Correlation analysis between IL-1R/TLRs pathway and superficial dermatomycosis
Abstract Objective This study explored the correlation between interleukin-1 receptor/Toll-like receptor (IL-1R/TLRs)-mediated inflammatory signaling pathways and the severity of superficial dermatomycosis. Methods From May 2020 to August 2022, 76 patients with superficial dermatomycosis (infected g...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-03-01
|
| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-025-02434-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850057601915551744 |
|---|---|
| author | DongMei Tang XiaoXuan Cao BeiBei Yuan HongXing Zou MingDe Huang WeiFeng Shen |
| author_facet | DongMei Tang XiaoXuan Cao BeiBei Yuan HongXing Zou MingDe Huang WeiFeng Shen |
| author_sort | DongMei Tang |
| collection | DOAJ |
| description | Abstract Objective This study explored the correlation between interleukin-1 receptor/Toll-like receptor (IL-1R/TLRs)-mediated inflammatory signaling pathways and the severity of superficial dermatomycosis. Methods From May 2020 to August 2022, 76 patients with superficial dermatomycosis (infected group) and 52 patients without infection (non-infected group) were enrolled. The indicators related to IL-1R/TLRs pathway were analyzed, and the diagnostic value of the combined detection of each index for superficial dermatomycosis and disease severity was analyzed. The correlation between each index and the severity of infection was analyzed. Results IL-1β, TLR4, IL-6, and TNF-α in the infected group were higher than those in the non-infected group (P < 0.05). The AUC of IL-1R/TLRs combined detection in the group diagnosed with a superficial dermatomycosis was higher than that of each single detection (P < 0.05). IL-1β, TLR4, IL-6, and TNF-α in the severe group were higher than those in the mild group (P < 0.05). IL-1β, TLR4, IL-6, and TNF-α were positively correlated with the degree of infection (P < 0.05). The AUC of IL-1R/TLRs combined detection was higher than that of each single test (P < 0.05). IL-1β ≥ 2.87 ng/L, TLR4 ≥ 3.12 ng/L, IL-6 ≥ 4.58 ng/L, TNF-α ≥ 70.53 ng/L were the influencing factors of severe superficial dermatomycosis (P < 0.05). Conclusion IL-1R/TLRs pathway is related to the severity of superficial dermatomycosis, and the collective identification of each indicator provides diagnostic insight into infection severity. |
| format | Article |
| id | doaj-art-e1bcead985a446018932b20afa76deb1 |
| institution | DOAJ |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-e1bcead985a446018932b20afa76deb12025-08-20T02:51:23ZengBMCEuropean Journal of Medical Research2047-783X2025-03-013011810.1186/s40001-025-02434-5Correlation analysis between IL-1R/TLRs pathway and superficial dermatomycosisDongMei Tang0XiaoXuan Cao1BeiBei Yuan2HongXing Zou3MingDe Huang4WeiFeng Shen5Department of Laboratory Medicine, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing UniversityDepartment of Laboratory Medicine, Jiaxing Maternal and Child Health Care HospitalDepartment of Laboratory Medicine, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing UniversityDepartment of Laboratory Medicine, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing UniversityDepartment of Laboratory Medicine, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing UniversityDepartment of Laboratory Medicine, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing UniversityAbstract Objective This study explored the correlation between interleukin-1 receptor/Toll-like receptor (IL-1R/TLRs)-mediated inflammatory signaling pathways and the severity of superficial dermatomycosis. Methods From May 2020 to August 2022, 76 patients with superficial dermatomycosis (infected group) and 52 patients without infection (non-infected group) were enrolled. The indicators related to IL-1R/TLRs pathway were analyzed, and the diagnostic value of the combined detection of each index for superficial dermatomycosis and disease severity was analyzed. The correlation between each index and the severity of infection was analyzed. Results IL-1β, TLR4, IL-6, and TNF-α in the infected group were higher than those in the non-infected group (P < 0.05). The AUC of IL-1R/TLRs combined detection in the group diagnosed with a superficial dermatomycosis was higher than that of each single detection (P < 0.05). IL-1β, TLR4, IL-6, and TNF-α in the severe group were higher than those in the mild group (P < 0.05). IL-1β, TLR4, IL-6, and TNF-α were positively correlated with the degree of infection (P < 0.05). The AUC of IL-1R/TLRs combined detection was higher than that of each single test (P < 0.05). IL-1β ≥ 2.87 ng/L, TLR4 ≥ 3.12 ng/L, IL-6 ≥ 4.58 ng/L, TNF-α ≥ 70.53 ng/L were the influencing factors of severe superficial dermatomycosis (P < 0.05). Conclusion IL-1R/TLRs pathway is related to the severity of superficial dermatomycosis, and the collective identification of each indicator provides diagnostic insight into infection severity.https://doi.org/10.1186/s40001-025-02434-5Superficial dermatomycosisSeverityInterleukin-1βToll-like receptor 4Interleukin-6Tumor necrosis factor-alpha |
| spellingShingle | DongMei Tang XiaoXuan Cao BeiBei Yuan HongXing Zou MingDe Huang WeiFeng Shen Correlation analysis between IL-1R/TLRs pathway and superficial dermatomycosis European Journal of Medical Research Superficial dermatomycosis Severity Interleukin-1β Toll-like receptor 4 Interleukin-6 Tumor necrosis factor-alpha |
| title | Correlation analysis between IL-1R/TLRs pathway and superficial dermatomycosis |
| title_full | Correlation analysis between IL-1R/TLRs pathway and superficial dermatomycosis |
| title_fullStr | Correlation analysis between IL-1R/TLRs pathway and superficial dermatomycosis |
| title_full_unstemmed | Correlation analysis between IL-1R/TLRs pathway and superficial dermatomycosis |
| title_short | Correlation analysis between IL-1R/TLRs pathway and superficial dermatomycosis |
| title_sort | correlation analysis between il 1r tlrs pathway and superficial dermatomycosis |
| topic | Superficial dermatomycosis Severity Interleukin-1β Toll-like receptor 4 Interleukin-6 Tumor necrosis factor-alpha |
| url | https://doi.org/10.1186/s40001-025-02434-5 |
| work_keys_str_mv | AT dongmeitang correlationanalysisbetweenil1rtlrspathwayandsuperficialdermatomycosis AT xiaoxuancao correlationanalysisbetweenil1rtlrspathwayandsuperficialdermatomycosis AT beibeiyuan correlationanalysisbetweenil1rtlrspathwayandsuperficialdermatomycosis AT hongxingzou correlationanalysisbetweenil1rtlrspathwayandsuperficialdermatomycosis AT mingdehuang correlationanalysisbetweenil1rtlrspathwayandsuperficialdermatomycosis AT weifengshen correlationanalysisbetweenil1rtlrspathwayandsuperficialdermatomycosis |