Diagnostic Challenges and Treatment of Concurrent Toxoplasmosis and Disseminated Cryptococcus in an Immunocompromised Patient
Conclusion: Diagnosing concurrent cryptococcal and toxoplasma infections is challenging due to overlapping clinical symptoms and variability in test sensitivities. This case underscores the need for a comprehensive diagnostic approach and the critical role of brain biopsy when other diagnostic metho...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/crdi/9917703 |
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| author | Jeffrey Valencia Uribe Ann-Katrin Valencia Brian Nudelman Nicole Nudelman Dante P. Melendez Lecca |
| author_facet | Jeffrey Valencia Uribe Ann-Katrin Valencia Brian Nudelman Nicole Nudelman Dante P. Melendez Lecca |
| author_sort | Jeffrey Valencia Uribe |
| collection | DOAJ |
| description | Conclusion: Diagnosing concurrent cryptococcal and toxoplasma infections is challenging due to overlapping clinical symptoms and variability in test sensitivities. This case underscores the need for a comprehensive diagnostic approach and the critical role of brain biopsy when other diagnostic methods, such as Karius testing and CSF PCR, are inconclusive. Prompt empirical treatment based on clinical suspicion, with subsequent treatment adjustments guided by clinical response and follow-up assessments, is essential for effective management. |
| format | Article |
| id | doaj-art-e1c2601de768417a88b8d6c2ccbd69a8 |
| institution | Kabale University |
| issn | 2090-6633 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-e1c2601de768417a88b8d6c2ccbd69a82025-08-20T03:24:27ZengWileyCase Reports in Infectious Diseases2090-66332025-01-01202510.1155/crdi/9917703Diagnostic Challenges and Treatment of Concurrent Toxoplasmosis and Disseminated Cryptococcus in an Immunocompromised PatientJeffrey Valencia Uribe0Ann-Katrin Valencia1Brian Nudelman2Nicole Nudelman3Dante P. Melendez Lecca4Internal MedicineInternal MedicineInternal MedicineInternal MedicineDivision of Infectious DiseaseConclusion: Diagnosing concurrent cryptococcal and toxoplasma infections is challenging due to overlapping clinical symptoms and variability in test sensitivities. This case underscores the need for a comprehensive diagnostic approach and the critical role of brain biopsy when other diagnostic methods, such as Karius testing and CSF PCR, are inconclusive. Prompt empirical treatment based on clinical suspicion, with subsequent treatment adjustments guided by clinical response and follow-up assessments, is essential for effective management.http://dx.doi.org/10.1155/crdi/9917703 |
| spellingShingle | Jeffrey Valencia Uribe Ann-Katrin Valencia Brian Nudelman Nicole Nudelman Dante P. Melendez Lecca Diagnostic Challenges and Treatment of Concurrent Toxoplasmosis and Disseminated Cryptococcus in an Immunocompromised Patient Case Reports in Infectious Diseases |
| title | Diagnostic Challenges and Treatment of Concurrent Toxoplasmosis and Disseminated Cryptococcus in an Immunocompromised Patient |
| title_full | Diagnostic Challenges and Treatment of Concurrent Toxoplasmosis and Disseminated Cryptococcus in an Immunocompromised Patient |
| title_fullStr | Diagnostic Challenges and Treatment of Concurrent Toxoplasmosis and Disseminated Cryptococcus in an Immunocompromised Patient |
| title_full_unstemmed | Diagnostic Challenges and Treatment of Concurrent Toxoplasmosis and Disseminated Cryptococcus in an Immunocompromised Patient |
| title_short | Diagnostic Challenges and Treatment of Concurrent Toxoplasmosis and Disseminated Cryptococcus in an Immunocompromised Patient |
| title_sort | diagnostic challenges and treatment of concurrent toxoplasmosis and disseminated cryptococcus in an immunocompromised patient |
| url | http://dx.doi.org/10.1155/crdi/9917703 |
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