Novel delivery systems for phages and lysins in the topical management of wound infections: a narrative review
Currently, multidrug-resistant (MDR) bacterial wound infections (WIs) are an extremely challenging clinical problem for physicians. Recently, compared to traditional single liquid delivery drugs, the study of five novel drug delivery systems (i.e., hydrogel, liposomes, electrospun fibers, nanopartic...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1526096/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585033246834688 |
|---|---|
| author | Pan Yang Jing Li Xiumei Ma Nan Hu Zhangyong Song Bin Chen Shizhu Li |
| author_facet | Pan Yang Jing Li Xiumei Ma Nan Hu Zhangyong Song Bin Chen Shizhu Li |
| author_sort | Pan Yang |
| collection | DOAJ |
| description | Currently, multidrug-resistant (MDR) bacterial wound infections (WIs) are an extremely challenging clinical problem for physicians. Recently, compared to traditional single liquid delivery drugs, the study of five novel drug delivery systems (i.e., hydrogel, liposomes, electrospun fibers, nanoparticles and nanoemulsion) for phages and their encoded lysins in WI management has become a hot topic. To assess the current landscape of these emerging technologies, we conducted a comprehensive literature search across PubMed, Scopus and Web of Science up to July 2024, using terms such as “phage,” “lysin,” “wound,” “hydrogel,” “liposomes,” “fibers,” “nanoparticles,” and “nanoemulsion.” The criteria included original studies of five novel delivery systems for phages and lysins in WI management. The findings highlighted the positive effects of the five novel delivery systems for phages and lysins in WI management, significantly reducing wound bacterial populations, and accelerating healing at the injury site. However, the available literature on novel delivery systems for phages and lysins remains limited, particularly for lysins. In conclusion, the application of novel drug delivery systems for phages and lysins showed great potential in combating MDR bacterial WIs. |
| format | Article |
| id | doaj-art-e1bd379b15194845a225db13d4332121 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-e1bd379b15194845a225db13d43321212025-01-27T06:40:19ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-01-011610.3389/fmicb.2025.15260961526096Novel delivery systems for phages and lysins in the topical management of wound infections: a narrative reviewPan Yang0Jing Li1Xiumei Ma2Nan Hu3Zhangyong Song4Bin Chen5Shizhu Li6Postdoctoral Research Station, Guangzhou Bay Area Institute of Biomedicine, Guangzhou, ChinaSchool of Basic Medical Sciences, Southwest Medical University, Luzhou, ChinaSichuan Provincial Key Laboratory for Human Disease Gene Study and Department of Laboratory Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Dermatology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaSchool of Basic Medical Sciences, Southwest Medical University, Luzhou, ChinaPostdoctoral Research Station, Guangzhou Bay Area Institute of Biomedicine, Guangzhou, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaCurrently, multidrug-resistant (MDR) bacterial wound infections (WIs) are an extremely challenging clinical problem for physicians. Recently, compared to traditional single liquid delivery drugs, the study of five novel drug delivery systems (i.e., hydrogel, liposomes, electrospun fibers, nanoparticles and nanoemulsion) for phages and their encoded lysins in WI management has become a hot topic. To assess the current landscape of these emerging technologies, we conducted a comprehensive literature search across PubMed, Scopus and Web of Science up to July 2024, using terms such as “phage,” “lysin,” “wound,” “hydrogel,” “liposomes,” “fibers,” “nanoparticles,” and “nanoemulsion.” The criteria included original studies of five novel delivery systems for phages and lysins in WI management. The findings highlighted the positive effects of the five novel delivery systems for phages and lysins in WI management, significantly reducing wound bacterial populations, and accelerating healing at the injury site. However, the available literature on novel delivery systems for phages and lysins remains limited, particularly for lysins. In conclusion, the application of novel drug delivery systems for phages and lysins showed great potential in combating MDR bacterial WIs.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1526096/fullwoundphagelysinmultidrug-resistanttherapy |
| spellingShingle | Pan Yang Jing Li Xiumei Ma Nan Hu Zhangyong Song Bin Chen Shizhu Li Novel delivery systems for phages and lysins in the topical management of wound infections: a narrative review Frontiers in Microbiology wound phage lysin multidrug-resistant therapy |
| title | Novel delivery systems for phages and lysins in the topical management of wound infections: a narrative review |
| title_full | Novel delivery systems for phages and lysins in the topical management of wound infections: a narrative review |
| title_fullStr | Novel delivery systems for phages and lysins in the topical management of wound infections: a narrative review |
| title_full_unstemmed | Novel delivery systems for phages and lysins in the topical management of wound infections: a narrative review |
| title_short | Novel delivery systems for phages and lysins in the topical management of wound infections: a narrative review |
| title_sort | novel delivery systems for phages and lysins in the topical management of wound infections a narrative review |
| topic | wound phage lysin multidrug-resistant therapy |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1526096/full |
| work_keys_str_mv | AT panyang noveldeliverysystemsforphagesandlysinsinthetopicalmanagementofwoundinfectionsanarrativereview AT jingli noveldeliverysystemsforphagesandlysinsinthetopicalmanagementofwoundinfectionsanarrativereview AT xiumeima noveldeliverysystemsforphagesandlysinsinthetopicalmanagementofwoundinfectionsanarrativereview AT nanhu noveldeliverysystemsforphagesandlysinsinthetopicalmanagementofwoundinfectionsanarrativereview AT zhangyongsong noveldeliverysystemsforphagesandlysinsinthetopicalmanagementofwoundinfectionsanarrativereview AT binchen noveldeliverysystemsforphagesandlysinsinthetopicalmanagementofwoundinfectionsanarrativereview AT shizhuli noveldeliverysystemsforphagesandlysinsinthetopicalmanagementofwoundinfectionsanarrativereview |