain metabolism.<h4>Results</h4>We did not find any neuropsychological change supporting the presence of an executive dysfunction in patients with a deficit in either phonemic or semantic fluency. Similarly, a comparison of patients with or without impaired fluency on brain metabolism failed to highlight any frontal areas involved in cognitive functions. However, greater changes in cognitive slowdown and apathy were observed in patients with a postoperative decrease in verbal fluency.<h4>Conclusions</h4>These results suggest that frontal lobe-related cognitive dysfunction could play only a minor role in the postoperative impairment of phonemic or semantic fluency, and that cognitive slowdown and apathy could have a more decisive influence. Furthermore, the phonemic and semantic impairments appeared to result from the disturbance of distinct mechanisms. |
| format | Article |
| id | doaj-art-e1c42437c9b0417f8f0d6719e1f6b6c5 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e1c42437c9b0417f8f0d6719e1f6b6c52025-08-20T03:10:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011010e014008310.1371/journal.pone.0140083Reduced Verbal Fluency following Subthalamic Deep Brain Stimulation: A Frontal-Related Cognitive Deficit?Jean-François HouvenaghelFlorence Le JeuneThibaut DondaineAurore EsquevinGabriel Hadrien RobertJulie PéronClaire HaegelenSophie DrapierPierre JanninClément LozachmeurSoizic ArgaudJoan DuprezDominique DrapierMarc VérinPaul Sauleau<h4>Objective</h4>The decrease in verbal fluency in patients with Parkinson's disease (PD) undergoing subthalamic nucleus deep brain stimulation (STN-DBS) is usually assumed to reflect a frontal lobe-related cognitive dysfunction, although evidence for this is lacking.<h4>Methods</h4>To explore its underlying mechanisms, we combined neuropsychological, psychiatric and motor assessments with an examination of brain metabolism using F-18 fluorodeoxyglucose positron emission tomography, in 26 patients with PD, 3 months before and after surgery. We divided these patients into two groups, depending on whether or not they exhibited a postoperative deterioration in either phonemic (10 patients) or semantic (8 patients) fluency. We then compared the STN-DBS groups with and without verbal deterioration on changes in clinical measures and brain metabolism.<h4>Results</h4>We did not find any neuropsychological change supporting the presence of an executive dysfunction in patients with a deficit in either phonemic or semantic fluency. Similarly, a comparison of patients with or without impaired fluency on brain metabolism failed to highlight any frontal areas involved in cognitive functions. However, greater changes in cognitive slowdown and apathy were observed in patients with a postoperative decrease in verbal fluency.<h4>Conclusions</h4>These results suggest that frontal lobe-related cognitive dysfunction could play only a minor role in the postoperative impairment of phonemic or semantic fluency, and that cognitive slowdown and apathy could have a more decisive influence. Furthermore, the phonemic and semantic impairments appeared to result from the disturbance of distinct mechanisms.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0140083&type=printable |
| spellingShingle | Jean-François Houvenaghel Florence Le Jeune Thibaut Dondaine Aurore Esquevin Gabriel Hadrien Robert Julie Péron Claire Haegelen Sophie Drapier Pierre Jannin Clément Lozachmeur Soizic Argaud Joan Duprez Dominique Drapier Marc Vérin Paul Sauleau Reduced Verbal Fluency following Subthalamic Deep Brain Stimulation: A Frontal-Related Cognitive Deficit? PLoS ONE |
| title | Reduced Verbal Fluency following Subthalamic Deep Brain Stimulation: A Frontal-Related Cognitive Deficit? |
| title_full | Reduced Verbal Fluency following Subthalamic Deep Brain Stimulation: A Frontal-Related Cognitive Deficit? |
| title_fullStr | Reduced Verbal Fluency following Subthalamic Deep Brain Stimulation: A Frontal-Related Cognitive Deficit? |
| title_full_unstemmed | Reduced Verbal Fluency following Subthalamic Deep Brain Stimulation: A Frontal-Related Cognitive Deficit? |
| title_short | Reduced Verbal Fluency following Subthalamic Deep Brain Stimulation: A Frontal-Related Cognitive Deficit? |
| title_sort | reduced verbal fluency following subthalamic deep brain stimulation a frontal related cognitive deficit |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0140083&type=printable |
| work_keys_str_mv | AT jeanfrancoishouvenaghel reducedverbalfluencyfollowingsubthalamicdeepbrainstimulationafrontalrelatedcognitivedeficit AT florencelejeune reducedverbalfluencyfollowingsubthalamicdeepbrainstimulationafrontalrelatedcognitivedeficit AT thibautdondaine reducedverbalfluencyfollowingsubthalamicdeepbrainstimulationafrontalrelatedcognitivedeficit AT auroreesquevin reducedverbalfluencyfollowingsubthalamicdeepbrainstimulationafrontalrelatedcognitivedeficit AT gabrielhadrienrobert reducedverbalfluencyfollowingsubthalamicdeepbrainstimulationafrontalrelatedcognitivedeficit AT julieperon reducedverbalfluencyfollowingsubthalamicdeepbrainstimulationafrontalrelatedcognitivedeficit AT clairehaegelen reducedverbalfluencyfollowingsubthalamicdeepbrainstimulationafrontalrelatedcognitivedeficit AT sophiedrapier reducedverbalfluencyfollowingsubthalamicdeepbrainstimulationafrontalrelatedcognitivedeficit AT pierrejannin reducedverbalfluencyfollowingsubthalamicdeepbrainstimulationafrontalrelatedcognitivedeficit AT clementlozachmeur reducedverbalfluencyfollowingsubthalamicdeepbrainstimulationafrontalrelatedcognitivedeficit AT soizicargaud reducedverbalfluencyfollowingsubthalamicdeepbrainstimulationafrontalrelatedcognitivedeficit AT joanduprez reducedverbalfluencyfollowingsubthalamicdeepbrainstimulationafrontalrelatedcognitivedeficit AT dominiquedrapier reducedverbalfluencyfollowingsubthalamicdeepbrainstimulationafrontalrelatedcognitivedeficit AT marcverin reducedverbalfluencyfollowingsubthalamicdeepbrainstimulationafrontalrelatedcognitivedeficit AT paulsauleau reducedverbalfluencyfollowingsubthalamicdeepbrainstimulationafrontalrelatedcognitivedeficit |