Zein-Gum Arabic Loaded with Dihydromyricetin: Preparation and Analysis of Nanoparticles
In this study, dihydromyricetin (DMY) was used as the core to construct nanoparticles, and DMY was encapsulated by nanoparticles to solve the problems of poor water solubility and poor stability, so as to improve its utilization and biological activity. The anti-solvent precipitation method was used...
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The editorial department of Science and Technology of Food Industry
2025-06-01
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| Series: | Shipin gongye ke-ji |
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| Online Access: | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024050400 |
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| author | Dawei CHANG Jiayi CAO Na REN Huxuan WANG Yujiao SUN Wen SHEN Sendi SARA |
| author_facet | Dawei CHANG Jiayi CAO Na REN Huxuan WANG Yujiao SUN Wen SHEN Sendi SARA |
| author_sort | Dawei CHANG |
| collection | DOAJ |
| description | In this study, dihydromyricetin (DMY) was used as the core to construct nanoparticles, and DMY was encapsulated by nanoparticles to solve the problems of poor water solubility and poor stability, so as to improve its utilization and biological activity. The anti-solvent precipitation method was used to develop a Zein-gum Arabic (GA) nano nutrient delivery system with DMY as the core material and Zein as the carrier. The preparation conditions of Zein/GA-DMY nanoparticles were optimized based on particle size, polydispersity index (PDI), zeta potential, and encapsulation efficiency. The interactions among Zein, GA, and DMY were examined using Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD), while the system's microscopic morphology was observed through scanning electron microscopy (SEM). The results indicated that when the mass ratio of Zein to GA was 1:2 and the mass ratio of Zein to DMY was 10:1, the nanoparticles achieved a small particle size (191.04 nm), a PDI of 0.164, a zeta potential of −17.70 mV, and an encapsulation efficiency of 76.17%. Hydrogen bonding, electrostatic interactions, and hydrophobic interactions were identified as the primary forces driving nanoparticle formation. DMY was successfully encapsulated in an amorphous state within the Zein/GA-DMY nanoparticles, which were spherical and uniformly distributed. The incorporation of GA enhanced the nanoparticles' stability under varying pH, heat, salt ion concentration, and storage conditions, broadening their potential applications. In vitro antioxidant assays and simulated gastrointestinal digestion experiments demonstrated that DMY retained significant antioxidant activity post-encapsulation and exhibited a slow-release profile. This study provides a theoretical foundation for the application of DMY in functional foods. |
| format | Article |
| id | doaj-art-e1bd3bf4df51468285f70bb6b840ceda |
| institution | Kabale University |
| issn | 1002-0306 |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | The editorial department of Science and Technology of Food Industry |
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| series | Shipin gongye ke-ji |
| spelling | doaj-art-e1bd3bf4df51468285f70bb6b840ceda2025-08-20T03:46:53ZzhoThe editorial department of Science and Technology of Food IndustryShipin gongye ke-ji1002-03062025-06-014612304010.13386/j.issn1002-0306.20240504002024050400-12Zein-Gum Arabic Loaded with Dihydromyricetin: Preparation and Analysis of NanoparticlesDawei CHANG0Jiayi CAO1Na REN2Huxuan WANG3Yujiao SUN4Wen SHEN5Sendi SARA6College of Food Science and Engineering, Shaanxi University of Science & Technology, Xi'an 710021, ChinaCollege of Food Science and Engineering, Shaanxi University of Science & Technology, Xi'an 710021, ChinaCollege of Food Science and Engineering, Shaanxi University of Science & Technology, Xi'an 710021, ChinaCollege of Food Science and Engineering, Shaanxi University of Science & Technology, Xi'an 710021, ChinaCollege of Food Science and Engineering, Shaanxi University of Science & Technology, Xi'an 710021, ChinaCollege of Food Science and Engineering, Shaanxi University of Science & Technology, Xi'an 710021, ChinaCollege of Food Science and Engineering, Shaanxi University of Science & Technology, Xi'an 710021, ChinaIn this study, dihydromyricetin (DMY) was used as the core to construct nanoparticles, and DMY was encapsulated by nanoparticles to solve the problems of poor water solubility and poor stability, so as to improve its utilization and biological activity. The anti-solvent precipitation method was used to develop a Zein-gum Arabic (GA) nano nutrient delivery system with DMY as the core material and Zein as the carrier. The preparation conditions of Zein/GA-DMY nanoparticles were optimized based on particle size, polydispersity index (PDI), zeta potential, and encapsulation efficiency. The interactions among Zein, GA, and DMY were examined using Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD), while the system's microscopic morphology was observed through scanning electron microscopy (SEM). The results indicated that when the mass ratio of Zein to GA was 1:2 and the mass ratio of Zein to DMY was 10:1, the nanoparticles achieved a small particle size (191.04 nm), a PDI of 0.164, a zeta potential of −17.70 mV, and an encapsulation efficiency of 76.17%. Hydrogen bonding, electrostatic interactions, and hydrophobic interactions were identified as the primary forces driving nanoparticle formation. DMY was successfully encapsulated in an amorphous state within the Zein/GA-DMY nanoparticles, which were spherical and uniformly distributed. The incorporation of GA enhanced the nanoparticles' stability under varying pH, heat, salt ion concentration, and storage conditions, broadening their potential applications. In vitro antioxidant assays and simulated gastrointestinal digestion experiments demonstrated that DMY retained significant antioxidant activity post-encapsulation and exhibited a slow-release profile. This study provides a theoretical foundation for the application of DMY in functional foods.http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024050400dihydromyricetinzeingum arabicnanoparticlesstabilitybioavailabilitycore-shell structure |
| spellingShingle | Dawei CHANG Jiayi CAO Na REN Huxuan WANG Yujiao SUN Wen SHEN Sendi SARA Zein-Gum Arabic Loaded with Dihydromyricetin: Preparation and Analysis of Nanoparticles Shipin gongye ke-ji dihydromyricetin zein gum arabic nanoparticles stability bioavailability core-shell structure |
| title | Zein-Gum Arabic Loaded with Dihydromyricetin: Preparation and Analysis of Nanoparticles |
| title_full | Zein-Gum Arabic Loaded with Dihydromyricetin: Preparation and Analysis of Nanoparticles |
| title_fullStr | Zein-Gum Arabic Loaded with Dihydromyricetin: Preparation and Analysis of Nanoparticles |
| title_full_unstemmed | Zein-Gum Arabic Loaded with Dihydromyricetin: Preparation and Analysis of Nanoparticles |
| title_short | Zein-Gum Arabic Loaded with Dihydromyricetin: Preparation and Analysis of Nanoparticles |
| title_sort | zein gum arabic loaded with dihydromyricetin preparation and analysis of nanoparticles |
| topic | dihydromyricetin zein gum arabic nanoparticles stability bioavailability core-shell structure |
| url | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024050400 |
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